摘要：【关键词】 Uncovering In cells lacking expression of Ca2+-mobilizing G proteins, coexpression of human GPR40 and Gq allowed medium- and long-chain fatty acids to elevate intracellular [Ca2+]。 ...

摘要：【关键词】 Genetic Gastric lesions result from an imbalance between aggressive and defensive factors。 In this study, we compared gastric ulcerogenic response in wild-type mice and in those lac...

摘要：Constitutive Activity Does Not Drive CB1 Receptor Axonal Polarization in Hippocampal Neurons。 Preferential Endocytosis of the CB1 Receptor in the Somatodendritic Compartment Drives Its Functional ...

摘要：, the E/DRY motif), has received considerable attention with respect to regulating GPCR conformational states。 However, some class A GPCRs are resistant to CA, suggesting alternative roles for the...

摘要：【关键词】 Concurrent The Fas pathway and oxidative stress mediate neuronal death in stroke and may contribute to neurodegenerative disease。 Oral administration of 2-hydroxy-5-(2,3,5,6-tetrafl...

摘要：【关键词】 Interaction Activation of substance P receptors, which are coupled to Gq, inhibits the Kir3。 Moreover, Gq immunoprecipitates with Kir3。2 (J Physiol 564:489-500, 2005), suggesting t...

摘要：【关键词】 Constitutive The CB1 cannabinoid receptors are among the most highly expressed G protein coupled receptors (GPCRs) in the brain。 Constitutive endocytosis has been associated with co...

摘要：【关键词】 Structure Nitrogen mustard alkylating agents are important cancer drugs。 We have studied their interaction with the DNA dodecamer d(CGCGAATTCGCG)2, designated A2T2, and we provide a...

摘要：【关键词】 Activation Rodent Oatp2 is a hepatic uptake transporter for such compounds as cardiac glycosides。 Activation of cAMP-PKA pathway seems to be the underlying mechanism for the inducti...

摘要：【关键词】 Regulation The glutamate receptor adaptor protein Homer is concentrated in the postsynaptic density of excitatory synapses and is critical for normal operation of synaptic transmissi...

摘要：【关键词】 Structure-Based Glutathione depletion represents a potentially important strategy to sensitize tumors to cytotoxic drugs。 Comparison of the 3D Model of Human -GCS with the Crystal S...

摘要：【关键词】 Protein Sympathetic premotor neurons for the maintenance of vasomotor tone are located in rostral ventrolateral medulla (RVLM)。 Isolation of Membranous, Cytosolic, or Mitochondrial ...

摘要：【关键词】 Conjugated The regulation of glycogen synthase activity by bile acids in primary hepatocytes and in the intact liver was investigated。 Bile acids (deoxycholic acid, DCA。 TCA, but n...

摘要：【关键词】 Methylmercury-Induced The relationship between increased intracellular calcium concentration ([Ca2+]i) and changes in spontaneous synaptic current frequency caused by the neurotoxica...

摘要：【关键词】 Loss Treatment of many infectious diseases is under threat from drug resistance。 Infectivity of Pentamidine-Adapted T。 Induction of High-Level Pentamidine Resistance in T。 Pentami...

摘要：bis(1,3-dibutylthiobarbituric acid)trimethine oxonol [DiSBAC4(3)], bis(barbituric acid)pentamethine oxonol [DiSBAC0(5)], bis(3-cyano-1-ethyl-4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine)trimethine...

摘要：【关键词】 Function We hypothesized that the function of both sinusoidal and canalicular transporters importantly controls the concentrations of organic anions within normal hepatocytes。

摘要：【关键词】 High-Throughput We screened a chemolibrary of drug-like molecules for their ability to activate reactive oxygen species (ROS) production in murine phagocytes, and we identified 26 no...

摘要：【关键词】 BRCA1 Tumor suppressor gene BRCA1 is frequently mutated in familial breast and ovarian cancer。 BRCA1 plays pivotal roles in maintaining genomic stability by interacting with numerou...

摘要：【关键词】 N-Terminal 2) was strongly correlated with expression。 Role of N-Terminal Sequence and Proteasomal Degradation in Expression of RGS Proteins。 Functional Activities of RGS4, RGS5, a...

摘要：【关键词】 Modulates Regulator of G protein signaling 4 (RGS4) has recently been identified as one of the genes linked to the susceptibility of schizophrenia。 However, the functional roles of ...

摘要：【关键词】 1b-Adrenoceptor Approaches to identify G protein-coupled receptor oligomers rather than dimers have been lacking。 1b-Adrenoceptor Fusions with Fluorescent Proteins。 The 1b-Adrenoce...

摘要：【关键词】 Differential Type II DNA topoisomerases are targets of acridine drugs。 Mutations H514Y, E522K, G550R, A596T, Y606C, R651C, and D661N were in the B‘ domain, and G465D and P732L were...