摘要：【摘要】 The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors exert modulatory effects on a number of cell signaling cascades by preventing the synthesis of various isopren...

摘要：【摘要】 Renal volume regulation is modulated by the action of cyclooxygenases (COX) and the resulting generation of prostanoids。 Epithelial expression of COX isoforms in the cortex directs C...

摘要：【摘要】 Severe ischemia-reperfusion injury (IRI) predisposes to long-term impairment in kidney function both in patients and experimentally through unknown mechanisms。 Given emerging evidenc...

摘要：【摘要】 Renal mass reduction is associated with a compromise in renal excretion, and thus dosages of drugs need to be adjusted to avoid adverse reactions and to ensure their effectiveness。 t...

摘要：【摘要】 Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury in both native kidneys and renal allografts。 However, receptors involved in regulating cytoskeletal repair f...

摘要：【摘要】 The kidney responds to high levels of ANG II, as may occur during malignant hypertension, by increasing sodium and water excretion。 To study whether kidney medullary transporters con...

摘要：【摘要】 Aging is associated with an increase in oxidative stress。 Previously, we have reported that dopamine failed to inhibit proximal tubular Na-K-ATPase and to promote sodium excretion in...

摘要：【摘要】 We have recently proposed severe cardiorenal syndrome (SCRS), in which cardiac and renal failure mutually amplify progressive failure of both organs。 Interactions between inflammatio...

摘要：This phenomenon has been proposed to reflect an increase in delivery to and reabsorption of Na + by the distal nephron, with a resultant increase in the driving force for passive K + efflux across ...

摘要：Nephrogenesis is the process that leads to the formation of nephrons until week 36 of gestation in humans and may be inhibited by many factors like intrauterine growth restriction and premature bir...

摘要：【摘要】 To address the hypothesis that functional changes in tissue transport can be related to structural alterations, we combined mathematical modeling with in vivo experimentation。 After ...

摘要：【摘要】 Acute renal failure (ARF) in septic patients drastically increases the mortality to 50-80%。 Pentoxifylline has several functions including downregulation of TNF- and endothelia-depen...

摘要：【摘要】 It is established that the glomerular filter sieves macromolecules based on their size, shape, and charge。 We therefore investigated the impact of charge on the glomerular permeabili...

摘要：【摘要】 The tubuloglomerular feedback (TGF) system serves to establish an appropriate balance between tubular reabsorption and glomerular filtration rate (GFR)。 A potential modulator of this...

摘要：【摘要】 Transforming growth factor- 1 (TGF- 1 ) is not only an important fibrogenic but also immunomodulatory cytokine in the human kidney。 We have recently demonstrated that TGF- 1 induces ...

摘要：【摘要】 Rats with small bowel resection fed a high-oxalate diet develop extensive deposition of calcium oxalate (CaOx) and calcium phosphate crystals in the kidney after 4 mo。 To explore the...

摘要：【摘要】 Recent studies of the distribution of PKC isoenzymes in the mouse kidney demonstrated that PKC-, - I, and - are expressed in intercalated cells。 The purpose of this study was to iden...

摘要：Efficient absorption depends on coordination of cellular activity across the entire epithelium via cell-to-cell coupling。 In the current study we have utilized a model human collecting duct cell l...

摘要：【摘要】 The -subunit of Na-K-ATPase (FXYD2) and corticosteroid hormone-induced factor (CHIF。 FXYD4) are considered pump regulators in kidney tubules。 The cellular and subcellular locations ...

摘要：【摘要】 The renin-angiotensin system is well known to be involved in the pathophysiological changes in renal function after obstruction of the ureter。 Previously, we demonstrated that bilate...

摘要：It has been proposed that inactivation of the Mre11-Rad50-Nbs1 (MRN) complex due to nuclear exit is responsible for the accumulation of DSBs as cells fail to repair DSBs produced during normal cell...

摘要：【摘要】 Although aldosterone influences a variety of cellular processes through nongenomic mechanisms, the significance of nongenomic pathways for aldosterone-induced regulation of epithelial...