摘要：【关键词】 Antiproliferative We previously developed a transcription factor decoy targeting signal transducer and activator of transcription 3 (STAT3) and reported antitumor activity in both in...

摘要：【关键词】 Quantitative Agonist-mediated desensitization of the opioid receptors is thought to function as a protective mechanism against sustained opioid signaling and therefore may prevent th...

摘要：【关键词】 Post-Transcriptional Human inducible nitric-oxide synthase (iNOS) expression is regulated both at transcriptional and post-transcriptional levels。 In the present study, the effect o...

摘要：【关键词】 Activation Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter-gated ion channels that mediate synaptic transmission throughout the nervous system in vertebrat...

摘要：In this study, we have defined a new signaling pathway for the thrombin receptor protease activated receptor-1 (PAR1) in human platelets。 We show that PAR1 couples to Gi/o in human platelets and a...

摘要：【关键词】 Interaction Exciting advances have been made in the discovery of selective positive allosteric modulators of the metabotropic glutamate receptor (mGluR) mGluR5。 Glutamate is the maj...

摘要：Reactive oxygen species (ROS) are a group of reactive, short-lived, oxygen-containing species such as superoxide (), hydrogen peroxide (H2O2), hydroxyl radical (·。 Potentiation of the JNK Ac...

摘要：【关键词】 Molecular Astrocyte death may occur in neurodegenerative disorders and complicates the outcome of brain ischemia, a condition associated with high extracellular levels of adenosine a...

摘要：【关键词】 Identification Chloride transport by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel is inhibited by a broad range of substances that bind within a wide in...

摘要：【关键词】 Conformationally In the central nervous system, glutamate transporters terminate the actions of this neurotransmitter by concentrating it into cells surrounding the synapse by a proc...

摘要：【关键词】 Protean A range of ligands displayed agonism at the long isoform of the human dopamine D2 receptor, whether using receptor-G protein fusions or membranes of cells in which pertussis ...

摘要：【关键词】 Real-Time G protein-coupled receptors transmit extracellular signals into the cells by activating heterotrimeric G proteins, a process that is often followed by receptor desensitizat...

摘要：【关键词】 Maternal Protein kinase C (PKC) plays a pivotal role in cardioprotection during cardiac ischemia and reperfusion injury。 Recent studies demonstrated that prenatal cocaine exposure c...

摘要：【关键词】 Agonist-Driven Cys-loop ligand-gated ion channels assemble as pentameric proteins, and each monomer contributes two structural elements: an extracellular ligand-binding domain (LBD) ...

摘要：【关键词】 Vitamin The vitamin D receptor (VDR) mediates the biological actions of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D, which regulates calcium homeostasis, imm...

摘要：【关键词】 Analogs As a novel approach to drug discovery involving neuronal nicotinic acetylcholine receptors (nAChRs), our laboratory targeted nonagonist binding sites (i。 Noncompetitive inhi...

摘要：【关键词】 Insulin The mechanisms by which insulin modulates neuronal plasticity and pain processes remain poorly understood。 Here we report that insulin rapidly increases the function of glyc...

摘要：【关键词】 Domains Many cellular signaling pathways share regulation by protein phosphatase-2A (PP2A), a widely expressed serine/threonine phosphatase, and the heterotrimeric G protein G12。[Ab...

摘要：【关键词】 Synergistic The excessive activation of the N-methyl-D-aspartate receptor (NMDAR)/nitric oxide (NO) pathway has been proposed to be involved in the neuropathology of various neurodeg...

摘要：Prostaglandins Leukot Essent Fatty Acids 64: 241-245。[Abstract/Free Full Text] Schwarz EJ, Reginato MJ, Shao D, Krakow SL, and Lazar MA (1997) Retinoic acid blocks adipogenesis by inhibiting C/...

摘要：【关键词】 Solute-Inhibitor Human red blood cells infected with the malaria parasite Plasmodium falciparum have markedly increased permeabilities to diverse organic and inorganic solutes。

摘要：【关键词】 Reversal Antimicrotubule agents are commonly used chemotherapy drugs for the treatment of breast and other cancers。 Resistance to antimicrotubule agents is complex and includes nons...

摘要：Dopamine (DA) is the predominant catecholamine neurotransmitter in the central nervous system。 Activation of D2SR Up-Regulates DAT Function。 Dopamine D2SR Modulates DAT Function Via an ERK1/2-Dep...

摘要：【关键词】 Extracellular The nuclear receptor constitutive active/androstane receptor (CAR) is sequestered in the cytoplasm of liver cells before its activation by therapeutic drugs and xenobio...

摘要：This approach, though quite sensitive, monitors only substrate accumulation, the end result of transport, and as such gives little information about the temporal dynamics of the transport process。...

摘要：【关键词】 Activation As a member of the transient receptor potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in nociceptive function and pain stat...

摘要：Nat Rev Cancer 6: 857-866。 Semin Cancer Biol 17: 65-73。 Can J Physiol Pharmacol 80: 1015-1021。

摘要：【关键词】 Missing Links The concept of pharmacological efficacy has been much discussed recently with significant interest both in inverse agonists and in protean agonists (i。 Mechanisms of p...

摘要：【关键词】 Vitamin E The search for a selective and efficient anticancer agent for treating all neoplastic disease has yet to deliver a universally suitable compound(s)。 Vitamin E (VE) analogs...