摘要：【关键词】 Imino Imino sugars are used to treat type 2 diabetes mellitus [miglitol (Glyset)] and lysosomal storage disorders [miglustat (Zavesca)] based on the inhibition of -glucosidases and g...

摘要：【关键词】 Inhibition Airway smooth muscle (ASM) cells can act as effector cells in the initiation and/or perpetuation of airway inflammation in asthma by producing various inflammatory chemoki...

摘要：【关键词】 Functional Acyclic nucleotide phosphonates (adefovir, cidofovir, and tenofovir) are eliminated predominantly into the urine, and renal failure is their dose-limiting toxicity, partic...

摘要：【关键词】 Study Neuropeptide Y (NPY) is thought to have a significant role in the physiological control of energy homeostasis。 Effects of the Y5 Antagonist and Pair Feeding on Food Intake, Bo...

摘要：(Hydroxyethyl)urea peptidomimetics have recently been identified as a new class of transition state analog inhibitors that mimic the transition state of aspartyl protease catalysis and block -secre...

摘要：【关键词】 Nefiracetam Nicotinic acetylcholine receptors and N-methyl-D-aspartate (NMDA) receptors are known to be down-regulated in the brain of Alzheimer‘s disease patients。 We have previou...

摘要：【关键词】 1,1-Bis(3‘-indolyl)-1-(p-substitutedphenyl) 1,1-Bis(3‘-indolyl)-1-(p-substitutedphenyl)methanes (C-DIMs) containing para-trifluoromethyl, t-butyl, and phenyl groups are a novel cla...

摘要：【关键词】 2-Aminoethoxydiphenyl 2-Aminoethoxydiphenyl borate (2-APB), a commonly used blocker of IP3-induced calcium ion release and of store-operated channels, inhibits gap junction conductan...

摘要：【关键词】 Tonically Phasic and tonic inhibitory currents of hippocampal pyramidal neurons exhibit distinct pharmacological properties。 Picrotoxin and bicuculline methiodide inhibited both com...

摘要：【关键词】 Opioid G protein-coupled receptor desensitization and trafficking are important regulators of opioid receptor signaling that can dictate overall drug responsiveness in vivo。 Agonist...

摘要：【关键词】 Stabilization Adenine-uridine rich elements (AREs) play an important role in modulating mRNA stability, being the target site of many ARE-binding proteins (AUBPs) that are involved i...

摘要：【关键词】 Pharmacology We have developed a new assay for measuring epidermal growth factor receptor (EGFR) activation using the bioluminescence resonance energy transfer (BRET) technology, whi...

摘要：【关键词】 Involvement The striatum is believed to be a crucial brain region associated with drug reward。 It has been proposed that the dysfunction of Na+,K+-ATPase function is involved in mor...

摘要：【关键词】 Kinins Upon sustained insult, kinins are released and many kinin responses, such as inflammatory pain, adapt from a B2 receptor (B2R) type in the acute phase to a B1 receptor (B1R) t...

摘要：【关键词】 Agonist- The structural basis by which agonists, antagonists, and allosteric modulators exert their distinct actions on ligand-gated ion channels is poorly understood。 We used the s...

摘要：【关键词】 Synthetic T)。 Androgen ligands were manually positioned within the binding pocket in an orientation similar to that of aldosterone。 Androgen Ligands Inhibit Aldosterone-Stimulated N...

摘要：【关键词】 Nordihydroguaiaretic Nordihydroguaiaretic acid (NDGA), a well known lipoxygenase inhibitor, actually has pleiotropic effects on cells, which include cell proliferation, apoptosis, di...

摘要：【关键词】 Ethanol We have examined 122L GABAA receptor modulation by the endogenous steroids allopregnanolone (35P), pregnenolone sulfate, and -estradiol in the absence and presence of ethanol...

摘要：【关键词】 Analysis Nuclear factor-B (NF-B) is a transcription factor that plays crucial roles in inflammation, immunity, cell proliferation, and apoptosis。 Nuclear factor B (NF-B) is a transc...

摘要：【关键词】 Tumor Withaferin A (WA) is a steroidal lactone purified from medicinal plant “Indian Winter Cherry“ that is widely researched for its variety of properties, including antitumor eff...

摘要：Import of proteins from the cytoplasm into the cell nucleus is integral to the regulation of gene expression and cell growth。 Nuclear transport is mediated through specific aqueous channels presen...

摘要：【关键词】 Genomic Screening the Saccharomyces cerevisiae homozygous diploid deletion library against a sublethal concentration of cisplatin revealed 76 strains sensitive to the drug。 Deletion...

摘要：【关键词】 Sulfonylureas Most drugs currently employed in the treatment of type 2 diabetes either target the sulfonylurea receptor stimulating insulin release (sulfonylureas, glinides), or targ...

摘要：【关键词】 Acetaminophen The mechanism of action of acetaminophen is currently widely discussed。 Acetaminophen (400 mg/kg) and diclofenac (40 mg/kg) were given orally 40 min before formalin ad...

摘要：【关键词】 Species Selectivity 5-(Trifluoromethyl)-6-(1-methyl-azepan-4-yl)methyl-1H-quinolin-2-one (TMAQ) is a novel nicotinic acetylcholine receptor (nAChR) agonist with strong selectivity fo...