摘要:1 Peter Medawar Building, University of Oxford, Oxford OX13SY, UK 2 Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA 02129 3 HPP, The Doris Duke Medical Research Insti...
07-05-12摘要:New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development。 By connecting homotypic SLAM family receptor interactions with the FynT S...
07-05-12摘要:1 Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, A-1090 Vienna, Austria 2 Institute of Pharmacology and Toxicology, University of Vienna, A-1090 Vienna...
07-05-12摘要:Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)- in plasmacytoid dendritic cells (pDCs)。 This induction requires the formation of a complex consisting of the adaptor MyD88, ...
07-05-12摘要:Here, we studied the potential of platelet-derived growth factor (PDGF) receptor tyrosine kinase inhibitors (RTKIs) to attenuate radiation-induced pulmonary fibrosis。 Our findings suggest a pivota...
07-05-12摘要:To investigate the underlying mechanisms of this increased susceptibility, we examined virus replication and innate responses to rhinovirus (RV)-16 infection of primary bronchial epithelial cells f...
07-05-12摘要:, Shizuoka 411-8731, Japan 5 Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa 6 Sir William Dunn School of Pathology, University of Oxfo...
07-05-12摘要:1 Department of Biochemistry, McGill Cancer Center 2 Center for the Study of Host Resistance, Department of Human Genetics, McGill University, Montreal, Quebec H3G 1Y6, Canada 3 Biotechnology Resea...
07-05-12摘要:however, the mechanisms regulating adult bone mass are poorly understood。 Cas-interacting zinc finger protein (CIZ) is a nucleocytoplasmic shuttling protein that localizes at cell adhesion plaques...
07-05-12摘要:Unité du Développement des Lymphocytes, Institute National de la Santé et de la Recherche Medicale U668, Institut Pasteur, 75724 Paris, France Interleukin-7 (IL-7) promotes survival and expansio...
07-05-12摘要:1 Department of Pulmonary Medicine, Erasmus MC, 3015 GE Rotterdam, Netherlands 2 Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel 3 Institut National de la Santé et d...
07-05-12摘要:1 Cytos Biotechnology, Swiss Federal Institute of Technology, Zurich-Schlieren 8952, Switzerland 2 Molecular Biomedicine, Swiss Federal Institute of Technology, Zurich-Schlieren 8952, Switzerland H...
07-05-12摘要:Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses。 Here, we define the function of the vaccinia virus (VV) protein A46R and show it inh...
07-05-12摘要:Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued。 Infection, immunity, and aging...
07-05-12摘要:Bone remodeling, a coupled process involving bone resorption and formation, is initiated by mechanical signals and is controlled by local and systemic factors that regulate osteoblast and osteoclas...
07-05-12摘要:Trudeau Institute, Saranac Lake, NY 12983 Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells from aged mice retain a naive phenotype, but exhibit reduced p...
07-05-12摘要:Wells Center, Indiana University School of Medicine, Indianapolis, IN 46202 Granulocyte/macrophage colony-stimulating factor (GM-CSF) promotes the survival, proliferation, and differentiation of my...
07-05-12摘要:1 Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan 2 Department of Laboratory Animal Science, Tokyo Metropolitan Institute of Medical Science, Toky...
07-05-12摘要:As assessed by flow cytometry and immunoblotting, C3 deposition increased on the platelet surface upon cell activation with different agonists。 In summary, we have found that platelets are capable...
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