摘要：【摘要】 In unilateral ureteral obstruction (UUO), the kidney is characterized by increased fibrosis and apoptosis。 Both transforming growth factor- (TGF- ) and ANG II have been implicated, a...

摘要：Here, it is shown that the cytokine TNF- is capable of affecting the fate of macrophages by upregulating the NADase CD38。 CD38 upregulation primes macrophages, such that signals induced by inflamm...

摘要：【摘要】 The vasopressin-aquaporin 2 system plays a key role in urine concentration in dehydration。 In contrast to the upregulation of aquaporin 2, the downregulation of the vasopressin V2 re...

摘要：【摘要】 Obstruction of the urinary tract activates apoptotic pathways in collecting duct cells and leads to loss of renal parenchyma before surgical intervention。 It has been suggested that ...

摘要：【摘要】 The molecular basis for the renal compensation to respiratory acidosis and specifically the role of pendrin in this condition are unclear。 Therefore, we studied the adaptation of the...

摘要：【摘要】 The Na + :HCO 3 - cotransporter NBC1 (SLC4A4, variant A, kidney specific) is located exclusively on the basolateral membrane of epithelial cells, implying that this molecule has acqui...

摘要：【摘要】 Experimental hyperuricemia (HU) results in preglomerular arteriolopathy, cortical vasoconstriction, and glomerular hypertension。 We therefore studied the effect of acute and chronic ...

摘要：SUI is common in women after vaginal delivery or pelvic trauma and may alter the biomechanical properties of the urethra。 Thus we hypothesize that injury due to vaginal distension (VD) decreases u...

摘要：【摘要】 Activation of epithelial sodium channels (ENaC) by aldosterone, insulin, or insulin-like growth factor-1 (IGF-1) in renal epithelial cells (including the Xenopus laevis renal cell lin...

摘要：【摘要】 Parathyroid hormone (PTH), the major systemic calcium-regulating hormone, has been linked to uremic vascular changes。 Considering the possible deleterious action of PTH on vascular s...

摘要：【摘要】 Endothelin-1 (ET-1) is increased in rats on a high-salt (HS) diet and participates in salt-dependent hypertension。 Afferent arterioles (AA) are important for long-term blood pressure...

摘要：【摘要】 WNK kinases [with no lysine (K) kinase] are emerging as regulators of several membrane transport proteins in which WNKs act as molecular switches that coordinate the activity of sever...

摘要：【摘要】 The expression and activity of epithelial Na + channels (ENaC) in the medullary collecting duct of the rat kidney were examined using a combination of whole cell patch-clamp measureme...

摘要：【摘要】 Proteomics combined with cell fractionation was used to identify proteins regulated by high glucose (HG) in human mesangial cells (HMC)。 Further confocal microscopy and Western immun...

摘要：【摘要】 The mathematical model of rat proximal tubule has been extended to include calculation of microvillous torque and to incorporate torque-dependent solute transport in a compliant tubul...

摘要：【摘要】 Renal facilitative urea transporters play a vital role in the urinary concentrating mechanism。 UT-A3 is a phloretin-sensitive urea transporter that in the mouse is expressed on the b...

摘要：【摘要】 We used the patch-clamp technique to study the effect of H 2 O 2 on the apical ROMK-like small-conductance K (SK) channel in the cortical collecting duct (CCD)。 The addition of H 2 O...

摘要：【摘要】 Thiazolidinedione (TZD), a ligand for peroxisome proliferator-activated receptor- (PPAR- ), exerts anti-inflammatory effects independently of the insulin-sensitizing effect。 In the p...

摘要：【摘要】 Patients with end-stage renal disease (ESRD) on hemodialysis have an increased risk of cardiovascular disease (CVD)。 Circulating endothelial progenitor cells (EPC) contribute to vasc...

摘要：【摘要】 Vasoconstriction and increase in the intracellular calcium concentration ([Ca 2+ ] i ) of vascular smooth muscle cells may cause an increase of endothelial cell [Ca 2+ ] i, which, in ...

摘要：【摘要】 The kidney displays highly efficient autoregulation so that under steady-state conditions renal blood flow (RBF) is independent of blood pressure over a wide range of pressure。 The f...