摘要：Division of Sleep Medicine, Harvard Medical School and Brigham and Women‘s Hospital, Boston, Massachusetts ABSTRACT Considerable progress has been made over the last several decades in our underst...

摘要：Results: Endotoxin concentration (EU/mg) and load (EU/m2) were highly correlated (r = 0。 Key Words: airway inflammation house dust lipopolysaccharide wheeze Endotoxins are inflammatory lipopolysac...

摘要：Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan ABSTRACT Rationale: Matrix metalloproteinase 9 (MMP-9) has proteolytic activity against connective ti...

摘要：Division of Pulmonary and Critical Care Medicine and Lung Biology Center, Departments of Medicine and Epidemiology and Biostatistics Cardiovascular Research Institute, University of California, San...

摘要：Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study。 Resuscitation with room air instead of 100% oxygen prevents oxidative s...

摘要：Department of Environmental Health, Center for Environmental Genetics, and Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati Medical Center...

摘要：Cystic fibrosis (CF), caused by mutations in the CF transmembrane regulator (CFTR) gene (10), is the most common fatal inherited disease in whites, with a frequency of 1 in 1,461 live births in Ire...

摘要：Sputum was arrayed by two-dimensional electrophoresis and differentially expressed proteins were identified by proteomic analysis。 Measurements and Main Results: Sputum profiles from adults with C...

摘要：Laboratoire Reponses Cellulaires et Fonctionnelles a l‘Hypoxie, Universite Paris 13, Bobigny Service de Physiologie et Explorations Fonctionnelles, and Service de Pharmacie, Hpital Avicenne, AP-HP...

摘要：Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People‘s Republic of China ABSTRACT Background: Active suppression by CD4+CD25+ regulato...

摘要：Systemic administration of tumor necrosis factor (TNF) in rats before inoculation of bacteria into the lungs worsens pneumonia by reducing alveolar neutrophil recruitment and bacterial clearance (1...

摘要：Sleep Research Laboratory of the Toronto Rehabilitation Institute, Center for Sleep Medicine and Circadian Biology, University of Toronto, Toronto, Ontario, Canada Departments of Population Health ...

摘要：Objectives and Methods: By using a previously validated murine model that involves immunizing mice with Mycobacterium bovis bacillus Calmette-Guerin to augment host immunity before infection with v...

摘要：Rifapentine (RPT), a long-lasting rifamycin, is currently recommended for use at a dose of 10 mg/kg in combination with isoniazid (INH) during once-weekly continuation phase therapy (4)。 Moreover,...

摘要：Ghent University Hospital, Ghent, Belgium FOOTNOTES Conflict of Interest Statement: P。D。 does not have a financial relationship with a commercial entity that has an interest in the subject of thi...

摘要：Research Center for Molecular Diagnostics and Therapy, Moscow, Russian Federation National Jewish Medical and Research Center, Denver, Colorado ABSTRACT Nanoparticle-based drug delivery systems hav...

摘要：National Heart and Lung Institute, Imperial College London。 Lung and extrathoracic radioaerosol deposition were quantified using planar -scintigraphy。 Conclusions: Regional targeting of inhaled 2...

摘要：RESULTS Identification of Polymorphisms We started our investigation by genotyping those three amino acid variants that were already listed in public single nucleotide polymorphism (SNP) databases ...

摘要：The change in lung mechanics during exacerbation and its relationship to symptoms in spontaneously breathing individuals has not been described。 Objective: We hypothesized that changes in both air...

摘要：Inclusion criteria were as follows: (1) moderate to severe COPD according to the Global Initiative for Chronic Obstructive Lung Disease guidelines (11), (2) age older than 50 yr, (3) smoking histor...

摘要：Arginases compete for L-arginine, the substrate of nitric oxide synthesis。 Key Words: inflammatory marker nitric oxide pulmonary function Arginases catalyze the hydrolysis of L-arginine to form L-...

摘要：Fatty Acids in Erythrocyte Membranes Blood samples were immediately centrifuged and frozen in liquid nitrogen。 Fatty Acids in Erythrocytes At baseline, erythrocyte n-3 PUFA levels were similar amo...

摘要：Obesity and high neutrophil counts also worsened the PM effects with or without GSTM1。 Statins are a widely prescribed class of drugs originally developed for their lipid-lowering properties, but ...

摘要：Pathology and Physiology Research Branch and Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Genetics and Developmen...

摘要：Statistical Analysis The association between pollutants and out-of-hospital coronary deaths was investigated with the case-crossover design (18)。 Coronary heart disease death and sudden cardiac de...

摘要：Proteomic profiles were calibrated, binned, and normalized before analysis。 Bronchial epithelial lesions were graded according to the World Health Organization nomenclature (18)。 Proteomic Analys...

摘要：Divisions of Environmental Health and Biostatistics, Department of Preventive Medicine, and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, C...

摘要：Ductus ligation requires a thoracotomy in small, critically ill infants。 Effect of patent ductus arteriosus on water accumulation and protein permeability in the premature lungs of mechanically ve...

摘要：Prostacyclin, a metabolite of arachidonic acid, has vasoprotective effects, including vasodilation, antiplatelet aggregation, and inhibition of smooth muscle cell proliferation (5–8)。 Prostacycli...

摘要：Institutes of Virology and Pathology, Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany ABSTRACT Rationale: In addition to Kaposi‘s sarcoma, Kaposi‘s sarcoma–associate...

摘要：University of Chicago Hospitals, Chicago, Illinois Duke University Medical Center, Durham, North Carolina University of Alabama, Birmingham, Alabama University of Michigan, Ann Arbor, Michigan Colu...

摘要：and Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin ABSTRACT Rationale: Cross-sectional association has been reported between sleep-disordered breathing (SDB) ...

摘要：Department of Infectious Diseases and Department of Histopathology, Imperial College, Hammersmith Campus, London School of Biological Sciences, University of East Anglia, Norwich, United Kingdom AB...

摘要：TB Center, The Public Health Research Institute, Newark, New Jersey。 Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York。 New approaches to ...