摘要：We applied NAD(P)H oxidase (Nox) inhibitors (apocynin and gp91ds-tat) and revealed this enzyme complex to be crucial for superoxide generation and MKP-1 expression。 Moreover, by performing Nox2/4 ...

摘要：Cells obtained from EGFP transgenic mice were used as a positive control (+) and myocardium obtained from untreated-mice (U) was used as negative control。 Bone marrow cells regenerate infarcted my...

摘要：Bone marrow cells regenerate infarcted myocardium。 Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)。 Bone marrow-derived hematopoietic...

摘要：Impact of the Native NCX in Cardiac Myocytes After Adenoviral Gene TransferIn the present study, adenoviral gene transfer of the wild-type and deletion mutants of NCX was performed in guinea pig ca...

摘要：Adrenergic agonists stimulate cardiac contractility and simultaneously blunt this response by coactivating NO synthase (NOS3) to enhance cGMP synthesis and activate protein kinase G (PKG-1)。 cGMP ...

摘要：Confocal microscopy was used to study the properties of nuclear Ca2+ regulation in adult ventricular myocytes。 Prolonged nuclear Ca2+ release (PNCR) events were identified in both intact and perme...

摘要：From the Editor in Chief, Circulation Research。 As I enter the second half of my editorship of Circulation Research, my reflections pinpoint translation, translation, and translation as the three ...

摘要：7,8 Connexin43 (Cx43) is the major connexin protein in ventricular myocardium, and downregulation of Cx43 (mRNA and protein) has been demonstrated in some experimental HF models and in the failing ...

摘要：From the Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada。Key Words: extracellular matrix , nitric oxide , G-protein , fibronectinTightly regulated remodeling of a...

摘要：AbstractFetal adaptations to impaired maternoplacental nutrient supply include altered regional blood flow。 Fetal Origins of Cardiovascular and Lung Disease。 Fetal venous circulation。 Fetal Mate...

摘要：This Review is part of a thematic series on New Pathways in HDL Metabolism, which includes the following articles: Antiinflammatory Properties of HDL New Insights Into the Regulation of HDL Metabol...

摘要：This Review is part of a thematic series on Angiogenesis, which includes the following articles: Endothelial Progenitor Cells: Characterization and Role in Vascular Biology Bone Marrow–Derived Cel...

摘要：Human Protein C was from Enzyme Research Laboratories。 Cell CultureHuman coronary artery SMCs were from Cambrex (Verviers, Belgium)。 Human smooth muscle cells were isolated from coronary arteries...

摘要：Sarcolemmal Ca2+ entry is a vital step for contraction of cardiomyocytes, but Ca2+ overload is harmful and may trigger arrhythmias and/or apoptosis。 To maintain the amount of Ca2+ entry within an ...

摘要：Remodeling of small arteries is essential in the long-term regulation of blood pressure and blood flow to specific organs or tissues。 Small arteries obtained from rats and pigs both showed inward ...

摘要：8 Cyclin D1 expression resulted in high rates of cardiomyocyte DNA synthesis in adult transgenic hearts, and was thus sufficient to drive cell cycle activity in the adult myocardium。 D-Type Cyclin...

摘要：Myosin Heavy Chain Interacts With FakWe next screened a rat left ventricle cDNA library with yeast two-hybrid system to identify the molecular components that underpin Fak activation pathway。FAK C...