摘要：) Abstract Reactive oxygen species (ROS) are produced by all aerobic cells and have been implicated in the regulation of diverse cellular functions, including intracellular signaling, transcription...

摘要：Histone Acetylases and Deacetylases: Classification and Function The equilibrium of steady state acetylation is tightly controlled by the antagonistic effect of both HATs and HDACs, which in turn r...

摘要：5 channels and competition between drug-binding and N-type inactivation。 The holding potential was eC80 mV and the interpulse interval for all voltage clamp protocols was 10 s or slower to allow c...

摘要：Nitric oxide is an endogenous regulator of different cellular functions, including vascular tone (Gruetter et al。 Nitric oxide release from DPN, Me-DPN, and methoxime-DPN was quantified based on a...

摘要：) Abstract In the present investigation, we studied the modulating effects of several tea catechins and bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase (DNMT) a...

摘要：Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany Abstract Hepatobiliary elimination of many organic anions is initiated by OATP1B1 (OATP2, LST-1, OATP-C), OATP1B3 (OATP8), and...

摘要：Adenylate Cyclase Experiments。 Adenylate cyclase activation by agonists was measured in whole HA-hD1 HEK cells rather than membranes to make the parallel with the internalization as physiologicall...

摘要：Department of Biochemistry and Molecular Biology and the UF Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida Abstract SN1-alkylating agents, such as the mutagen...

摘要：), College of Medicine, National Taiwan University, Taipei, Taiwan Abstract Diosgenin, extracted from the root of wild yam (Dioscorea villosa), has been reported to demonstrate an opportunity for m...

摘要：) Abstract We report here that overexpression of Rad23, a protein related to the ubiquitin-proteasome system, renders yeast cells resistant to methylmercury。 Rad23 has three domains: two ubiquitin...

摘要：Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota Abstract KDN21 is a bivalent ligand that contains and opioid antagonist pharmacophores linked...

摘要：Department of Environmental Health, Boston University School of Public Health (H。 Bone marrow was flushed from the femurs of 4- to 6-week-old male mice。 Bone marrow B cells were harvested and was...

摘要：Activation of MAPKs by PPAR Ligands MAPKs alter the activity of a diverse array of transcription factors and the expression of their conjugate genes and represent one of the major cellular mechanis...

摘要：) Abstract -Ketoisocaproate directly inhibits the ATP-sensitive K+ channel (KATP channel) in pancreatic -cells, but it is unknown whether direct KATP channel inhibition contributes to insulin relea...

摘要：Thyrotropin (TSH) signaling through its receptor mediates the paracrine control of thyroid function。 Sialylation of membrane proteins, including the thyroid peroxidase, may participate in the TSH-...

摘要：) Abstract We demonstrated previously that ginsenoside Rg3 (Rg3), an active ingredient of Panax ginseng, inhibits brain-type Na+ channel activity。 In this study, we sought to elucidate the molecul...

摘要：References Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, and Williams JT (2002) mu-Opioid receptors: ligand-dependent activation of potassium conductance, dese...

摘要：) Abstract The 90-kDa heat shock protein (hsp90) regulates the stability and function of many client proteins, including members of the NO-cGMP signaling pathway。 The 90-kDa heat shock protein (hs...

摘要：Icilin activated the hENaC homomer as well as hENaC, whereas the hENaC current was slightly reduced by icilin。 Icilin was dissolved in dimethyl sulfoxide at the concentration of 100 mM as a stock ...

摘要：Department of Anesthesiology, Department of Physiology and Biophysics and Center for Single Molecule Biophysics, University at Buffalo, Buffalo, New York Abstract N-Methyl-D-aspartate (NMDA) recept...

摘要：Geranylgeranylacetone (GGA), a clinically used antiulcer drug, can protect gastric mucosa against lesion formation mediated by NSAIDs。 In this study, we show that GGA acts to stabilize membranes a...

摘要：This “DRY“ motif has been described to provide a pivotal role in signal transduction of GPCRs。 Together, these observations have given rise to the possibility that the DRY motif may not have the...

摘要：), University of Oxford, Oxford, United Kingdom Abstract Ionotropic GABA receptors are abundant in both vertebrate and invertebrate nervous systems, where they mediate rapid, mostly inhibitory syna...

摘要：NO Inhibits ET-1-Induced AP-1 Transcriptional Activity。 Calderone A, Thaik CM, Takahashi N, Chang DL, and Colucci WS (1998) Nitric oxide, atrial natriuretic peptide and cyclic GMP inhibit the grow...

摘要：Keilhoff G, Fansa H, and Wolf G (2002) Neuronal nitric oxide synthase is the dominant nitric oxide supplier for the survival of dorsal root ganglia after peripheral nerve axotomy。 Kromer LF (1987)...

摘要：) Abstract Estrogens demonstrate vasoprotective activity in many experimental models。 Estrogens have been demonstrated to inhibit atherosclerosis, an effect that is correlated with their well char...

摘要：) Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, Irvine, California (V。 Mitochondrial dysfunction is implicated in the etiology of vascular disease...

摘要：(2001) Binding of correolide to the K(v)1。

摘要：Campiani G, De Angelis M, Armaroli S, Fattorusso C, Catalanotti B, Ramunno A, Nacci V, Novellino E, Grewer C, Ionescu D, et al。 Campiani G, Fattorusso C, De Angelis M, Catalanotti B, Butini S, Fat...