摘要：1 Division of Infectious Diseases, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021 2 Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Ca...

摘要：Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex。 In this co...

摘要：The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia Immunization with a T cell–dependent antigen elicits production of specific memory B cells and antibody-secreting...

摘要：1 Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 2 Department of Pathology and Laborator...

摘要：Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid 28049, Spain Exit from the endoplasmic reticulum (ER) is an imp...

摘要：277, Institut Pasteur, 75724 Paris, Cedex 15, France The lineage relationships of central–memory T cells (TCM) cells and effector–memory T cells (TEM), as well as their homeostasis and recall cap...

摘要：To investigate the mechanisms underlying this striking association, we examined autoantigen expression in normal muscle and in muscle from patients with autoimmune myositis。 Although myositis auto...

摘要：1 Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637 2 Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute 3 Department of Pediatric Oncolo...

摘要：1 Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women‘s Hospital, Boston, MA 02115 2 Harvard Medical School, Boston, MA 02115 To mount an effective type 1 ...

摘要：We recently demonstrated that pollen not only function as allergen carriers but also as rich sources of bioactive lipids that attract cells involved in allergic inflammation such as neutrophils and...

摘要：1 Radiation Oncology Research Laboratory, Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201 2 Section on DNA Replication, Repair and Mutagenesis, Laboratory of Genomic I...

摘要：1 Neuroimmunology Unit, European Neuroscience Institute Gttingen 2 Institute of Multiple Sclerosis Research, University of Gttingen and Hertie-Foundation, 37073 Gttingen, Germany Elimination of apo...

摘要：Here we comment on how, when, and why biochemistry is likely to emerge from the shadows and into the spotlight to elucidate how the somatic mutation of antibody variable (V) regions is generated。 ...

摘要：Humoral immunity appears to be based on immunological memory provided by memory plasma cells, which secrete protective antibodies, and memory B cells, which react to antigen challenge by differenti...

摘要：Immunological phenomena that were once deduced from genetic, biochemical, and in situ approaches are now being witnessed in living color, in three dimensions, and in real time。 At the population, ...

摘要：During a recent roundtable discussion, we captured some personal perspectives on the new insight that advanced imaging techniques promise to bring to the study of lymphocyte signaling。 The experts...

摘要：, B-6041 Gosselies, Belgium 6 Centro IDET, Institute of General Pathology, University of Milan, 20133 Milan, Italy Chemerin is a chemotactic agent that was recently identified as the ligand of Chem...

摘要：1 Department of Research, Laboratory of Transplantation Immunology and Nephrology, University Hospital-Basel, CH-4031 Basel, Switzerland 2 Inmunología, Facultad de Medicina, Universidad Complutens...

摘要：Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655 CD8 T cell cross-reactivity between viruses can play roles in protective heterologous immunity and damaging ...