摘要：【关键词】 Inhibition 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exhibits antiestrogenic properties, including the inhibition of estrogen-induced uterine growth and proliferation。 Uterine weig...

摘要：【关键词】 Constitutively The aim of this study was to create and characterize constitutively active mutant (CAM) histamine H1 receptors (H1R) using random mutagenesis methods to further invest...

摘要：【关键词】 Identification Delineation of peptide ligand binding sites is of fundamental importance in rational drug design and in understanding ligand-induced receptor activation。 Binding of a...

摘要：【关键词】 Differential Despite their proven antidiabetic efficacy, widespread use of peroxisome proliferator-activated receptor (PPAR) agonists has been limited by adverse cardiovascular effec...

摘要：【关键词】 High-Affinity Voltage-clamp fluorometry was performed with a cysteine-deprived mutant of rat organic cation transporter 1 (rOCT1) in which Phe483 in transmembrane -helix (TMH) 11 clo...

摘要：【关键词】 Inhibition TRPC5 channels are Ca2+-permeable nonselective cation channels activated by G-protein-coupled receptors, although the mechanisms responsible for channel activation and reg...

摘要：【关键词】 Subcellular Neuronal nicotinic acetylcholine (ACh) receptors are ligand-gated, cation-selective ion channels。 Nicotinic receptors containing 4, 6, &beta。 Receptors containing fluor...

摘要：【关键词】 Identification P2X7 receptors are distinct from other ATP-gated P2X receptors in that they are potently inhibited by submicromolar concentrations of zinc and copper。

摘要：High mobility group protein B1 (HMGB1) is a versatile protein with intranuclear and extracellular functions。 Hmgb1 Modulated Phosphorylation of p53 and H2AX Proteins after Treatment with Genotoxic...

摘要：【关键词】 Disruption Multidrug resistance protein 4 (MRP4。 Mrp4 deficiency caused decreased extracellular and increased intracellular levels of cAMP in MEF cells under normal and forskolin-st...

摘要：【关键词】 Unusual High-affinity desensitization (HAD) by nanomolar agonists was described to shape the ability of P2X3 receptors for mediating pain sensation。) Formation of the High-Affinity ...

摘要：【关键词】 Genistein Genistein has been shown to inhibit human prostate cancer (PCa) cell motility。 Endoglin has been identified as an important suppressor of PCa cell motility, and its expres...

摘要：【关键词】 Salicylate Increased systemic free fatty acids (FFA) impair insulin sensitivity。 Salicylate slightly reduces basal but completely inhibits TNF--liberated lipase activity。 Salicylat...

摘要：【关键词】 Long-Acting Addition of an inhaled long-acting &beta。2-Adrenoceptor agonists enhance GRE-dependent transcription。2-Adrenoceptor Agonists and Glucocorticoids on CRE-Dependent Transc...

摘要：【关键词】 17β-Estradiol The coordinated activity of estrogens and epidermal growth factor receptor (EGFR) family agonists represents the main determinant of breast cancer cell proliferation。...

摘要：Weiss, 1998)。 Gulmi FA, Felson D, and Vaughan ED (1998) Physiology of ureteral obstruction, in Campbell‘s Urology (Walsh PC, Retik AB, Vaughan ED, Wein A eds) pp 324-379, WB Saunders, Philadel...

摘要：【关键词】 β-Arrestin-Dependent The cellular location of extracellular signal-regulated kinases (ERKs) activated by a G protein-coupled receptor was shown to be dependent on the pathway that m...

摘要：【关键词】 Enhancement Increased need for glycolysis and glucose uptake for ATP production is observed in tumor cells, particularly in cells lacking of oxygen supply。 Because glucose is transp...

摘要：Lacosamide reduced spiking evoked in cultured rat cortical neurons by 30-s depolarizing ramps but not by 1-s ramps。 Lacosamide inhibited sustained repetitive firing during a 10-s burst but not wit...

摘要：【关键词】 Effect Cathepsin K is a lysosomal cysteine protease that is a pharmacological target for the treatment of osteoporosis。 Cathepsin K (Cat K) is highly and somewhat specifically expre...

摘要：Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein (ATR) are sensors for DNA damage that signal p53 activation。 Increased ATM, phospho-ATM (Ser1987), and ATR levels were observed...

摘要：【关键词】 Induction Vinblastine treatment in all cell lines examined causes a robust increase in c-Jun protein expression and phosphorylation and a corresponding increase in activator protein-...

摘要：【关键词】 Functional The human breast cancer resistance protein is an ATP-binding cassette (ABC) multidrug transporter that affects the bioavailability of chemotherapeutic drugs and can confer...

摘要：【关键词】 Peroxide Susceptibility to apoptosis is an essential prerequisite for successful eradication of tumor cells by chemotherapy。 Apoptosis induced by cisplatin was mediated through the ...

摘要：【关键词】 FP Prostanoid FP prostanoid receptors are G-protein-coupled receptors whose physiological activator is prostaglandin-F2 (PGF2)。 We hypothesized that activation of the human FP recep...

摘要：【关键词】 Conformational Vardenafil has higher affinity to phosphodiesterase-5 (PDE5) than sildenafil and lower administered dosage for the treatment of erectile dysfunction。 Different Confor...

摘要：【关键词】 Alternative The regulator of G-protein signaling (RGS2) contains a characteristic RGS domain flanked by short amino and carboxyl terminal sequences。 The RGS domain mediates inhibiti...