摘要:However, we previously showed that the transcription factor, Pax2, suppresses apoptosis in UB cells during kidney development and optimizes branching morphogenesis。 Here, we report that PAX2 direc...
08-07-04摘要:【摘要】 Mesenchymal cells have been isolated from embryos and multiple adult organs where they may differentiate into various connective tissue cell types and provide paracrine support for su...
08-07-04摘要:【摘要】 Sodium-dependent phosphate transport in NHERF-1 -/- proximal tubule cells does not increase when grown in a low phosphate media and is resistant to the normal inhibitory effects of pa...
08-07-04摘要:【摘要】 Collecting ducts are a major site of renal production and action of both prostaglandins and nitric oxide。 Experiments were undertaken to examine whether nitric oxide regulates cycloo...
08-07-04摘要:【摘要】 PKA has traditionally been thought as the binding protein of cAMP for mediating arginine vasopressin (AVP)-regulated osmotic water permeability in kidney collecting duct。 It is now k...
08-07-04摘要:【摘要】 Mitogen-activated protein kinase (MAPK) cascades contain a trio of kinases, MAPK kinase kinase (MKKK) MAPK kinase (MKK) MAPK, that mediate a variety of cellular responses to different...
08-07-04摘要:【摘要】 Endothelin (ET) and nitric oxide (NO) modulate ion transport in the kidney。 In this study, we defined the function of ET receptor subtypes and the NO guanylate cyclase signaling path...
08-07-04摘要:【摘要】 Podocytes are exposed to mechanical forces arising from glomerular capillary pressure and filtration。 However, whether podocytes are sensitive to fluid shear stress is completely unk...
08-07-04摘要:【摘要】 Previously, we showed that oxidant exposure in renal proximal tubular cells (RPTC) induces mitochondrial dysfunction mediated by PKC-。 This study examined the role of ERK1/2 in mitoc...
08-07-04摘要:【摘要】 Pendrin, encoded by Slc26a4, is a Cl - /HCO 3 - exchanger expressed in the apical region of type B and non-A, non-B intercalated cells, which regulates renal NaCl excretion。 Dietary ...
08-07-04摘要:【摘要】 The nephrotoxic metal cadmium at micromolar concentrations induces apoptosis of rat kidney proximal tubule (PT) cells within 3-6 h of exposure。 The underlying cell death pathways rem...
08-07-04摘要:【摘要】 In the rat, urinary concentrating ability develops progressively during the third postnatal (P) week and nearly reaches adult level at weaning ( P21 ) governed by a rise in circulatin...
08-07-04摘要:【摘要】 Previously, we demonstrated gender differences in Na-K-ATPase (NKA) expression and function after renal ischemia-reperfusion (I/R) injury (Sex differences in the alterations of Na +, ...
08-07-04摘要:The kidneys play a critical role in regulating body thiamin homeostasis, by salvaging the vitamin via reabsorption from the glomerular filtrate, but little is known about the mechanism(s) and regul...
08-07-04摘要:【摘要】 Induction of heme oxygenase-1 (HO-1) in renal tubules occurs as an adaptive and beneficial response in acute renal failure (ARF) following ischemia and nephrotoxins。 Using an in vitr...
08-07-04摘要:In states of water depletion, the body releases ADH to decrease water loss by the kidney as well as stimulates water intake by enhancing thirst ( 1 )。 For example, ADH release is stimulated not on...
08-07-04摘要:This gradient is markedly increased in low-salinity habitats。 The Atlantic stingray is a marine elasmobranch that inhabits a remarkable range of environmental salinities。 We hypothesized that the...
08-07-04摘要:【摘要】 Using fura 2-loaded vessels, we tested whether ouabain modulates endothelial cytoplasmic calcium concentration ([Ca 2+ ] CYT ) in rat descending vasa recta (DVR)。 Blockade of voltage...
08-07-04摘要:To determine the functional networks potentially altered by hypoxia, rat renal tubule suspensions were incubated under three conditions of oxygenation ranging from normoxia (lactate uptake) to seve...
08-07-04摘要:【摘要】 Interstitial cystitis (IC) is a chronic bladder inflammatory disease of unknown etiology that shares similarities with Crohn‘s disease and psoriasis。 IC, often regarded as a neuroge...
08-07-04摘要:Using an in vivo rat model of crystalluria induced by hyperoxaluria plus hypercalciuria [ethylene glycol (EG) plus 1,25-dihydroxycholecalciferol (DHC)], we measured glutathione and energy homeostas...
08-07-04摘要:In the present study, we studied the biosynthesis of PGs by highly differentiated human podocytes and in rats。 a nephrosis-inducing agent), steroids (used as primary treatment for nephrotic syndro...
08-07-04摘要:【摘要】 Regulation of ENaC occurs at several levels。 The principal hormonal regulator of ENaC, aldosterone, acts through the mineralocorticoid receptor to modulate ENaC-mediated sodium trans...
08-07-04摘要:【摘要】 The maintenance of apical and basolateral membrane domains with distinct protein and lipid compositions is necessary for the proper function of polarized epithelial cells。 Delivery o...
08-07-04