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| 药物名称 | 人蛋氨生长素 |
| 药物别名 | 人蛋氨生长素 |
| 英文名称 | Somatrem |
| 说 明 | |
| 功用作用 | Treat growth failure associated with chronic renal insufficiency up to the time of renal transplantation. Except for Serostim to stimulate linear growth of children who suffer from lack of adequate levels of endogenous growth hormone. Humatrope and Genotropin have been approved for the treatment of somatropin deficiency syndrome in adults. In adults, Humatrope produces increased lean muscle mass and exercise capacity, decreased body fat, and normalized high-density lipoprotein cholesterol levels. Humatrope, Nutropin, and Nutropin AQ for long-term treatment of short stature associated with Turner's syndrome. Serostim is approved for the treatment of AIDS wasting (i.e., cachexia). Investigational: Short children due to intrauterine growth retardation. |
| 用法用量 | Somatrem (Protropin) IM, SC Individualized. Usual: Up to 0.1 mg/kg (0.26 IU/kg) 3 times/week, not to exceed a weekly dosage of 0.30 mg/kg (about 0.90 IU/kg). The incidence of side effects increases if the dose is greater than 0.1 mg/kg.Somatropin (Genotropin) SC 0.16-0.24 mg/kg/week divided into 6 or 7 SC injections.Somatropin (Humatrope) IM, SC Adults: Individualized. lnitial: 0.006 mg/kg/day (0.018 IU/kg/day) or less SC. May be increased, depending on need, to a maximum of 0.0125 mg/kg/day (0.0375 IU/kg/day). Pediatric: 0.18 mg/kg/week (0.54 IU/kg/week) SC or IM divided into equal doses given either on 3 alternate days or 6 times a week. Maximum weekly dose is 0.3 mg/kg (0.9 IU/kg) divided into equal doses and given on 3 alternate days.Somatripin (Norditropin) SC 0.024-0.034 mg/kg 6 to 7 times a week.Somatropin (Nutropin, Nutropin aq) SC Growth hormone deficiency. Individualized. Usual: Give a weekly dose of 0.3 mg/kg (about 0.9 IU/kg). Chronic renal insufficiency. Individualized. Usual: Give a weekly dose of 0.35 mg/kg (about 1.05 IU/kg). This dose can be given up to the time of renal transplantation. Turner Syndrome. Give a weekly dose of 0.375 (or less) mg/kg (about 1.125 IU/kg) divided into equal doses 3 to 7 times/week.Somatropin (Saizen) IM, SC 0.06 mg/kg (about 0.18 IU/kg) 3 times weekly. Discontinue when epiphyses fuse.Somatropin (Serostim) SC Weight > 55 kg: 6 mg daily; 45-55 kg: 5 mg daily; 35-45 kg: 4 mg daily; less than 35 kg: 0.1 mg/kg. Give daily dose at bedtime. |
| 注意事项 | Pregnancy Category: C
Contraindications: In clients in whom epiphyses have closed. Active intracranial lesions, sensitivity to benzyl alcohol (somatrem); sensitivity to m-cresol or glycerin (diluent in Humatrope). Use of Genotropin to treat acute catabolism in critically ill clients. NOTE: Hypothyroidism (which may be induced by the drug) decreases the response to somatrem. Special Concerns: Use with caution during lactation. Concomitant use of glucocorticoids may decrease the response to growth hormone. |