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首页药品天地专业药学西药大全调节免疫功能药其它调节免疫功能药

西罗莫司

来源:hospital.health.163.com
摘要:药物名称西罗莫司药物别名西罗莫司英文名称Sirolimus说明功用作用1。Sirolimusisanimmunosuppressant。Sirolimusisusedtopreventyourbodyfromrejectingatransplantedkidney。Sirolimusmayalsobeusedforpurposesotherthanthoselistedinthismedicatio......

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药物名称   西罗莫司
药物别名   西罗莫司
英文名称   Sirolimus
说  明   
功用作用   1.Sirolimus is an immunosuppressant. Immunosuppressants decrease the effects of your body's immune system.
2.Sirolimus is used to prevent your body from rejecting a transplanted kidney. It is usually combined with a steroid medication (e.g., prednisone) and cyclosporine (Neoral, Sandimmune).
3.Sirolimus may also be used for purposes other than those listed in this medication guide.
用法用量   1.Take sirolimus exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.
2.To use the oral solution from a bottle:
*Upon first use, open the solution bottle and insert the adapter assembly (plastic tube with stopper) tightly into the bottle until it is even with the top of the bottle. Do not remove the adapter assembly from the bottle once inserted. For each use, fully depress the plunger of one of the amber syringes, then insert it tightly into the opening of the adaptor.
*Withdraw the prescribed amount of sirolimus solution by gently pulling out the plunger of the syringe until the bottom of the black line of the plunger is even with the appropriate mark on the syringe. Always keep the bottle in an upright position. If bubbles form in the syringe, empty the syringe into the bottle and repeat the procedure. If it is necessary to carry a filled syringe, place a cap securely on the syringe (the cap should snap into place) then place the capped syringe into the enclosed carrying case. Sirolimus solution can be kept in the syringe for a maximum of 24 hours at room temperature up to 25 degrees Celsius (77 degrees Fahrenheit) or refrigerated between 2 and 8 degrees Celsius (36 to 46 degrees Fahrenheit).
*Empty the prescribed amount of sirolimus from the syringe into only a glass or plastic container holding at least 2 ounces (one-quarter cup, 60 mL) of water or orange juice. No other liquids should be used to dilute the solution. Stir vigorously for one minute and drink at once. Refill the container with at least 4 ounces (one-half cup, 120 mL) more of water or orange juice, stir vigorously, and drink at once. Discard each syringe and cap after one use.
*If it is necessary to wipe clean the mouth of the bottle before returning the product to the refrigerator, wipe with a dry cloth to avoid introducing water, or any other liquid, into the bottle.
*The sirolimus solution may develop a slight haze when refrigerated. If this occurs, allow the solution to stand at room temperature and shake gently until the haze disappears. The presence of this haze does not affect the quality of the product.
3.To use the oral solution from the pouches:
*Before opening a pouch, squeeze the pouch from the neck area to push the contents into the lower part of the pouch. Fold the pouch along the marked line, then use scissors to cut along the marked line.
*Squeeze the entire contents of the pouch, into only a glass or plastic container holding at least 2 ounces (one-quarter cup, 60 mL) of water or orange juice. No other liquids should be used to dilute the solution. Stir vigorously for one minute and drink at once. Refill the container with at least 4 ounces (one-half cup, 120 mL) more of water or orange juice, stir vigorously, and drink at once.
4.Sirolimus is usually taken once a day. It is recommended that sirolimus be taken 4 hours after taking cyclosporine (Neoral, Sandimmune). Follow your doctor's instructions
5.Sirolimus can be taken either with or without food, but it is very important to take every dose of sirolimus in the same relation to food. For example, if you take sirolimus with food, you should take every dose with food. If you take sirolimus on an empty stomach, you should take every dose on an empty stomach.
6.Do not consume grapefruit or grapefruit juice during treatment with sirolimus unless your doctor specifically directs otherwise. Sirolimus can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects.
7.Your doctor may want you to have regularly scheduled blood tests while taking sirolimus.
8.If sirolimus comes into direct contact with skin or mucous membranes, wash thoroughly with soap and water. If sirolimus comes into contact with the eyes, rinse the eyes with plain water.
9.Store sirolimus bottles or pouches of oral solution in the refrigerator between 2 and 8 degrees Celsius (36 to 46 degrees Fahrenheit). Once a bottle is opened, use the contents within one month. If necessary, the pouches and bottles can be stored at room temperature up to 25 degrees Celsius (77 degrees Fahrenheit) for several days, but no longer than 30 days.
注意事项   1.Do not consume grapefruit or grapefruit juice during treatment with sirolimus unless your doctor specifically directs otherwise. Sirolimus can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects.
2.Increased susceptibility to infection and the possible development of lymphoma (cancer of the immune system) may result from the use of an immunosuppressant such as sirolimus. Discuss these risks with your doctor and avoid sources of infection.
3.Notify your doctor immediately if you develop a cough, sore throat, fever, chills, or swelling of glands. These symptoms could be early signs of an infection.
4.Tell your doctor and dentist that you are taking this medication before having surgery, starting any other medicines, or receiving any vaccinations.
If Miss a Dose: 1.Notify your doctor if you miss a dose of this medication.
Contraindications: 1.Before taking sirolimus, tell your doctor if you have
*liver disease;
*a viral, bacterial, or fungal infection;
*high blood cholesterol or triglycerides; or
*any other serious or chronic medical condition.
2.You may not be able to take sirolimus, or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above.
3.Sirolimus is in the FDA pregnancy category C. This means that it is not known whether sirolimus will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. For women who could become pregnant, effective contraception is recommended before the start of treatment with sirolimus, during treatment with sirolimus, and for 12 weeks after sirolimus therapy has been stopped.
4.It is not known whether sirolimus passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
5.Sirolimus is not approved for use by children younger than 13 years of age.
Special Concerns: 1.Increased susceptibility to infection and the possible development of lymphoma (cancer of the immune system) may result from the use of an immunosuppressant such as sirolimus. Discuss these risks with your doctor and avoid sources of infection.
2.Do not consume grapefruit or grapefruit juice during treatment with sirolimus unless your doctor specifically directs otherwise. Sirolimus can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects.
3.Tell your doctor and dentist that you are taking this medication before having surgery, starting any other medicines, or receiving any vaccinations.
作者: 2009-1-18
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