摘要：1 Laboratory of Immunology, National Eye Institute, National Institutes of Health (NIH), Bethesda, MD 20892 2 Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912 Susceptibili...

摘要：Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021 CD4+ T cells are classically thought to orchestrate adaptive immune responses。 But recent studies d...

摘要：Recent findings indicate a novel role for polyisoprenyl phosphates (PIPPs) as natural down-regulatory signals in neutrophils。 Here, we establish presqualene diphosphate (PSDP) as an endogenous PIP...

摘要：1 Gladstone Institute of Virology and Immunology, 2 Department of Microbiology and Immunology, 3 Department of Medicine, University of California, San Francisco, San Francisco, CA 94158 Human imm...

摘要：1 Department of Surgery, University of Michigan, Ann Arbor, MI 48109 2 Tulane University Health Sciences Center, New Orleans, LA 70112 3 Louisianna State University Health Sciences Center, New Orle...

摘要：1 Department of Pathology and Transplantation Research Center, Brigham and Women‘s Hospital and Children‘s Hospital Boston, 2 Department of Medical Oncology, Dana Farber Cancer Institute, Harvar...

摘要：1 Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK 2 Division of Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK ...

摘要：Berne Cardiovascular Research Center, 3 Department of Biomedical Engineering, 4 Internal Medicine, Microbiology Molecular Physiology and Biological Physics, University of Virginia Health Sciences ...

摘要：Interdisciplinary Graduate Program in Immunology Department of Microbiology, University of Iowa, Iowa City, IA 52242 The formation of memory CD8 T cells is an important goal of vaccination。 Howeve...

摘要：Louis, MO 63110 Mice deficient in lymphocytes are more resistant than normal mice to Listeria monocytogenes infection during the early innate immune response。 This paradox remains unresolved: lymp...

摘要：1 Department of Medicine, 2 Department of Pediatrics, 3 Department of Cancer Biology, 4 Department of Cell and Developmental Biology and Pharmacology, 5 Vanderbilt-Ingram Cancer Center, Vanderbil...

摘要：1 Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK 2 The Dermatology Centre, University of Manchester, Salford, Manchester, M6 8HD, England, UK We have examined...

摘要：In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells。 The newest Th cell subset produces the cytokine IL-17。 We will also disc...

摘要：1 Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2 University of California, Berkeley, and Public Health Research Institut...

摘要：1 Department for Medical Microbiology and Hygiene, University Clinic of Freiburg, 79104 Freiburg, Germany 2 Swedish Institute for Infectious Diseases Control, 17177 Stockholm, Sweden The role of in...

摘要：We have reported previously that extracellular adherence protein (Eap) of Staphylococcus aureus exerts antiinflammatory activities by interacting with ICAM-1 and blocking 2-integrin–dependent neut...

摘要：1 Clinical Cooperation Group, Institute for Clinical and Molecular Biology, GSF-National Research Center for Environment and Health 2 Children‘s Hospital, Hematology-Oncology, Technical Universit...

摘要：1 Medical Scientist Program, Integrated Biomedical Science Graduate Program, 2 Department of Molecular Virology, Immunology, and Medical Genetics, 3 Department of Epidemiology and Biometrics, 4 Di...

摘要：1 Experimental Pathology, Immunology, and Experimental Medical Science, Lund University, Lund 22185, Sweden 2 Vrije Universiteit, Molecular Cell Biology, 1081 BT Amsterdam, Netherlands 3 Immunobiol...

摘要：Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455 We explored the relationship between the time of naive CD4+ T cell exposure to antig...

摘要：1 Department of Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920-0934, Japan 2 PRESTO, Japan Science Technology Agency, Saitama 332-0012, Japan Endothelial cells (ECs...

摘要：1 Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA, 30912 2 Savannah River National Laboratory, Aiken, SC 29808 3 Department of Medi...

摘要：1 Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW 2042, Australia 2 Faculty of Medicine, University of Sydney, Camperdown NSW 2006, Australia B cells responding to T-dependent ...

摘要：Oxidation of low-density lipoprotein (LDL) is thought to contribute to atherosclerosis and cardiovascular disease。 Consistent with this idea, the antioxidant drug probucol reduces the risk of rest...

摘要：1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 2 Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Oht...

摘要：We demonstrate that il25–/– mice display inefficient Nippostrongylus brasiliensis expulsion and delayed cytokine production by T helper 2 cells。 We further establish a key role for interleukin (...

摘要：1 Centre for Vascular Research, School of Medical Sciences, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney NSW 2052, Australia 2 Eastern Heart Clinic...

摘要：Transgenic mouse studies indicate that high levels of SOCS3 in T cells result in type 2 T helper cell (Th2) skewing and lead to hypersensitivity to allergic diseases。 To define the physiological r...

摘要：Costimulation regulates the activation of naive T cells as they first encounter antigens in the secondary lymphoid organs。 New evidence shows that negative costimulators expressed by tumors and no...

摘要：Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada The promyelocytic leukemia–retinoic acid receptor (PML-RAR) protein of acute promyelocytic leukemia (APL) is onco...

摘要：Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 Neutrophil recruitment i...

摘要：Using genetic and pharmacologic approaches in the K/BxN serum transfer model of arthritis, we find that autoantibody-driven erosive synovitis is critically reliant on the generation of leukotrienes...

摘要：1 Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 2 Discovery Research, Schering-Plough Biopharma, Palo Alto, CA 94304 3 Division of Veterinary Clinical Studies, Univ...