摘要：【关键词】 Incensole Acetate Boswellia resin is a major anti-inflammatory agent in herbal medical tradition, as well as a common food supplement。 Leung CH, Grill SP, Lam ...

摘要：【关键词】 Repression Treatment of hyperthyroidism by thionamides is associated with immunomodulatory effects, but the mechanism of thionamide-induced immunosuppression is unclear。 T-Cell Prol...

摘要：【关键词】 Cystine-Glutamate The cystine-glutamate transporter SLC7A11 has been implicated in chemoresistance, by supplying cystine to the cell for glutathione maintenance。 In the NCI-60 cell ...

摘要：【关键词】 Regulation Expression of Urate transporter 1 (URAT1/SLC22A12) is restricted to the proximal tubules in the kidney, where it is responsible for the tubular reabsorption of urate。 Hep...

摘要：【关键词】 Prevents It is well documented that the mitogen-activated protein kinase pathway plays a pivotal role in rats with 6-hydroxydopamine (6-OHDA)-induced unilateral lesion in the nigrost...

摘要：【关键词】 Mitochondrial The multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) is studied as a candidate suicide gene for applications i...

摘要：【关键词】 Decursin Alterations in the Wnt/-catenin pathway are associated with the development and progression of human prostate cancer。 Decursin, a pyranocoumarin isolated from the Korean An...

摘要：【关键词】 Factor-Related Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent because of its tumor selectivity。 Tumor necrosis factor-relate...

摘要：【关键词】 Inhibition amiloride, with IC50 values of 0。 Study of inhibition by phenamil in the presence of previously reported inhibitor tetrapentylammonium indicates that amiloride and organi...

摘要：【关键词】 Identification Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2。 [3H]T...

摘要：【关键词】 CB1 The CB1 cannabinoid receptor is a G-protein coupled receptor that has important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection。 We report t...

摘要：【关键词】 Docosahexaenoic We investigated, in monocytic leukemia U937 cells, the effects of docosahexaenoic acid (DHA。 22:6 n-3) on calcium signaling and determined the implication of phospho...

摘要：【关键词】 N-Terminal The N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors (iGluRs) is a tetrameric protein composed of homologous NR1 and NR2 subunits, which require the b...

摘要：【关键词】 Molecular Vernakalant (RSD1235) is an investigational drug recently shown to convert atrial fibrillation rapidly and safely in patients (J Am Coll Cardiol 44:2355&ndash。 Vernakalant...

摘要：【关键词】 Resveratrol Resveratrol (trans-3,5,4‘-trihydroxystilbene), a polyphenolic compound found in plant products, including red grapes, exhibits anticancer, antioxidant, and anti-inflamma...

摘要：Equilibrium Binding and Functional Assays Binding of [3H]NMS and [3H]QNB to membrane preparations (15&ndash。 3H-Labeled Antagonist Binding and Receptor Expression Levels。 Acetylcholine Binding。[...

摘要：【关键词】 Identification The chemokine receptor 5 (CCR5), a member of the G protein-coupled receptor family (GPCR), is used by human immunodeficiency virus type 1 (HIV-1) with a R5 tropism as ...

摘要：【关键词】 Transforming Brain levels of transforming growth factor-1 (TGF-1) are increased in Alzheimer‘s disease and have been implicated in the associated cerebrovascular pathology。 We foun...

摘要：【关键词】 Mitochondria Resveratrol (RES), a natural plant polyphenol, has gained interest as a nontoxic chemopreventive agent capable of inducing tumor cell death in a variety of cancer types。...

摘要：【关键词】 Dioxin-Responsive The human CYP1A genes CYP1A1 and CYP1A2 are in a head-to-head orientation on chromosome 15。 Both CYP1A genes and CYP1B1 are transcriptionally induced by the aryl h...

摘要：【关键词】 Evidence The cytolytic ionotropic ATP receptor P2X7 has several important roles in immune cell regulation, such as cytokine release, apoptosis, and microbial killing。

摘要：【关键词】 Monitoring A limited number of whole-cell assays allow monitoring of receptor tyrosine kinase (RTK) activity in a signaling pathway-specific manner。 RTK BRET-2 assays monitor, in li...

摘要：, Biomarkers of Oxidative Stress Study, Kadiiska et al。 Rats were treated with PB, 1-ABT, or a mixture of the two (PB for 10 days, followed by a single i。[Abstract/Free Full Text] Caro AA and ...

摘要：【关键词】 Dynamin Dynamin is a GTPase enzyme involved in membrane constriction and fission during endocytosis。 Dynamin I, II, and III are all found in neurons, but dynamin I is neuron-specifi...

摘要：【关键词】 Substance P Preclinical studies suggest that substance P (SP) neurokinin 1 (NK1) receptor antagonists are efficient in the treatment of anxiety and depression。 Substance P (SP), a s...

摘要：Acetylcholine (ACh。[Abstract/Free Full Text] Dutton JL and Craik DJ (2001) -Conotoxins: Nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads。

摘要：【关键词】 More—P2X7 P2X receptors (P2XR) function as ATP-gated nonselective ion channels permeable to Na+, K+, and Ca2+, and they are expressed in a wide range of excitable, epithelial/endoth...

摘要：【关键词】 Functional ABSTRACT Top Abstract Single Receptor State Receptor。 Receptor-Based Biased Functional。 Protean Agonism Indirect Ligand-Induced Bias Receptor-Based Selectivity Should Fu...