摘要:Restriction Fragment Analysis of Mutations A restriction endonuclease site was engineered about each of the two nonsense mutation by the use of custom PCR primers, which were designed with the prog...
07-05-14摘要:Section on Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London Pfizer Global Research and Development, Kent, United Kingdom ABSTRACT Rationale: Phosphodieste...
07-05-14摘要:Continuous positive airway pressure (CPAP) is recognized to be an effective treatment for sleep apnea (16)。 Lung volume was manipulated with the subject lying supine in a head-out rigid shell (Por...
07-05-14摘要:Department of Cardiology and Pneumology, Georg-August-Universitt, Gttingen, Germany ABSTRACT Rationale: Atrial overdrive pacing markedly improved sleep-disordered breathing in a recent study。 Over...
07-05-14摘要:Programme PAC-CI Centre de Diagnostic et de Recherches sur le SIDA (CeDReS), Centre Hospitalier Universitaire de Treichville, Abidjan, Cte d‘Ivoire INSERM U。593, Universitee Victor Segalen Bordea...
07-05-14摘要:Lead Programme for TB Research, Medical Research Council Department of Pediatrics and Child Health, Tygerberg Lead Programme for TB Research, Medical Research Council, Pretoria King George V Hospit...
07-05-14摘要:Harvard Medical School and Children‘s Hospital, Boston, Massachusetts Department of Pathology, Center for Lung Research, Nashville, Tennessee Pulmonary and Critical Care Medicine, University of Fl...
07-05-14摘要:National Jewish Medical and Research Center, Denver, Colorado ABSTRACT Severe asthma remains poorly understood and frustrating to care for, partly because it is a heterogeneous disease。 Patients w...
07-05-14摘要:Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado Department of Microbiology and Immunology, James Graham Brown Cancer Center, Univer...
07-05-14摘要:Exposure to cigarette smoke results in more frequent asthma attacks, more asthma symptoms (1), a lower lung function (2), an accelerated decline in lung function (2, 3), and higher asthma severity ...
07-05-14摘要:Among the candidate genes in this region is CD14。 Methods: To determine whether polymorphisms in the CD14 gene are related to this gene-by-environment interaction in Latinos, we used both family-b...
07-05-14摘要:Joseph‘s Healthcare Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Medicine, University of Otago, Dunedin, New Zealand ABSTRACT Rationale: Factors predicting ...
07-05-14摘要:Departments of Medical Genetics, Pediatrics Immunology, Graduate School of Comprehensive Human Sciences, University of Tsukuba Department of Pediatrics, Tsukuba College of Technology Tsukuba Medica...
07-05-14摘要:Service de Pneumologie, Hpital de Hautepierre, Strasbourg, France ABSTRACT Rationale: Severe pulmonary hypertension occurs occasionally in patients with chronic obstructive pulmonary disease (COPD)...
07-05-14摘要:Divisions of Infectious Diseases and Pulmonary and Critical Care Medicine, Department of Medicine Departments of Microbiology, Physiology and Biophysics, Social and Preventive Medicine Biostatistic...
07-05-14摘要:Results: Diaphragm muscle fibers from patients with COPD showed reduced force generation per cross-sectional area, and reduced myosin heavy chain content per half sarcomere。 Key Words: contractili...
07-05-14摘要:Oxygenation failure was serially assessed by calculating the alveolareCarterial oxygen gradient (A-aDO2) (19), the PaO2/FiO2 ratio , and the oxygenation index 。
07-05-14摘要:Failure of this supplementation to maintain serum 25-OHD levels above 30 ng/ml should lead to aggressive repletion with high-dose oral ergocalciferol。 Failure of this regimen to raise serum 25-OHD...
07-05-14摘要:Surfactant phosphatidylcholine (PC) molecular species composition during alveolarization has not been examined。 Besides Surfactant proteins B and C (35), unsaturated PC, such as 16:0/18:1PC, has a...
07-05-14摘要:Neurotrophin Assays NGF concentration was measured in serum, BAL supernatants, and BAL cell pellets using a modification of the highly sensitive and specific enzyme-linked immunoassay originally de...
07-05-14摘要:Breathing disorders show considerable interindividual variability, ranging in severity from relatively mild hypoventilation during quiet sleep, with adequate ventilation during wakefulness, to comp...
07-05-14摘要:Objectives: Within the context of a prospective birth cohort study, we investigated the association between single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) g...
07-05-14摘要:Department of Physiology, University of Duisburg-Essen, Essen Department of Physiology, Ruhr University, Bochum, Germany ABSTRACT Rationale: In vivo inhibition of the sodium/proton exchanger 3 (NHE...
07-05-14摘要:Departments of Medicine and Microbiology, University of Texas Health Center, Tyler, Texas Louisiana State University Health Science Center, Shreveport, Louisiana ABSTRACT Ethambutol (EMB) is an imp...
07-05-14摘要:Similar findings were reported from cross-sectional analyses in the European Community Respiratory Health Survey, where the prevalence of asthma and wheeze were higher in adults who reported exposu...
07-05-14摘要:We therefore evaluated the integrin-3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes。 Meth...
07-05-14摘要:Respiratory Pharmacology Group, Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom ABSTRACT Rationale: Emphysema is one component of chronic obstructiv...
07-05-14摘要:Departments of Internal Medicine and Pediatrics, University of Iowa Carver College of Medicine Veterans Affairs Medical Center, Iowa City, Iowa Department of Medicine, University at Buffalo, State ...
07-05-14摘要:Ventilator-induced lung injury (VILI) has been studied in different animal models with high VT ventilation (2eC4)。 Hyaluronan (HA) is a common component of extracellular matrix。 Ventilator-induce...
07-05-14摘要:Sleep Unit, Department of Respiratory Medicine, Royal Prince Alfred Hospital Sleep Research Group, Woolcock Institute for Medical Research, University of Sydney, Sydney, Australia ABSTRACT Rational...
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