摘要：), Hunter College, City University of New York, New York, New York Abstract Overexpression of endoplasmic reticulum-localized NADPH: cytochrome c (P450) reductase (NPR) in Chinese hamster ovary cel...

摘要：) Abstract Glutamatergic neurotransmission plays a critical role in addictive behaviors, and recent evidence indicates that genetic or pharmacological inactivation of the type 5 metabotropic glutam...

摘要：) Abstract Allelic variations in CYP1B1 are reported to modulate the incidence of several types of cancer。 To provide a mechanistic basis for this association, we investigated the impact of nonsil...

摘要：Results TCDD Induces IGFBP-1 mRNAs in Cultured Human Hepatocytes。 TCDD Induces IGFBP-1 mRNA and Protein in HepG2 Cells。 Growth Horm IGF Res 13: 316eC321。

摘要：), Cross Cancer Institute, Edmonton, Alberta, Canada Abstract Antifolates such as methotrexate, raltitrexed, and pemetrexed are among the most effective and widely used anticancer drugs。 Binding o...

摘要：Binding Assays。 Binding parameters were determined with the Prism software (GraphPad Software, Inc。 Binding Assays。 Binding assays led, however, to a previously unreported observation either in ...

摘要：Departments of Ophthalmology and Visual Sciences and Biological Sciences, University of Illinois at Chicago, Chicago, Illinois Abstract Picrotoxin is a plant alkaloid that is often used to block th...

摘要：1 activation and inactivation in Xenopus laevis oocytes, and suggested that they pertain to the assembly/disassembly of the Syx/SNAP-25 (t-SNARE) complex。 Furthermore, the t-SNARE complex was show...

摘要：Department of Pharmacology, Medical Science Center, University of Wisconsin, Madison, Wisconsin Abstract CYP1B1 activates polycyclic aromatic hydrocarbon carcinogens in cAMP-regulated tissues such ...

摘要：An Aromatic Amino Acid Residue at Position 1519 Is Required for the Action of Pyrethroids。 He H, Chen AC, Davey RB, Ivie GW, and George JE (1999) Identification of a point mutation in the para-typ...

摘要：Pommier Y, Leteurtre F, Fesen MR, Fujimori A, Bertrand R, Solary E, Kohlhagen G, and Kohn KW (1994a) Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors。

摘要：Sp1, EGR-1, and Sulindac Sulfide-Induced NAG-1 Expression。 Expression of EGR-1 Is Induced by Sulindac Sulfide。 Baek SJ, Kim JS, Nixon JB, DiAugustine RP, and Eling TE (2004) Expression of NAG-1, ...

摘要：Electrophoresis (SDS-Polyacrylamide Gel Electrophoresis), Immunoblotting, and Protein Quantification。 Proteins were separated by SDS-polyacrylamide gel electrophoresis on 12% polyacrylamide gels (...

摘要：Institut fe Pharmakologie und Toxikologie, Technische Universitt Mechen, Mechen, Germany Abstract Phosphatidylinositol 3-kinase (PI3-K) is involved in physiological processes of cellular proliferat...

摘要：In Vitro Transport Assays。 Transport assays were performed using the rapid filtration method essentially as described previously (Leier et al。 Transport of cAMP and cGMP by MRP8。 Transport of Gl...

摘要：), National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, North Carolina Abstract TRPC3 s a nonselectiv...

摘要：Adenylyl cyclases comprise a large family of enzymes that catalyze the synthesis of cyclic AMP from ATP。 Adenylyl cyclases constitute the “effector“ component of transmembrane signaling pathways...

摘要：Analysis of Poly(ADP-Ribose)-Modified Proteins。 Results N3-A Methylation Induces PARP-1 Activation, Early DNA Fragmentation, and Loss of Mitochondrial Membrane Potential。 Alano CC, Ying W, and Sw...

摘要：Trp1531 Substitutions Altered Neither External Nor Cytoplasmic LA Access。 Aromaticity Is Critical for Na+ Channel Function and Pharmacology。 Balser JR, Nuss HB, Chiamvirnonvat N, Peerez-Garce猘 M...

摘要：Results Propafenones Are Substrates of P-Glycoprotein。 Identification of Substrate-Binding Domains of P-gp。 Relating the Substrate Photoaffinity Labeling Information to the 3D Atomic Detail Model...

摘要：-Arrestins contain one amphipathic and potentially amphitropic (membrane-targeting) -helix (helix I) that may promote translocation to the membrane or influence receptor internalization or traffick...

摘要：Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom (D。) Cardiothoracic Surgery (Respiratory Pharmacology Group), National Heart and Lung Institut...

摘要：Human cytosolic sulfotransferases (SULTs) are phase II detoxification enzymes that catalyze the biotransformation of a host of endogenous and exogenous substrates (Jakoby and Ziegler, 1990)。 Human...

摘要：) Abstract Adenosine A2A and dopamine D2 receptors have been shown previously to form heteromeric complexes and interact at the level of agonist binding, G protein coupling, and trafficking。 Funct...

摘要：Department of Pharmacology, Yale University, New Haven, Connecticut Abstract Our previous studies suggested that the dNTP/dNDP transporter systems that exist in mitochondria for transporting dNTP/d...