摘要：We hypothesized that the primary target of formate is the apical Na + /H + exchanger。 Here, we demonstrate that formate directly enhances the apical Na + /H + exchanger (NHE3) activity in mouse ki...

摘要：【摘要】 Renin release from juxtaglomerular granular cells is considered the rate-limiting step in activation of the renin-angiotensin system that helps to maintain body salt and water balance...

摘要：【摘要】 Insulin stimulates sodium transport across A6 epithelial cell monolayers。 Activation of phosphatidylinositol 3-kinase (PI 3-kinase) was suggested as an early step in the insulin-stim...

摘要：【摘要】 In mammals, the bladder stores urine without permitting the passage of urine contents into the bloodstream, a function, in part, of the uroepithelial-associated tight junction complex...

摘要：【摘要】 In mouse kidney, the conventional protein kinase C (PKC) isoenzyme is expressed in glomeruli, the cortical collecting duct (intercalated cells only), and medullary collecting duct。 W...

摘要：【摘要】 Localization of protein kinase C (PKC) isoenzymes, I, II,, and was studied employing Western blot analysis and immunohistochemical methods including confocal laser-scanning microscopy...

摘要：【摘要】 Endothelial nitric oxide synthase (eNOS) regulates NaCl absorption by the thick ascending limb of the loop of Henle (THAL)。 We found that augmenting luminal flow induces eNOS activat...

摘要：This study was designed to assess recurrent short-term increases in glucose on markers of renal fibrogenesis。 Human renal cortical fibroblasts were exposed to fluctuating short-term (2 h) increase...

摘要：【摘要】 Adult hypertension may be programmed by the prenatal environment in humans and in experimental animals。 The potential role of the intrarenal renin-angiotensin system (RAS) in prenata...

摘要：【摘要】 The present study examined the functional characteristics of the inward and outward L -[ 14 C]DOPA and L -[ 14 C]leucine transporters in LLC-PK 1 cells。 Uptake was initiated by the a...

摘要：【摘要】 Reflex plasticity between pelvic afferent and pudendal efferent nerve fibers was examined in anesthetized rats。 Brief high-frequency electric stimulation (300 pulses at 100 Hz) of th...

摘要：【摘要】 An uncharacterized murine cDNA clone was identified and, through sequence, phylogenetic, and functional analysis, determined to encode the newest member of the organic anion transport...

摘要：【摘要】 Endothelin-1 (ET-1) acutely inhibits NaCl reabsorption by the thick ascending limb (THAL) by activating the ET B receptor, stimulating endothelial nitric oxide synthase (eNOS), and re...

摘要：【摘要】 A high-salt diet enhances nitric oxide (NO)-induced inhibition of transport in the thick ascending limb (THAL)。 Long exposures to NO inhibit Na-K-ATPase in cultured cells。 We hypoth...

摘要：【摘要】 Hyperhomocysteinemia is a risk factor for cardiovascular disease and occurs frequently in end-stage renal disease (ESRD), but its pathogenesis is poorly understood。 We aimed to evalu...

摘要：Activation of these P2 receptors modulates cellular Ca 2+ signaling and downstream cellular function。 The purpose of this study was to determine whether P2 receptors were present in mIMCD-3 cells,...

摘要：【摘要】 Most of the missense mutations that have been described in the human SLC12A3 gene encoding the thiazide-sensitive Na + -Cl - cotransporter (TSC, NCC, or NCCT), as the cause of Gitelma...

摘要：【摘要】 The effects of adriamycin on the contractile function of cultured mesangial cells were measured by the changes in planar surface area in response to treatment with agonists。 Incubati...

摘要：【摘要】 Kidney transplantation is the preferred and definitive treatment for end-stage renal disease (ESRD), and kidneys from deceased donors are a major source for it。 These kidneys are rou...

摘要：Importantly, the non-zero values of both the slope and y -intercept in the Edelman equation result in several theoretical predictions that can be tested experimentally and have been mathematically ...