摘要：【摘要】 The novel serine/threonine kinases (with no lysine kinases or WNKs), WNK1 and WNK4, are encoded by the disease genes for Gordon syndrome (PRKWNK1 and PRKWNK4), a rare monogenic syndro...

摘要：【摘要】 This study was performed to evaluate the alterations of glomerular filtration barrier characteristics following acute renal ischemia-reperfusion (I/R)。 Ischemia was induced in anesth...

摘要：【摘要】 Kidney AE1 (kAE1) is a glycoprotein responsible for the electroneutral exchange of chloride for bicarbonate, promoting the reabsorption of bicarbonate into the blood by -intercalated ...

摘要：【摘要】 Idiopathic detrusor underactivity (DU) and detrusor decompensation which develops following partial bladder outlet obstruction (pBOO) are both associated with smooth muscle degenerati...

摘要：【摘要】 In a separate study, we identified PGE 2 as a potent inhibitor of TGF- 1 -induced epithelial-mesenchymal transition (EMT) in cultured Madin-Darby canine kidney (MDCK) cells (Zhang A, ...

摘要：【摘要】 Epithelial-to-mesenchymal transition (EMT) has emerged as a critical event in the pathogenesis of tubulointerstitial fibrosis。 EMT is typically induced by transforming growth factor-...

摘要：Although diabetic nephropathy (DN) in models of type II diabetes has been well characterized, diabetic renal disease in hypoinsulinemic diabetic mice is still incompletely understood。 Here, we cha...

摘要：【摘要】 TG(mRen2)27 (Ren2) transgenic rats overexpress the mouse renin gene, manifest hypertension, and exhibit increased tissue ANG II levels and oxidative stress。 Evidence indicates that e...

摘要：【摘要】 Cisplatin induces renal cell injury and death, resulting in nephrotoxicity that limits its use in cancer therapy。 Using cell culture models, recent work has suggested the involvement...

摘要：【摘要】 Members of the large claudin family of tight junction (TJ) proteins create the differences in paracellular conductance and charge selectivity observed among different epithelia。 We n...

摘要：【摘要】 Transient administration of ANG II causes persistent salt-sensitive hypertension associated with arteriolopathy, interstitial inflammation, and cortical vasoconstriction。 While infil...

摘要：【摘要】 Collecting duct (CD)-derived endothelin-1 (ET-1) inhibits renal Na reabsorption and its deficiency increases blood pressure (BP)。 The role of CD endothelin B (ETB) receptors in media...

摘要：【摘要】 Mineralocorticoids enhance expression and insulin stimulates activity of the serum- and glucocorticoid-inducible kinase SGK1, which activates the renal epithelial Na + channel (ENaC)。...

摘要：【摘要】 Human antigen R (HuR) is a nucleocytoplasmic shuttling protein that binds to and stabilizes mRNAs containing adenine- and uridine-rich elements。 Under normal growth conditions, the b...

摘要：【摘要】 Renal microvascular injury and tubulointerstitial inflammation may provide a potential mechanism for the development of salt-sensitive hypertension。 Therefore, we hypothesized that v...

摘要：【摘要】 Earlier electron microscopy studies demonstrated morphological signs of fluid flow in the juxtaglomerular apparatus (JGA), including fenestrations of the afferent arteriole (AA) endot...

摘要：Failure to do so leads to a large urine output at night, a condition known as nocturnal polyuria, encountered in a large proportion of children with nocturnal enuresis。 The aim of this study was t...

摘要：【摘要】 In the present study, we determined the functional role of 15 positively charged amino acid residues at or within 1 of the predicted 11 transmembrane helixes of the flounder renal sod...

摘要：【摘要】 The product of gene RSC1A1, named RS1, participates in transcriptional and posttranscriptional regulation of the sodium- D -glucose cotransporter SGLT1。 Using coexpression in oocytes...

摘要：【摘要】 The product of gene RSC1A1, named RS1, is involved in transcriptional and posttranscriptional regulation of sodium- D -glucose cotransporter SGLT1, and removal of RS1 in mice led to a...

摘要：【摘要】 We previously demonstrated that arachidonic acid (AA) inhibits epithelial Na channels (ENaC) through the cytochrome P -450 (CYP) epoxygenase-dependent pathway ( 34 )。 In the present ...

摘要：【摘要】 Mechanosensitive ion channels are thought to initiate pressure-induced vasoconstriction, however, the molecular identity of these channels is unknown。 Recent work from our laboratory...

摘要：【摘要】 Aging is associated with alterations in Ca 2+ homeostasis, which predisposes elder people to hyperparathyroidism and osteoporosis。 Intestinal Ca 2+ absorption decreases with aging an...

摘要：【摘要】 In this report, we describe that NF- B is spontaneously activated in isolated, normal glomeruli。 Ex vivo incubation of isolated rat glomeruli triggered expression of a NF- B-dependen...

摘要：【摘要】 Cl - currents were observed under whole cell clamp conditions in cells of the rat cortical collecting duct (CCD), connecting tubule (CNT), and thick ascending limb of Henle‘s loop (T...

摘要：【摘要】 Experiments were performed to test the postulate that exercise training (ExT) improves the blunted renal excretory response to acute volume expansion (VE), in part, by normalizing the...

摘要：【摘要】 The -subunit of Na-K-ATPase is robustly expressed in inner medullary collecting duct (IMCD)3 cells either acutely challenged or adapted to hypertonicity but not under isotonic conditi...

摘要：【摘要】 The adult proximal tubule is a low-resistance epithelium where there are high rates of both active transcellular and passive paracellular NaCl transport。 Claudins are a large family ...

摘要：【摘要】 Calcium oxalate monohydrate (COM) is the primary constituent of the majority of renal stones。 Current concepts of the role of site-specific interactions in crystallization derived fr...

摘要：【摘要】 The interaction of ion channels with the actin-based cytoskeleton in epithelial cells not only maintains the polarized expression of ion channels within specific membrane domains, it ...

摘要：: Renal tubular regulation of urea excretion in man。: Renal tubular excretion of urea in kangaroo rats。: Renal regulation of urea excretion in sheep。: Intrarenal distribution of urea and related...