摘要：The aim of this study was to investigate whether common variations in IL1B, IL1RN, IL1R1, and IL1R2 influence the risk of venous thrombosis。control study on the causes of deep venous thrombosis, t...

摘要：20Platelet PreparationPlatelets were purified from the blood of healthy donors using centrifugation and gel filtration as previously described。 21,22 Platelets were purified into PIPES/NaCl buffer...

摘要：Fluvastatin and colestimide equally lowered total and low density lipoprotein cholesterol levels in hypercholesterolemia。 Platelet aggregation was greater in hypercholesterolemia than in normochol...

摘要：Role of tissue factor in embryonic blood vessel development。 Role of the thrombin receptor in development and evidence for a second receptor。 Role of zymogen and activated factor X as scaffolds f...

摘要：Lipid molecules, even within a liquid phase, undergo diffusion much slower than water molecules。 Lipids in human breast adipose tissue, which consist mainly of triglyceride, are characterized by a...

摘要：Coagulation factor VIIa (VIIa) binding to its cellular receptor, tissue factor (TF), not only initiates the coagulation cascade but also induces cell signaling by activating G-protein coupled prote...

摘要：Spearman Rank Correlation Coefficients Between Serum Antibody Levels to Periodontal Pathogens, Endotoxin Concentration, and CVD Risk Factors in the Subcohort (n=320)Figure 2。 Joint Effects of Peri...

摘要：Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived ...

摘要：6 Fenofibrate, an agonist of the peroxisome proliferative activated receptor alpha protein (PPARA), has been shown to significantly reduce serum TG levels。 Demographic, Biochemical, and Genotypic ...

摘要：To explore potential interrelationships between lipoprotein-associated phosholipase A2 (Lp-PLA 2 ), the metabolic syndrome (MetS), and incident cardiovascular disease (CVD)。 Incidence of first CVD...

摘要：Repetition of IPC stimulus may be a simple, safe, and feasible therapeutic technique for endothelial protection of peripheral vessels。 Repetition of late IPC stimulus augments endothelium-dependen...

摘要：The enzyme acyl-coenzymeA (CoA):cholesterol O-acyl trans ferase 2 (ACAT2) in the liver synthesizes cholesteryl esters (CE) from cholesterol and fatty acyl-CoA, which get incorporated into apoB-cont...

摘要：Manumycin A treatment for 22 weeks decreased Ras activity, and reduced fatty streak lesion size at the aortic sinus to 43% of that in vehicle-treated apoE-deficient mice ( P 0。Farnesyltransferase ...

摘要：Plasmin activates macrophages via the annexin A2 heterotetramer composed of annexin A2 and S100A10 with subsequent stimulation of Janus kinase JAK1/TYK2 signaling。 Plasmin generated at sites of in...

摘要：【关键词】 atherosclerosis glutathione macrophage oxidized lowdensity lipoprotein oxidative stress IntroductionGlutathione reductase (GR) is a homodimeric flavoprotein that maintains the cellula...

摘要：Human and mouse PON3 and mouse apoAI proteins were detected using ECL plus。Lactonase, Paraoxonase, and LCAT ActivitiesLactonase ActivityPON3 lactonase activity was measured as previously described...

摘要：Grb2 is a ubiquitously expressed linker protein that couples growth factor receptor activation to downstream mitogen-activated protein kinase (MAPK) cascades。 Complete deletion of Grb2 in mice res...

摘要：Reticulon-4/Nogo (Nogo-B) protects mouse arteries from lumen loss by reducing smooth muscle cell (SMC) migration and intimal thickening。 Our goal was to determine plaque and circulating levels of ...

摘要：【关键词】 adipose tissue angiotensin II highdensity lipoprotein insulin IntroductionAdipose tissue has a central role in the energy metabolism adaptation to the nutritional environment because ...

摘要：Oxidized 1-palmitoyl-2-arachidonyl- sn -3-glycero-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)- sn -glycero-3-phosphocholine (PEIPC), which are...

摘要：Its stereo-isomer 6S-5,6,7,8-tetrahydro- L -biopterin (6S-BH4) and structurally similar pterin 6R,S-5,6,7,8-tetrahydro- D -neopterin (NH4) are also antioxidants but have no cofactor function。

摘要：Coronary angiography of ex vivo beating hearts 5 and 28 days after the treatment was performed using the third generation synchrotron radiation microangiography (SRM), which has potential to visual...

摘要：Acrolein, a known toxin in tobacco smoke, might be involved in atherogenesis。Acrolein (CH 2 =CH-CHO), a major product of organic combustion, including tobacco smoking, is the most reactive, &beta。...

摘要：【关键词】 sphingosinephosphate Rho ROCK PTEN permeability IntroductionVascular permeability is a tightly regulated process in various organ beds and an essential component of angiogenesis, tumo...

摘要：The cell cycle&ndash。associated transcription factor c-Myb increases Ca 2+ at the G 1 /S transition。 Here we show the mechanism through which c-Myb regulates expression of IP3R1。 A c-Myb neutral...

摘要：Expression of VEGF, VEGF Receptors, PDGF-B, TGF-&beta。 Receptor mechanisms and dose-response models for the effects of dioxins。 Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-t...

摘要：The purpose of this study was to determine the effect of cyclic strain on Notch signaling in endothelial cells。 Exposure of human endothelial cells (ECs) to cyclic strain (10%) resulted in tempora...

摘要：The glutathione (GSH)/glutaredoxin (Grx) system regulates activities of many redox sensitive enzymes。induced apoptosis by regulating the redox state of Akt。 Grx can be regulated by redox state。 ...

摘要：Mouse hearts were subjected to 30 minutes of global ischemia followed by 90 minutes of reperfusion and their vasoactivity before and after I/R was examined in wild-type (WT), tumor necrosis factor ...

摘要：Materials and MethodsExpression of HO-1 and PPAR isotypes was studied using real-time polymerase chain reaction or Western blotting。ResultsLigands for PPAR and PPAR Induce HO-1 Expression in Human...

摘要：Adventitial angiogenesis, immunoinflammation, and fibrosis sequentially interact and their net balance defines the participation of the adventitial response in arterial pathology。 Adventitial spro...

摘要：Vascular Smooth Muscle Heterogeneity: A Lineage PerspectiveMost of what we have traditionally called SMC heterogeneity comes from studies of cytoskeletal and contractile protein expression in vascu...

摘要：Because of its key position in the coagulation cascade and its limited roles outside of coagulation, Factor Xa has emerged as an attractive target for novel anticoagulants。 As a result, the past d...

摘要：Plasminogen activation system。 Plasminogen binds to lysine residues within fibrin via lysine-binding sites contained in plasminogen。 16Role of PA System in Controlling Intimal Hyperplasia After V...