摘要：Platelets play a dual role in thrombosis by forming aggregates and stimulating coagulation。orgResultsMicrodomains of Aggregated and Procoagulant Platelets in Thrombi Formed Under Shear StressIn th...

摘要：Platelets are activated by native LDL (nLDL) through apoE Receptor 2‘ (apoER2‘)-mediated signaling to p38 MAPK and by oxidized LDL (oxLDL) through lysophosphatidic acid (LPA) signaling to Rho A a...

摘要：We tested the hypothesis that the phosphatidylinositol-3 kinase (PI3K)/Akt pathway mediates the neuroprotective effect of combination therapy of atorvastatin and tissue-type plasminogen activator (...

摘要：【摘要】 Objective&mdash。 To determine the prognostic utility of lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) for specific adverse cardiovascular outcomes in patients with stable coro...

摘要：8 Nateglinide is a D-phenylalanine derivative and an insulinotropic agent with a rapid onset and short duration of action。Assessment of IMT of the Common Carotid ArteryUltrasonography of the carot...

摘要：Genomic changes were defined in cultures of regenerated porcine coronary endothelial cells to explain the alterations that underlie their dysfunction。Genomic changes were determined in cultured re...

摘要：The genetic determinants of severe hypertriglyceridemia (HTG。 MIM 144650 ) in adults are poorly defined。 We therefore resequenced 3 candidate genes, namely LPL, APOC2, and APOA5, to search for ac...

摘要：We postulated that low concentrations of oxLDL might induce low levels of ROS and initiate angiogenesis。 oxLDL (0。 oxLDL-mediated VEGF expression and tube formation were suppressed by a specific ...

摘要：Pioglitazone, an antihyperglycemic drug, increases plasma high-density lipoprotein (HDL)-cholesterol in patients with type 2 diabetes。 The mechanisms by which pioglitazone regulate HDL levels are ...

摘要：Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4。 In 24-hour fasted mice, Angptl4 overexpr...

摘要：Increased Lipid and Protein Oxidation in SR-BI Knockout MiceNext, we investigated the effect of SR-BI deficiency on lipid and protein oxidation by measuring 2 distinct and specific markers, isopros...

摘要：Cholesterol parameters in macrophages of PLTP-deficient mice were normalized by dietary -tocopherol supplementation。 Cholesterol parameters in the macrophages of PLTP-deficient mice were normalize...

摘要：Esculeogenin A significantly inhibited the accumulation of cholesterol ester (CE) induced by acetylated low density lipoprotein (acetyl-LDL) in human monocyte-derived macrophages (HMDM) in a dose-d...

摘要：The sphingolipid analogue drug FTY720 mediates retrafficking of immune cells and inhibits their homing to inflammatory sites。 We have evaluated the effect of FTY720 on atherogenesis and lipid meta...

摘要：Local cotransfection of TLR2 and TLR4 at the vessel wall synergistically accelerated atherosclerosis in carotid arteries of rabbits fed a high-cholesterol diet。Local Expression of TLR2 and TLR4 Sy...

摘要：High mobility group box 1 protein (HMGB1) is a cytokine released by necrotic and inflammatory cells in response to injury。 2High Mobility group box 1 protein (HMGB1) is a multifunctional ubiquitou...

摘要：Angiotensin II (Ang-II) and mononuclear leukocytes are involved in atherosclerosis。 This study reports the inhibition of Ang-II&ndash。induced mononuclear cell recruitment by CXCR2 antagonism and ...

摘要：Angiotensin II (ATII) type 1 receptor (AT1R) blocker (ARB) has been shown to inhibit neointimal formation。 Bone marrow&ndash。derived mononuclear cells (BM-MNCs) give rise to smooth muscle (SM)-li...

摘要：Angiotensin II (Ang II) induces the phenotypic modulation and hypertrophy of vascular smooth muscle cells (VSMCs), which is implicated in the pathogenesis of hypertension, atherosclerosis, and diab...

摘要：Demography of Patients Underwent Brachial Artery Ultrasound InvestigationIsolation of Human Coronary Arterioles and Experimental ProtocolsWith the use of microsurgical instruments and an operating ...

摘要：4-Hydroxy-2-nonenal (4-HNE) is an abundant electrophilic lipid that mediates oxidative stress in endothelium by mechanisms that remain controversial。4-Hydroxy-2-nonenal (4-HNE) mediates oxidative ...

摘要：Rho kinase mediates vascular leakage caused by many vasoactive agents including thrombin。 Enhanced Rho kinase activity induces endothelial barrier dysfunction by a contractile mechanism via inacti...

摘要：Nuclear Trx plays an important role in endothelial cell apoptosis。 Nuclear import of Trx is required for the antiapoptotic properties of H 2 O 2。 Nuclear Trx binds to several transcription factor...

摘要：Redox signaling mediated by Nox2-containing NADPH oxidase has been implicated in angiogenic responses both in vitro and in vivo。 Because Nox4 type NADPH oxidase is also highly expressed in endothe...

摘要：1, CD3, and CD4, invaded the collateral vessel wall。 Arteriogenesis was impaired in C57BL/6 mice depleted for Natural Killer (NK)-cells by anti-NK1。1 + Natural Killer T (NKT)-cells, indicating th...