摘要：Hooper Foundation and the Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California San Francisco, CA 94143 6 Department of Cancer Biology, Wake Forest Univer...

摘要：1 Department of Etiology and Carcinogenesis, Cancer Institute and Hospital 2 Department of Gynecologic Oncology, Cancer Institute and Hospital 3 Department of Medical Oncology, Cancer Institute and...

摘要：it is well established that CFTR plays a pivotal role in cholera toxin (CTX)-induced secretory diarrhea。 Lysophosphatidic acid (LPA), a naturally occurring phospholipid present in blood and foods,...

摘要：A single administration of agonistic anti-GITR monoclonal antibody (mAb) to tumor-bearing mice intravenously or directly into tumors provoked potent tumor-specific immunity and eradicated establish...

摘要：tb) survives in macrophages in part by limiting phagosome–lysosome (P-L) fusion。tb mannose-capped lipoarabinomannan (ManLAM) blocks phagosome maturation。 The pattern recognition mannose receptor...

摘要：Mice lacking expression of either of these molecules because of targeted deletion lack development of T cells after the double negative (DN) 3 stage (4, 5)。 In addition, although targeted deletion...

摘要：1 Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892 2 Howard Hughes Medical Institute, NIH Research Scholars Program, Bethesda, MD...

摘要：1 Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 2 Center for Infectious Medicine, Department of Medicine, K...

摘要：We demonstrate that Gr-1+CD11b+ cells generated by transplantation and their IFN- production triggered by V14 NKT cells are an essential component and a major cause of early graft loss of pancreati...

摘要：1 Institut National de la Santé et de la Recherche Médicale, U517, University of Burgundy, 21079 Dijon, France 2 ERM 0208, Institut National de la Santé et de la Recherche Médicale 3 UMR 8125, ...

摘要：1 Department of Surgery, University of Pittsburgh 2 Department of Cell Biology and Physiology, University of Pittsburgh 3 Department of Radiation Oncology, University of Pittsburgh 4 Department of ...

摘要：Scott Cancer Center 2 Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA 70112 3 Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, David G...

摘要：It has been proposed that thymic output of regulatory T (T reg) cells is delayed during ontogeny and that the development of autoimmune disease in neonatally thymectomized mice is caused by the esc...