摘要：【关键词】 Important Role The role of Mrp2, Bcrp, and P-glycoprotein in the biliary excretion of acetaminophen sulfate (AS) and glucuronide (AG), 4-methylumbelliferyl sulfate (4MUS) and glucuro...

摘要：【关键词】 Neurotoxicity This study investigated the role of cellular antioxidant defense mechanisms in modulating the neurotoxicity of domoic acid (DomA), by using cerebellar granule neurons (...

摘要：【关键词】 H+-Linked Neuroblastomas produce high amounts of lactic acid and upregulate the H+-linked monocarboxylate transporter isoform 1 (MCT1/SLC16A1)。 We found elevated MCT1 mRNA levels in...

摘要：【关键词】 Endogenous Hepatic Expression The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that acts as an environmental sensor by binding to a variety of xenobioti...

摘要：【关键词】 Analysis Although repression of inflammatory gene expression makes glucocorticoids powerful anti-inflammatory agents, side effects limit usage and drive the search for improved gluco...

摘要：【关键词】 YM-244769 We investigated the pharmacological properties and interaction domains of N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide (YM-244769), a novel potent Na+/...

摘要：【关键词】 Methamphetamine-Induced Sensitization Enhancements in behavior that accompany repeated, intermittent administration of abused drugs (sensitization) endure long after drug administrat...

摘要： Fozzard HA, Lee PJ, and Lipkind GM (2005) Mechanism of local anesthetic drug action on voltage-gated sodium channels。 Starmer CF, Grant AO, and Strauss...

摘要：Molecular Devices, Sunnyvale, CA)。), Faculty of Science, and the Maurice Wilkins Centre for Molecular Biodiscovery (S。

摘要：【关键词】 Role Long-term exposure to nicotinic ligands results in up-regulation of neuronal nicotinic 42 receptors in the brain and in heterologous expression systems。 Binding is increased by...

摘要：【关键词】 Point Mutations GABAB receptors are heterodimers of two subunits, GABAB1 (GB1) and GABAB2 (GB2)。 Positive allosteric modulators enhance the potency and efficacy of agonists at GABAB...

摘要：【关键词】 Laboratory 2,3-Butanedione monoxime (BDM) is widely believed to act as a chemical phosphatase。 Ferreira G, Artigas P, Pizarro G, and Brum G (1997) Butanedione monoxime ...

摘要：【关键词】 Essential Role To determine the role of C-Rel in nitric-oxide synthase-2 (NOS-2) transcriptional activation, we evaluated the effect of lipopolysaccharide and interferon- (LPS/IFN) o...

摘要：Increased cAMP formation inhibits myofibroblast differentiation and collagen production by cardiac fibroblasts, but the mechanism of this inhibition is not known。 We sought to characterize the sig...

摘要：We compared the effects of point mutations throughout TM3 on the interactions of carbachol, 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl] piperidine hydrogen chloride (AC-42), a potent structural ...

摘要：Checkpoint regulation involves multiple complex mechanisms (Kastan and Bartek, 2004) in which Chk1 and Chk2 act as critical messengers transducing DNA damage signals to checkpoint “effectors,“ in...

摘要：【关键词】 Molecular Interaction Experiments were conducted to examine the molecular basis for the high affinity and potency of a new class of 5-HT2A receptor agonists, N-benzyl phenethylamines...

摘要：【关键词】 Nuclear factor-B Nuclear factor-B (NF-B) has been recognized to play a critical role in cell survival and inflammatory processes。 Eriocalyxin B (Fig。 Nuclear extracts prepared acco...

摘要：It is noteworthy that, in our molecular model, the ECL2 enters into the cavity formed by the seven helices, as observed for rhodopsin in the X-ray structure, to interact with the C-terminal part of...

摘要：【关键词】 Stimulation Our previous studies have suggested a role for AMP-activated protein kinase (AMPK) in the induction of CYP2B6 by phenobarbital (PB) in hepatoma-derived cells (Rencurel et...

摘要：【关键词】 Ginsenoside Re 20,000 herbal products that are currently on the market, ginseng root is one of the most popular herbs (Attele et al。, 2004) and nitric oxide (NO) action (Gillis, 1997...

摘要：【关键词】 Conformational 10 µ。

摘要：In addition, the catalytic antibody offered some protective effect against cocaine-induced lethality and hypertension for low doses of cocaine in catecholamine-sensitized rats (Mets et al。 Further...

摘要：【关键词】 Pharmacological Pharmacological manipulation of gene expression is considered a promising avenue to reduce postischemic brain damage。 Histone deacetylases (HDACs) play a central rol...

摘要：【关键词】 Comparison The complex marine natural product halichondrin B was compared with NSC 707389 (E7389), a structurally simplified, synthetic macrocyclic ketone analog, which has been sele...

摘要：【关键词】 Melanocyte-Stimulating Two melanocortin receptors (MC1 and MC3R) have been identified as main transducers of the anti-inflammatory effects of natural and synthetic melanocortins。 In...

摘要：【关键词】 Bafilomycin Bafilomycin A1, a macrolide antibiotic isolated from Streptomyces species, has been used as an inhibitor of vacuolar H+ ATPase (V-ATPase)。 Bafilomycin has been also eval...

摘要：【关键词】 Nicotinic Acid-Induced Flushing The antidyslipidemic drug nicotinic acid (niacin) has been used for decades。 Nicotinic acid-induced flushing has been shown to be mediated by the nic...

摘要：【关键词】 Anticancer In an article presented in this issue of Molecular Pharmacology, Lim et al。 Bafilomycin induces HIF-1-mediated de-repression of CIP1 gene transcription and cell cycle arr...