摘要：We have used a murine model of asthma to evaluate the effect of L-2-oxothiazolidine-4-carboxylic acid (OTC), a prodrug of cysteine that acts as an antioxidant, more specifically in the increase of ...

摘要：1320) provide the results of the first comprehensive investigation of the expression pattern of the Src family of nonreceptor tyrosine kinases (SFK) in mouse embryonic stem (ES) cells。 They found ...

摘要：HTFC Screening of the FPR-Focused Compound Collection。 Secondary Screening for Agonist Activity。 Secondary Screening to Confirm Antagonist Activity。

摘要：Cancer Biology Program (L。), Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia Abstract Targeted inhibition of oncogenes in tumo...

摘要：LIF and other growth factors are linked to the activation of the Src family of cytoplasmic protein-tyrosine kinases (SFKs), which consists of eight members having shared structural architecture。 I...

摘要：) Abstract Comparative models of the extracellular and transmembrane domains of GABAA receptors in the agonist-free state were generated based on the recently published structures of the nicotinic ...

摘要：Roscovitine, MK801, -conotoxin GVIA (CTx-GVIA), -conotoxin MVIIC (CTx-MVIIC), -agatoxin IVA (Aga-IVA), tetanus toxin (TnTx), nimodipine, nifedipine, cyclosporin A, concanamycin A1, bafilomycin, and...

摘要：Cigarette smoke is the major etiological factor in the pathogenesis of chronic obstructive pulmonary disease and is associated with increased risk of lung cancer (Burns, 2003)。 Cigarette smoke evo...

摘要：Department of Biochemistry, the Biotechnology Research Institute, and the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Abstract...

摘要：), McGill University, Montréal, Québec, Canada Abstract Tirapazamine (TPZ) is an anticancer drug that targets topoisomerase II。 TPZ is preferentially active under hypoxic conditions。 Under aero...

摘要：Nicotinic receptor signaling regulates DAT gene transcription in the midbrain (Li et al。 Mice also received the dopamine receptor antagonist haloperidol (2。 Mice were decapitated, brains were rem...

摘要：Department of Pharmacology, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria Abstract Presynaptic inhibition of transmitter release is commonly mediat...

摘要：Results Activation of Group I mGlu Receptors Increases 2-AG Levels in Brain Slice Cultures。 mGlu5 Receptor Activation Mediates 2-AG Formation。 Brain Res Mol Brain Res 48: 259-269。 Rouach N and N...

摘要：Molecular Features for Interaction。 Cations with intermediate hydrophobicity (e。 Cations that are more hydrophilic [low Log P (e。 Koepsell H, Schmitt BM, and Gorboulev V (2003) Organic cation tr...

摘要：Human Trx and mouse Trx antibody were obtained from MBL International (Watertown, MA) and Redox Bioscience (Kyoto, Japan), respectively。 Western Blotting of Prosurvival Proteins。 The Role of Trx ...

摘要：Results Modification of -Tubulin Migration Properties by ICEU。 -Tubulin Alkylation Demonstrated by MALDI-TOF-MS Analysis of Intact Proteins。 -Tubulin Alkylation Does Not Result from Cys Modificat...

摘要：) Abstract Scavenger receptors on sinusoidal liver endothelial cells (SECs) eliminate potentially harmful modified proteins circulating through the liver。 Scavenger receptors were first described ...

摘要：Department of Pharmacology, University College London, London, United Kingdom Abstract Recent studies have shown that RIC-3, originally identified in Caenorhabditis elegans as the protein encoded b...

摘要：), University Hospital, University of Zürich, Zürich, Switzerland Abstract PEGylation is an attractive strategy to enhance the therapeutic efficacy of proteins with a short serum half-life。 Howe...

摘要：), Queen‘s University, Kingston, Ontario, Canada Abstract Multidrug resistance in tumor cells may be caused by reduced drug accumulation resulting from expression of one or more proteins belonging...

摘要：Department of Cellular Signaling (J。 Mastoparan inhibited UTP-induced increase in [Ca2+]i and phosphoinositide hydrolysis in a concentration-dependent manner。 Mastoparan changed the localization ...

摘要：Chimeric receptors, composed of 7 sequence from the N terminus to the start of M1 followed by 5HT3A receptor sequence, form functional homopentameric receptors when expressed in mammalian cells (Ei...

摘要：) Abstract We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-fluoro...

摘要：Materials and Methods Drug and Cell Culture。 Anticancer Drug Des 14: 179-186。 Expert Opin Investig Drugs 12: 1843-1853。 Anticancer Drugs 13/1: S3-S6。

摘要：Tachykinins belong to a family of neuropeptides that share a common C-terminal sequence, Phe-Xaa-Gly-Leu-Met-NH2, that is crucial for interaction with their receptors (Severini et al。 Materials an...

摘要：Rats were randomized into six groups (n = 5 rats/group): 1) sham-operated animals treated with vehicle [20% hydroxypropyl--cyclodextrin (CDX)] (Sigma, St。 Profiling the RNA changes associated with...

摘要：Ligand and RXR-Dependent CAR3-Mediated Transactivation of CYP2B6 and CYP3A4 Reporters。

摘要：The most potent and “drug-like“ compound of this series, 5-(4-phenoxybutoxy)psoralen (PAP-1), blocks Kv1。 PAP-1 is 23-fold selective over Kv1。 PAP-1 does not exhibit cytotoxic or phototoxic eff...

摘要：) Abstract The G-protein-coupled receptor GPR109A (HM74A/PUMA-G) has recently been shown to function as a receptor for nicotinic acid (niacin) and to mediate its antilipolytic effects。 Nicotinic a...