2003年第63卷第1期 39康复网|医源世界|http://www.39kf.com/

Activation of Microsomal Glutathione S-Transferase by Peroxynitrite
摘要：IntroductionTopAbstractIntroductionExperimental ProceduresResultsDiscussionReferencesGlutathione S-transferases (GSTs) play an important role in the detoxification of numerous carcinogenic, mutagen...
07-05-15
All-trans-Retinoic Acid Binds to and Inhibits Adenine Nucleotide Translocase and induces Mitochondrial Permeability Transition
摘要：ResultsTopAbstractIntroductionMaterials and MethodsResultsDiscussionReferencesHeart MPT Activity Is Regulated by Retinoic Acids。 Effects of Retinoic Acids on ANT Activity。atRA Binds to ANT。
07-05-15
Assessment of the Effect of Phosphorylated Metabolites of Anti-Human Immunodeficiency Virus and Anti-Hepatitis B Virus Pyrimidine Analogs on the Behavior of H
摘要：Effect of Pyrimidine Analog Monophosphates on dCMP Deamination。Effect of Pyrimidine Analog Triphosphates on dCMP Deaminase。ommittedEffect of deoxycytidine analog triphosphates on dCMP deaminase a...
07-05-15
Breast Cancer Resistance Protein (BCRP/ABCG2) Induces Cellular Resistance to HIV-1 Nucleoside Reverse Transcriptase Inhibitors
摘要：), and Department of Cancer Chemotherapy, Institute for Cancer Research (T。 and Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan ...
07-05-15
Bryostatin 1 and UCN-01 Potentiate 1--D-Arabinofuranosylcytosine-Induced Apoptosis in Human Myeloid Leukemia Cells through Disparate Mechanisms
摘要：), Medical College of Virginia, Virginia Commonwealth University, Richmond, VirginiaAbstractTopAbstractIntroductionMaerials and MethodsResultsDiscussionReferencesThe effects of the PKC activator an...
07-05-15
Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo
摘要：Model parameters are defined in , and the corresponding equations are given infig。ommittedModel variables fig。ommitted Model equations。Model simulations were run on MATLAB using the ode15s subro...
07-05-15
Chemical Synthesis of MT1 and MT7 Muscarinic Toxins: Critical Role of Arg-34 in Their Interaction with M1 Muscarinic Receptor
摘要：Commissariat à l‘Energie Atomique, Département d‘Ingénierie et d‘Etude des Protéines, Gif-sur-Yvette, FranceAbstractTopAbstractIntroductionMaterials and MethodsResultsDiscussionReferencesTwo...
07-05-15
Cloning, Sequencing and Tissue Distribution of Rat Flavin-Containing Monooxygenase 4: Two Different Forms Are Produced by Tissue-Specific Alternative Splicing
摘要：Sequencing was performed by Genome Express (Grenoble, France)。ResultsTopAbstractIntroductionMaterials and MethodsResultsDiscussionReferencesPCR-Based Cloning of cDNA。 Sequencing of Two Different ...
07-05-15
Coexpression of -Opioid Receptors with µ Receptors in GH3 Cells Changes the Functional Response to µ Agonists from Inhibitory to Excitatory
摘要：)AbstractTopAbstractIntroductionMaterials and MethodsResultsDiscussionReferencesGH3 cells show spontaneous activity characterized by bursts of action potentials and oscillations in [Ca2+]i。 In GH3...
07-05-15
Detection of Thymidylate Synthase Modulators by a Novel Screening Assay
摘要：Grace Cancer Drug Center, Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New YorkAbstractTopAbstractIntroductionaterials and MethodsResultsDiscussionReferences...
07-05-15
Down-Regulation of Hepatic Nicotine Metabolism and a CYP2A6-Like Enzyme in African Green Monkeys after Long-Term Nicotine Administration
摘要：)AbstractTopAbstractIntroductionMaterials and MethodsResultsDiscussionReferencesNicotine metabolism is decreased in smokers compared with nonsmokers, but the mechanism(s) responsible for the slower...
07-05-15
Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of the CYP2H1 Gene
摘要：Our studies using the adenovirus E1A wild-type protein, which inhibits the coactivators cAMP response element binding protein (CBP) and CBP associated factor (p/CAF), provide evidence for the invol...
07-05-15
Growth Inhibition by the Farnesyltransferase Inhibitor FTI-277 Involves Bcl-2 Expression and Defective Association with Raf-1 in Liver Cancer Cell Lines
摘要：Lee Moffitt Cancer Center and the Department of Biochemistry and Molecular Biology, University of South Florida, Tampa, Florida (S。 In the present study, we investigated the effects of the farnesy...
07-05-15
Key Structural Features of Nonsteroidal Ligands for Binding and Activation of the Androgen Receptor
摘要：Nonsteroidal compounds with diverse structural features demonstrated a wide range of binding affinity for the AR。 Nonsteroidal antiandrogens, such as flutamide (Eulexin), nilutamide (Anandron), an...
07-05-15

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