摘要：Valproic acid derivatives were synthesized according to methods described elsewhere (Hauck et al。 Teratogenic Potency of VPA Derivatives。 Gravemann U (2002) Synthesis of Achiral, Racemic and Enan...

摘要：Department of Medicine, University of Virginia, Charlottesville, Virginia Abstract Adenosine promotes tissue protection and repair through four general modes of action: increased oxygen supply/dema...

摘要：Palmitoylation has been shown to affect several aspects of GPCR function, including the efficiency and selectivity of G-protein coupling, receptor phosphorylation and desensitization, endocytosis, ...

摘要：Vascular endothelial growth factor receptor [fetal liver kinase/kinase-inserting domain-containing receptor (KDR)] is a tyrosine kinase receptor and has been strongly implicated in tumor angiogenes...

摘要：Departments of Cellular and Molecular Pharmacology, Pharmaceutical Chemistry Biopharmaceutical Sciences the Liver Center, University of California, San Francisco, San Francisco, California Abstract...

摘要：Results Antiangiogenic Activity of trans-Resveratrol Derivatives。 3,5,4‘-Trimethoxystilbene As an Endothelial Cell Microtubule-Destabilizing Agent。 Cao Y, Cao R, and Brakenhielm E (2002) Antiang...

摘要：Glutamate receptor agonists were purchased from Tocris Cookson Inc。 Modeling of the Glutamate Binding Site in the NR2A NMDA Receptor Subunit。 The Ligand Binding Site in the NR2A Receptor Subunit。...

摘要：Cellular experiments showed that treatment by MA in the presence of cisplatin sensitized the Pol -overexpressing cisplatin-resistant 2008C135。 Cellular proliferation was expressed as the ratio of ...

摘要：-Adrenergic receptors (ARs) are prototypic GPCRs that have been studied in detail, particularly with respect to their agonist-induced internalization (Claing et al。 Results Real-Time Imaging of Gs...

摘要：Anthracyclines are effective anticancer drugs whose use is limited by a chronic cardiotoxicity for which the mechanism is poorly understood (Zucchi and Danesi, 2003)。 Anthracyclines, such as doxor...

摘要：Department of Ion Channels, Merck Research Laboratories, Rahway, New Jersey (L。 Stichodactyla helianthus peptide (ShK), isolated from S。 helianthus venom and a known high-affinity blocker of Kv1。...

摘要：Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia Abstract Glutamate transporters regulate extracellular concentrations of glutamate, an excitatory neuro...

摘要：A prime example of this essence is the GPCR superfamily, embodied by the seven transmembrane spanning domains that engender ligand specificity and functional integrity。 To further illustrate this ...

摘要：Laboratory of Immunology and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shillimdong, Kwanakgu, Seoul, Korea Abstract Endothelial monocyte-activat...

摘要：Pharma Research CNS, Bayer HealthCare AG, Wuppertal, Germany Abstract Many acute and chronic neurodegenerative diseases are characterized by a localized inflammatory response and constitutive activ...

摘要：) Abstract The plant lectins from Hippeastrum hybrid (HHA) and Galanthus nivalis (GNA) are 50,000-D tetramers showing specificity for -(1,3) and/or -(1,6)-mannose oligomers。 They inhibit HIV-1 inf...

摘要：1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active form of vitamin D, plays a major role in bone metabolism and in calcium and phosphate homeostasis。 Results Effects of 1,25-(OH)2D3 ...

摘要：GFP11 for the Detection of Novel Anti-HIV Compounds。

摘要：) Abstract We have previously reported that endocytic sorting of ETA endothelin receptors to the recycling pathway is dependent on a signal residing in the cytoplasmic carboxyl-terminal region。 Th...

摘要：), Weill Medical College of Cornell University, New York, New York Abstract General anesthetics have marked effects on synaptic transmission, but the mechanisms of their presynaptic actions are unc...

摘要：Institute of Anatomy and Cell Biology, University of Wezburg, Wezburg, Germany Abstract The affinity of corticosterone to organic cation transporters (OCTs) is subtype- and species-dependent。 For ...

摘要：The Human OAT2 Promoter Is Transactivated by HNF-4 through the DR-1 Element。 Hagenbuch B and Meier PJ (2004) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classifi...

摘要：Departments of Pharmacology and Cell and Developmental Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Abstract Internalization, recycling and ...

摘要：Nicotine was given in drinking water to provide a long-term yet intermittent treatment。 Nicotine is an important modulator of nAChR expression。 Nicotine was given in the drinking water because th...

摘要：Effect of 3,5-DBr-L-Phe on GABA-ergic Transmission and Elicited Action Potentials。 Moghaddam B and Jackson ME (2003) Glutamatergic animal models of schizophrenia。

摘要：) Abstract Calcitonin (CT) receptors dimerize with receptor activity-modifying proteins (RAMPs) to create high-affinity amylin (AMY) receptors, but there is no reliable means of pharmacologically d...

摘要：Angiotensin II (Ang II) has direct effects on endothelial and vascular smooth muscle cells (VSMCs) and plays a key role in the initiation and amplification of pathobiological events that lead to va...

摘要：Results Mutation Scanning of Amino Acids Comprising the Presumed Fourth Transmembrane Helix of rOCT1。 Substrate concentration-dependence of mutant S220I revealed a statistically significant reduct...

摘要：Surprisingly, electrophoretic mobility shift analysis and chromatin immunoprecipitation assays revealed that Sp3 and its isoforms (M1 and M2) were specifically bound to the Sp binding sequence。 In...

摘要：) Abstract Cephalostatin 1 is a marine product that induces a novel cytochrome c-independent apoptotic pathway in Jurkat leukemia T cells (Cancer Res 63:8869eC8876, 2003)。 Here, we show that overe...

摘要：) Abstract Agonist activation regulates reciprocal interactions of spinophilin and arrestin with the 2A- and 2B -adrenergic receptor (AR) subtypes via their 3i loop。 Agonist activation of 2A-AR pr...

摘要：One possible level of interaction is between CB1 cannabinoid and D2 dopamine receptors。 Here, we demonstrate that a regulated association of CB1 and D2 receptors profoundly alters CB1 signaling。 ...

摘要：Results Potentiation of P2Y1 Receptor-Evoked Ca2+ Release by Extracellular K+。 Potentiation of ADP-dependent Ca2+ responses by an increase of extracellular K+ was still observed in Ca2+-free mediu...

摘要：Structural analysis using a three-dimensional homology model of the ligand-binding domain of the receptor has revealed that the Met852 residue of the ligand-binding cavity faces the C7 substituent ...

摘要：Hagenbuch B and Meier PJ (2004) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional pro...

摘要：39 in healthy blood donors was identified in the putative TATA box of the UGT1A7 gene, reducing promoter activity to 30%。 We identified a novel reduced-function TATA box SNP of the UGT1A7 gene tha...

摘要：Departments of Environmental Health (L。 Activation of the AhR and transcription of AhR-regulated genes typically are required for the manifestation of environmental chemical-induced immunotoxicity...

摘要：Institute of Pharmaceutical Chemistry, University of Frankfurt, Frankfurt, Germany Abstract U-73122 (1-[6-[[17--3-methoxyestra-1,3,5(10)-trien-17-yl]amino] hexyl]-1H-pyrrole-2,5-dione) is a widely ...

摘要：Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands Abstract Nitrofurantoin is a commonly used urinary tract antibiotic prescribed to lactating woman。 Ou...

摘要：Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands Abstract The breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette drug efflux tran...