摘要：These results demonstrate a fundamental bimodal role for the Y1 receptor in the immune system, serving as a strong negative regulator on T cells as well as a key activator of APC function。 NPY, ne...

摘要：Recent studies suggest that human regulatory T (T reg) cells protect against the development of allergic and asthmatic disease and that their function is impaired during active disease。 Two new st...

摘要：1 Leukocyte Biology Section, Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, SW7 2AZ London, England, UK 2 Discovery BioScience, AstraZene...

摘要：1 Division of Immunobiology, Cincinnati Children‘s Hospital Medical Center, Cincinnati, OH 45229 2 Division of Molecular Immunology, Cincinnati Children‘s Hospital Medical Center, Cincinnati, OH ...

摘要：1 Dynavax Technologies, Berkeley, CA 94710 2 Division of Immunobiology, Cincinnati Children‘s Hospital Medical Center, Cincinnati, OH 45229 A single treatment with a CpG-containing immunostimulato...

摘要：, Wellesley, MA 02481 Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies to certain cellular macromolecules, such as the small nuclear rib...

摘要：Michael‘s Hospital, Toronto, Ontario M5B 1W8, Canada MEG2, a protein tyrosine phosphatase with a unique NH2-terminal lipid-binding domain, binds to and is modulated by the polyphosphoinositides PI...

摘要：1 Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305 2 Department of Pathology, Stanford University School of Medicine, Stanford, ...

摘要：The fact that these snRNAs are U rich makes them appropriate targets to test for immune stimulation through TLR7/8。 Sm/RNP is a particularly appropriate model antigen, as the highly conserved doma...

摘要：1 Department of Microbiology, Columbia University College of Physicians and Surgeons 2 Department of Biological Sciences, Columbia University, New York, NY 10032 Long-lived plasma cells, residing p...

摘要：1 Integrated Department of Immunology, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80262 2 Department of Medicine, National Jewish ...

摘要：, Chiyoda-ku, Tokyo 100-0011, Japan To detect as yet unidentified cell-surface molecules specific to hematopoietic stem cells (HSCs), a modified signal sequence trap was successfully applied to mou...

摘要：Examination of expressional levels of the equilibrative nucleoside transporter (ENT)1 and ENT2 revealed a transcriptionally dependent decrease in mRNA, protein, and function in endothelia and epith...

摘要：We asked if immunity could be achieved by delivering irradiated, major histocompatibility complex–negative plasmacytoma cells to maturing mouse dendritic cells (DCs) within lymphoid organs。 The n...

摘要：1 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037 2 Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 3 Skaggs Institute for Chemical B...