摘要：【关键词】 Regulation Type I human hepatic 3-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism。 Hu...

摘要：【关键词】 Regulation Lysophosphatidic acid (LPA), via interaction with its G-protein coupled receptors, is involved in various pathological conditions。 Semiquantitative Reverse Transcription-...

摘要：【关键词】 Efavirenz Previous biochemical studies have demonstrated that synergy between non-nucleoside reverse transcriptase (RT) inhibitors (NNRTI) and nucleoside RT inhibitors (NRTIs) is due...

摘要：【关键词】 Mitogenic Excessive smooth muscle growth occurs within the context of inflammation associated with certain vascular and airway diseases。 Effects of 0。 Guo M, ...

摘要：【关键词】 3-Methylcholanthrene The biological effects of 17&beta。 3-Methylcholanthrene is an environmental pollutant mainly formed by incomplete combustion processes with a potent ability to ...

摘要：【关键词】 Methyl 2-Cyano-3 Methyl 2-cyano-3,11-dioxo-18&beta。-olean-1,12-diene-30-oate (&beta。 Several different structural classes of PPAR agonists have been characterized, and these includ...

摘要：【关键词】 Functional Mutations in the bone morphogenetic protein (BMP) type II receptor (BMPR2) gene cause familial pulmonary arterial hypertension (FPAH), a disease characterized by excessive...

摘要：【关键词】 [3H]Org 43553 The luteinizing hormone (LH) receptor plays a pivotal role in reproduction。 The present study characterizes the binding of a new low-molecular-weight (LMW) radioligand...

摘要：Substrates used in kinetic assays were, with BPAO, SPD and BZ, and with hSSAO, MA, BZ, and 2-phenylethylamine (PEA) (Holt et al。 Radioligand Binding。 Binding of [3H]TPP+ to BPAO。 Substrates may ...

摘要：【关键词】 Transcription The peptide hormone glucagon stimulates hepatic glucose output, and its levels in the blood are elevated in type 2 diabetes mellitus。 As part of their antidiabetic eff...

摘要：【关键词】 Reduced Homocamptothecins (hCPTs) are a novel class of topoisomerase I (Top1) inhibitors with enhanced chemical stability compared with the currently used camptothecin (CPT) analogs ...

摘要：【关键词】 Impact We have identified previously a destabilizing adenine- and uracil-rich element (ARE) in the 3‘-UTR of bcl-2 mRNA that interacted with ARE-binding proteins to down-regulate bc...

摘要：【关键词】 Structural The F508del mutation impairs trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) to the plasma membrane and results in a partially functional chl...

摘要：【关键词】 Transport ATP7B is a P-type ATPase that mediates the efflux of copper。 Recent studies have demonstrated that ATP7B regulates the cellular efflux of cisplatin (DDP) and controls sens...

摘要：【关键词】 Cloning N6-dimethyladenine)。 In summary, our data show that a second mammalian DNA sequence encodes for a Gi-coupled GPCR activated by low, nanomolar concentrations of adenine。 Ade...

摘要：【关键词】 Inhibition Here, we show a novel pharmacology for inhibition of human neutrophil migration by endocannabinoids, phytocannabinoids, and related compounds。 Isolation of Neutrophils Po...

摘要：【关键词】 Dexamethasone-Mediated Human cytochrome P450 2A6 (CYP2A6) metabolizes various clinically relevant compounds, including nicotine- and tobacco-specific procarcinogens。 We investigated...

摘要：【关键词】 Role Natriuretic peptide receptor (NPR) A is composed of an extracellular domain (ECD) with a ligand binding site, a single transmembrane region, a kinase homology domain, and a guan...

摘要：【关键词】 Small G protein &beta。 Small-molecule G&beta。 Small-molecule inhibitors of PI3-kinase catalytic activity have been demonstrated to suppress joint inflammation in mouse models of in...

摘要：【关键词】 BubR1 Intrinsic or acquired resistance to chemotherapy is a major clinical problem that has evoked the need to develop innovative approaches to predict and ultimately reverse drug re...

摘要：【关键词】 Repression Activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin causes altered gene expression and toxicity。 Role of ARNT in the Mechanism of Rep...

摘要：【关键词】 Curcumin We previously demonstrated that curcumin, a polyphenolic antioxidant purified from turmeric, up-regulated peroxisome proliferator-activated receptor (PPAR)- gene expression ...

摘要：【关键词】 Functional A novel cloned polymorphism of the human concentrative nucleoside transporter hCNT3 was described and functionally characterized。 【参考文献】 Badagnani I, Chan ...

摘要：【关键词】 β1 Large-conductance Ca2+-activated K+ (BKCa) channels encoded by the Slo1 gene are ubiquitously expressed, and they play a role in regulation of many cell types。 In excitable cell...

摘要：【关键词】 Novel Large-conductance Ca2+-activated K+ (BKCa) channels regulate the physiological properties of many cell types。 Here, we show that the Slo1 subunits of BKCa channels contain a n...

摘要：【关键词】 Characterization To analyze the interaction between the neurokinin-1 (NK-1) receptor and G-protein coupled receptor kinases (GRKs), we performed bioluminescence resonance energy tran...

摘要：【关键词】 Cellular JNJ-28871063 is a potent and highly selective pan-ErbB kinase inhibitor from a novel aminopyrimidine oxime structural class that blocks the proliferation of epidermal growth...

摘要：【关键词】 Peroxisome Glucocorticoids (GCs) are effective anti-inflammatory agents widely used in the therapeutic approach to treatment of acute and chronic inflammatory diseases。 Peroxisome p...

摘要：【关键词】 Desensitization Converging evidence has suggested that anandamide (AEA), an endogenous agonist of cannabinoid (CB) receptors, can directly interact with certain types of ligand-gated...

摘要：【关键词】 Conformational The present study characterizes the methanethiosulfonate (MTS) inhibition profiles of 26 consecutive cysteine-substituted mutants comprising transmembrane (TM) helix 6...

摘要：【关键词】 Distinct The somatostatin subtype 2A (sst2A) receptor, a member of the G protein-coupled receptor superfamily, mediates many of the neuroendocrine and neuromodulatory actions of soma...

摘要：【关键词】 Cortical The neuronal circuits mediating the sedative action of diazepam are unknown。 Expression of GABAA Receptor Subunits in Mice Lacking the 1 Subunit in Forebrain Glutamatergic ...

摘要：【关键词】 Targeting Pharmacologic agents developed for cancer therapy have traditionally relied on a therapeutic ratio of effects between tumors and normal tissue。 (2005) Trastuzumab after ad...

摘要：【关键词】 Prostaglandin-Induced Inflammation contributes to pain hypersensitivity through multiple mechanisms。 Dissociation of Mouse Trigeminal Neurons。 Neurons were dissociated by triturati...