摘要：However, the mechanism of peptide selection is incompletely understood, and, consequently, the differences in the immunogenicity of protein antigens remain largely unpredictable and difficult to ma...

摘要：1 Division of Immunopathology, Institute of Pathology, University of Bern, 3010 Bern, Switzerland 2 Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche S...

摘要：Here we present evidence for lysosome-mediated degradation of Toxoplasma gondii after invasion of macrophages activated in vivo。 Pathogen elimination was dependent on the interferon inducible-p47 ...

摘要：1 Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada 2 Department of Immunology and 3 Department of Laboratory Medicine and Pathobiology, University of ...

摘要：Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK Immunoglobulin (Ig) class switching is initiated by deamination of CU within the immunoglobulin heavy chain locus, ca...

摘要：1 Board of Governors‘ Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048 2 Department of Medicine, and Department of Molecular and Medical Pharmacology, David...

摘要：1 Department of Surgery Transplant Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 2 Department of Medicine, Johns Hopkins University School of Medicine, Balt...

摘要：Louis, MO 63110 Activation of naive T cells requires the integration of signals through the antigen receptor and CD28。 Although there is agreement on the importance of CD28, there remains controve...

摘要：Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 CD8+ T cells only require a brief stimulation with antigen in vitro to divide and different...

摘要：In this study, we show that during LCMV infection, CD27 signaling on CD4+ T cells enhances the secretion of interferon- and tumor necrosis factor-。 Consequently, infection with the otherwise persi...

摘要：, Rockville, MD 20850 4 The Rockefeller University, New York, NY 10021 The inappropriate expansion and activation of autoreactive memory B cells and plasmablasts contributes to loss of self-toleran...

摘要：1 Autoimmunity and Inflammation Program, Hospital for Special Surgery, Weill Medical College, Cornell University, New York, NY 10021 2 Department of Medicine and Department of Immunology, Universit...

摘要：1 Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021 2 Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10021 Sympathetic n...

摘要：1 Howard Hughes Medical Institute 2 Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111 Legionella pneumophila, the causative agent of Legionnair...

摘要：, Mountain View, CA 94043 2 Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016 3 Division of Hematology, Stanford University School of Medicine, Sta...