摘要：【关键词】 Disruption The rgsRhoGEFs comprise a subfamily of three guanine nucleotide exchange factors, which function in linking heterotrimeric G-proteins to the monomeric RhoGTPase。 Deletion...

摘要：【关键词】 Antithrombotic Binding of von Willebrand factor (vWF) to platelet glycoprotein (GP) Ib-IX-V mediates platelet activation in the early stage of thrombus formation。 Kistomin, a snake ...

摘要：Characterization of Quinazolinone Derivatives as FPRL1 Ligands。 Characterization and chromosome mapping of a peptide chemoattractant receptor family。

摘要：【关键词】 Effect The effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of the phytoestrogens daidzein, genistein, and coumestrol was investigated using Bcrp-/- mice。 ...

摘要：【关键词】 Hydrocarbon The AHR locus encodes the aryl hydrocarbon receptor (AHR), a transcriptional regulator of multiple drug-metabolizing enzymes and mediator of toxicity of dioxin-like chemi...

摘要：【关键词】 Differences between Human and Rat Primary Hepatocytes in Response to The liver is central to the maintenance of glucose and lipid homeostasis, and liver X receptors (LXRs) are key re...

摘要：【关键词】 Identification Receptors, once considered a class of opioid receptors, are now regarded as a unique class of receptors that contain binding sites for a wide range of ligands, includi...

摘要：【关键词】 Gemfibrozil The present study underlines the importance of gemfibrozil, a lipid-lowering drug and an activator of peroxisome proliferator-activated receptor- (PPAR-), in inhibiting t...

摘要：【关键词】 Subunit-Specific The four N-methyl-D-aspartate (NMDA) receptor NR2 subunits (NR2A-D) have different developmental, anatomical, and functional profiles that allow them to serve differ...

摘要：【关键词】 Neutralization PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinas...

摘要：【关键词】 5-Hydroxytryptamine2C Hypothalamic proopiomelanocortin (POMC) neurons play a critical role in the regulation of energy balance, and there is a convergence of critical synaptic input ...

摘要：【关键词】 Identification Chk2 is a protein kinase involved in the ATM-dependent checkpoint pathway (http://discover。 Inhibition of Chk2 has been proposed to sensitize p53-deficient cells as w...

摘要：【关键词】 Application β-Lactamase We describe a successful application of &beta。

摘要：【关键词】 Activation Human immunodeficiency virus dementia (HIV-D) is a nonfocal central nervous system manifestation characterized by cognitive, behavioral, and motor abnormalities。 Activati...

摘要：【关键词】 β-peptide (1–40) The hepatic clearance of amyloid &beta。40) [A&beta。40)] from plasma, which is largely mediated by low-density lipoprotein receptor-related protein (LRP-1), is su...

摘要：【关键词】 Structural Neuronal nicotinic acetylcholine receptor (nAChR) signaling has been implicated in a variety of normal central nervous system (CNS) functions as well as an array of neurop...

摘要：【关键词】 Discovery We report the discovery of an osmosensitive transcriptional control of human CYP3A4, CYP3A7, and CYP3A5。[Abstract/Free Full Text] Rodriguez-Antona C, Bort R, Jover R, T...

摘要：Production of Fluorescent Fusion Protein and Subunit Constructs。 Imaging of Transfected Cells by Spinning Disc Confocal Microscopy。 Cells were imaged 2 days after transfection using a white-light...

摘要：【关键词】 Separating Glucocorticoids (corticosteroids) are highly effective in combating inflammation in the context of a variety of diseases。 Transrepression at Negative GREs。 Transrepressi...

摘要：【关键词】 Illuminating G proteins are key intermediates in cellular signaling and act in response to a variety of extracellular stimuli。 However, there is growing evidence for localization at...

摘要：【关键词】 Induction Insulin-like growth factor type I receptor (IGF-IR) is frequently overexpressed in human hepatocellular carcinoma cells (HCC), and this overexpression has been correlated w...

摘要：【关键词】 Translational Nf-E2 related factor-2 (Nrf2) is a basic leucine zipper transcription factor that binds and activates the antioxidant response element (ARE) in the promoters of many an...

摘要：【关键词】 Electrophysiological CYP2J2 is abundant in cardiac tissue and active in the biosynthesis of eicosanoids such as epoxyeicosatrienoic acids (EETs)。 Isolation of Single Ventricular Car...

摘要：【关键词】 Critical 90%。 Residues 285 to 534 are identical。

摘要：【关键词】 K+ Channels Large-conductance Ca2+- and voltage-activated K+ channels (Kca1。1/BK/MaxiK) are widely expressed ion channels。 They provide a Ca2+-dependent feedback mechanism for the ...

摘要：【关键词】 Down-Regulation Recent studies have revealed that pregnane X receptor (PXR) can function as a master regulator to control the expression of drug-metabolizing enzymes, cytochrome P450...

摘要：【关键词】 Endocannabinoid The effects of the endocannabinoid anandamide (arachidonylethanolamide, AEA) on the function of 4&beta。 Anandamide belongs to a larger group of signaling lipids cons...

摘要：【关键词】 Vivo The bisdioxopiperazines such as (+)-(S)-4,4‘-propylenedi-2,6-piperazinedione (dexrazoxane。 ICRF-187), 1,2-bis(3,5-dioxopiperazin-1-yl)ethane (ICRF-154), and 4,4‘-(1,2-dimethy...

摘要：【关键词】 -Glutamylcysteine This study aims to investigate the role of -glutamylcysteine synthetase (-GCS), the rate-limiting enzyme for glutathione (GSH) synthesis, in the c-Myc-dependent res...