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Abstract:A method for the determination of tiptolide in human plas ma by gas
chromatography-electron capture detection is described. An SE-54 capillary
column (30 m×0.25 mm i.d.) was used. N itroge n was used as the carrier gas.
After NaOH solution being added, the plasma was extracted with ether-chloroform
(3∶1,V/V) and
then reacted with trifluoroacetic anhy drid e. A good linearity was obtained
from 1.0 μg/L to
50.0 μg/L of
tiptolide in human plasma, r=0.999 0. The detection limit of it in plasma was 0.5
μg/L . The
average recovery was 96.3%. The method is sensitive and
precise. |
作者简介:杨丽莉(1968-),女,主管技师,电话:(025)3704178,E-mai l:yllyj@elong.com.
作者单位:杨丽莉(南京军区南京总医院临床药理科, 江苏 南京 210002) 张昕(南京军区南京总医院临床药理科, 江苏 南京 210002) 袁倚盛(南京军区南京总医院临床药理科, 江苏 南京 210002) 参考文献: [1] ZHANG Chong-pu, L Chan-yu, MA Peng-cheng,et al. Act a
Pharmaceutica Sinica,1993,28(2):110-115 |
原载于《色谱》2001 Vol.19 No.1 P.58-59
http://periodical.wanfangdata.com.cn/periodical/sp/sp2001/0101/0101ml.htm