摘要：【摘要】 Ischemic-induced cell injury results in rapid duration-dependent actin-depolymerizing factor (ADF)/cofilin-mediated disruption of the apical microvilli microfilament cores。 Because i...

摘要：There are three major UT-A isoforms found in the mouse kidney: mUT-A1, mUT-A2, and mUT-A3。 The major aim of this study was to identify the location and function of mUT-A3。 UT-A proteins were inve...

摘要：【摘要】 The purpose of this study was to evaluate the physiological significance of a tissue renin-angiotensin system in the proximal tubule of the kidney。 To accomplish this, we produced mi...

摘要：【摘要】 The effect of phosphorylated phloretins on Na + -dependent phosphate uptake into rabbit renal brush-border membrane vesicles (BBMV) was examined。 Na + -dependent phosphate uptake int...

摘要：【摘要】 Chronic renal injury can be mediated by angiotensin II (ANG II) and prostanoids through hemodynamic and inflammatory mechanisms and attenuated by individual suppression of these media...

摘要：We hypothesized that epithelial Na channel (ENaC) subunit dysregulation may be responsible for the increased sodium retention。 The protein abundance of -ENaC and -ENaC was increased in the inner s...

摘要：【摘要】 We investigated the molecular basis of progressive diabetic renal injury in db/db mice by profiling kidney gene expression。 Using high-density microarrays, we identified 482 RNA tran...

摘要：【摘要】 Primary cultures of rat inner medullary collecting duct (IMCD) cells Na + dependently import across the basolateral membrane through an undefined transport protein。 We used RT-PCR, i...

摘要：Angiostatin is a proteolytic cleavage product of plasminogen that inhibits angiogenesis, promotes apoptosis of endothelial cells, and disrupts capillary integrity。 A combination of lysine-Sepharos...

摘要：【摘要】 We previously demonstrated that dietary K intake regulates the expression of Src family PTK, which plays an important role in controlling the expression of ROMK1 in plasma membrane (W...

摘要：ACEI impairs the conversion of ANG I to ANG II, a dipsogenic hormone, and impairs the degradation of bradykinin。 The goal of this study was to examine the role of bradykinin in the polydipsia and ...

摘要：【摘要】 We used genistein (Gen) and tyrphostin 23 (Tyr-23) to evaluate the importance of tyrosine phosphorylation in norepinephrine (NE)-induced changes in intracellular free calcium concentr...

摘要：【摘要】 Although oxidative stress activates epidermal growth factor receptor (EGFR), ERK1/2, and Akt in a number of cell types, the mechanisms by which oxidative stress activates these kinase...

摘要：【摘要】 Experiments were performed in neuronal (nNOS)- and endothelial nitric oxide synthase (eNOS)-deficient mice to study the role of nitric oxide (NO) in macula densa control of renin secr...

摘要：【摘要】 The nuclear enzyme poly(ADP-ribose) polymerase (PARP) has been implicated in ischemia-reperfusion injury in many tissues under normothermic conditions。 The purpose of this study was ...

摘要：【摘要】 Edelman et al。 have empirically shown that plasma water sodium concentration ([Na + ] pw ) is equal to 1。11(Na e + K e )/TBW - 25。6 (Edelman IS, Leibman J, O‘Meara MP, Birkenfeld ...

摘要：【摘要】 The evolution of the vertebrate kidney records three occasions, each separated by about 50 million years, when fish have abandoned glomeruli to produce urine by tubular mechanisms。 T...