摘要：Lessons from mouse models: nuggets Typical mouse models of allergen-mediated pulmonary inflammation involve intraperitoneal immunization with chicken egg ovalbumin (OVA) precipitated with aluminum ...

摘要：Although it is known that BH3-only proteins and the multi-BH domain proteins, Bak and Bax, are essential for programmed cell death, the overlapping role of these two subgroups has not been examined...

摘要：1 Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, England, UK 2 Institute of Medical Immunology, Charité, 10117 Berlin, Germany The significance of c...

摘要：1 Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, England, UK 2 Department of Veterinary Clinical Studies, U...

摘要：1 Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia 2 The Walter and Eliza Hall Institute for Medical Research, Parkvill...

摘要：1 Department of Surgery, Immunology, and Hygiene, Technische Universitt München, 81675 Munich, Germany 2 Institute of Medical Microbiology, Immunology, and Hygiene, Technische Universitt München,...

摘要：1 Laboratoire d‘Immunologie Cellulaire et Tissulaire, INSERM U543 2 Service d‘Ophtalmologie, EA 2387 3 Laboratoire de Virologie, EA 2387 4 Unité d‘Epidémiologie Clinique et Traitements de l‘I...

摘要：Both processes are triggered by activation-induced cytidine deaminase (AID) and require UNG-encoded uracil-DNA glycosylase。 Here, we demonstrate that extracts of UNG-proficient human B cell lines ...

摘要：1 Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2 BSL-3 Core Virology Laboratory, Vaccine ...

摘要：Most of our understanding of the immune mechanisms underlying asthma comes from studies in man and mouse。 We advocate more extensive use of nonhuman primate asthma models to reconcile these differ...

摘要：Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack。 La...

摘要：1 Genetics Program, Tufts University School of Medicine, Boston, MA 02111 2 Department of Pathology, Tufts University School of Medicine, Boston, MA 02111 3 Program in Immunology and Virology, Univ...

摘要：1 Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 2 Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka ...

摘要：Paradoxically, IL-4 instructs dendritic cells (DCs) to promote Th1 cell differentiation。 We investigated the mechanisms by which IL-4 directs CD4 T cells toward the Th1 cell lineage。 Our study de...

摘要：The Trudeau Institute, Saranac Lake, NY 12983 Mice immunized against Mycobacterium tuberculosis (Mtb) infection by curing them of a primary lung infection were compared with naive mice in terms of ...

摘要：meningitidis that are capable of breaking the normal commensal relationship with humans and causing invasive disease。 The importance of bacterial factors—suggested by early epidemiological studie...