摘要：Abstract Hepatitis C virus (HCV) has been reported to be associated with cardiomyopathy。 Key Words: hepatitis C virus core protein cardiomyopathy Introduction Hepatitis C virus (HCV) is a major et...

摘要：Materials and Methods Transgenic Mice The murine adipocyte FATP1 cDNA with an amino-terminal HA epitope tag was cloned into an -MHC promoter construct kindly provided by J。 Western Blot Analysis f...

摘要：Abstract Calcitonin gene-related peptide (CGRP) is a nonadrenergic/noncholinergic (NANC) peptide with vasodilatative/inotropic action that may benefit the failing heart。 Key Words: calcitonin gene...

摘要：Abstract Fiber organization is important for myocardial excitation and contraction。 Materials and Methods Isolated Coronary Perfused Swine RV Preparations All experiments were performed in accorda...

摘要：Key Words: nitric oxide synthase blood pressure sympathetic nervous system oxidative stress gene transfer Introduction Nitric oxide (NO) in the central nervous system (CNS), including the brain ste...

摘要：Abstract Collagen triple helix repeat containing 1 (Cthrc1) was identified in a screen for differentially expressed sequences in balloon-injured versus normal arteries。

摘要：Abstract Existing evidence led us to hypothesize that increases in p85, a regulatory subunit of PI3-kinase, in presympathetic brain areas contribute to hypertension。 PI3-kinase p85, p110, and p110...

摘要：the Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville。 Regional Heterogeneity in Molecular Control of SMC Marker Gene Expression Expression of most...

摘要：), Harwell, UK the Neural Development Unit (A。 Abstract Loop-tail (Lp) mice develop double outlet right ventricle and aortic arch defects, and the defects are caused by mutations in the Vangl2 gen...

摘要：Instead it inhibited VEGF-induced leukocyte-endothelial cell interactions and the endothelial expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)...

摘要：Abstract Glycogen-Synthase Kinase 3 (GSK3) has been shown to function as a nodal point of converging signaling pathways in endothelial cells to regulate vessel growth, but the signaling mechanisms ...

摘要：2,3 Stem cells are capable of self-renewal, transformation into dedicated progenitor cells, and differentiation into specialized progeny。 Stem and progenitor cell transplantation can have a favora...

摘要：Abstract Seroepidemiological and animal studies, as well as demonstration of viable bacteria in atherosclerotic plaques, have linked Chlamydophila pneumoniae infection to development of chronic vas...

摘要：Vascular adhesion molecule-1 (VCAM-1) is upregulated on the endothelium under inflammatory conditions including atherosclerosis and cardiac allograft rejection5eC8 and appears on the endothelial ce...

摘要：Abstract AMP-activated protein kinase (AMPK) is emerging as an important signaling protein during myocardial ischemia。 AMPK is a heterotrimeric complex containing an catalytic subunit and and regu...

摘要：Materials and Methods Generation of the N-cadherin CKO Mice To generate a targeting vector, a genomic library derived from a 129Sv mouse strain was screened with a probe corresponding to the first ...

摘要：Abstract Endothelial nitric oxide synthase (eNOS) plays an important role in the control of myocardial oxygen consumption (MVO2) by nitric oxide (NO)。 Key Words: endothelial nitric oxide synthase ...

摘要：Abstract Adenosine receptors may be important determinants of intrinsic ischemic tolerance。 Genetically modified mice were used to examine effects of global A1 adenosine receptor (A1AR) knockout (...

摘要：Cystatin CeCdeficient mice (Cyst CeC/eC) were crossbred with apolipoprotein EeCdeficient mice (ApoEeC/eC) to generate cystatin C and apolipoprotein EeCdouble deficient mice (Cyst CeC/eCApoEeC/eC)。...

摘要：the Departments of Physiology (A。H。, D。S。, A。J。, G。K。) and Pharmacology (M。A。C。), New York Medical College, Valhalla the Department of Biochemistry (J。R。F。), University of Texas, Sout...

摘要：Abstract Vascular endothelialeCcadherin (VE-cadherin) plays a key role in angiogenesis and in vascular permeability。 Tyrosine phosphorylation of VE cadherin has been described to accompany the inc...

摘要：Abstract Endothelial production of nitric oxide (NO) is dependent on adequate cellular levels of tetrahydrobiopterin (BH4), an important cofactor for the nitric oxide synthases。 Vascular diseases ...

摘要：Abstract We have shown that the G proteineCcoupled receptor (GPCR) agonists, thrombin and Factor Xa, stimulate smooth muscle cell (SMC) proliferation through transactivation of the EGF receptor (EG...

摘要：In this study, we explored the molecular mechanisms involved in the regulation of the cross-talk between adrenergic and insulin receptors in neonatal rat cardiomyocytes and in transgenic mice with ...

摘要：When released extracellularly, ATP is rapidly degraded to ADP in the circulation by ectonucleotidases。 In this study, we show that ADP acting on P2Y13 receptors on red blood cells serves as a nega...

摘要：Abstract Hyperglycemia increases expression of platelet-derived growth factor (PDGF)- receptor and potentiates chemotaxis to PDGF-BB in human aortic vascular smooth muscle cells (VSMCs) via PI3K an...

摘要：Transient receptor potential channels, particularly of the TRPC (for canonical TRP) and TRPV (for vanilloid TRP) subfamilies, have been demonstrated to be functionally important in regulating Ca2+ ...

摘要：200 eol/L) or correolide (1 eol/L), a selective inhibitor of Kv1 channels, enhanced myogenic contraction of rat mesenteric arteries (RMAs) in response to increases in intraluminal pressure。 Transc...