分子烙印固相萃取-毛细管电泳法分析大米中神经性毒剂降解产物

摘　要：采用自制分子烙印聚合物-固相萃取柱来分离净化实际样品大米中的神经性毒剂降解产物，并用毛细管电泳法进行检测，方法简便，准确、灵敏度高。在0.2～5.0μg/g浓度范围内，大米样品中5种神经性毒剂降解产物的标准回归曲线线性关系良好，检出限为0.05μg/g，方法的RSD小于6.20%。

关键词：分子烙印聚合物，固相萃取，毛细管电泳法，神经性毒剂降解产物，大米
分类号：065　文献标识码：A

Determination of Nerve Agent Degradation Products in Rice by Molecule Imprinting Polymer-Solid Phase Extraction andCapillary Electrophoresis

Liu Qin（Beijing Institute of Pharmacology and Toxicology, Beijing 100850）　
Zhou Yongxin（Beijing Institute of Pharmacology and Toxicology, Beijing 100850）　
Meng Zihui（Beijing Institute of Pharmacology and Toxicology, Beijing 100850）　
Wang Qingqing（Beijing Institute of Pharmacology and Toxicology, Beijing 100850）　
Hu Xuying（Beijing Institute of Pharmacology and Toxicology, Beijing 100850）　
Liu Yintang（Beijing Institute of Pharmacology and Toxicology, Beijing 100850）　

Abstract：Self-made molecule imprinting polymer-solid phase extraction column was used in extracting nerve agent degradation products in rice. The extraction was then examined by capillary electrophoresis. The method was simple, reliable and sensitive. The calibration curve showed a good linearity for the nerve agent degradation products in rice was in the concentration range of 0.2～5.0　μg/g and the detection limits were 0.05μg/g. The RSD of the method was less than 6.2%.
Keywords：Molecule imprinting polymer, solid phase extraction, capillary electrophoresis, nerve agent degradation products，rice

参考文献：

［1］Mosbach K, Ramstrom O. Bio/Technol., 1996,14:163～170
［2］Liu Qin（刘勤）, Zhou Yongxin（周永新）, Liu Yintang（刘荫棠）. Chinese J. Anal. Chem.(分析化学),1999,27(11):1341～1347
［3］Meng Zihui（孟子晖）, Wang Qinghai（王清海）, Zhu Daoqian（周道乾）, Zhou Liangmo（周良模）. Chinese J. Anal. Chem.(分析化学),1997,25（3）：349～354
［4］Liu Qin（刘勤）, Zhou Yongxin（周永新）, Tang Lihe（汤立合）,Liu Yintang（刘荫棠）. Chinese J. Anal. Chem.(分析化学),2000,28（7）：810～814

收稿日期：2000年5月12日

修稿日期：2000年11月27日

出版日期：2001年4月1日