摘要：The multifocal, chronic, and inflammatory nature of this disease of the cardiovascular system complicates targeted cellular therapy and emphasizes the need to understand the role and interaction of...

摘要：Abstract It becomes increasingly evident that blood platelets do not only exert important functions in hemostasis and thrombus formation but are also involved in atherosclerotic vascular disease。 ...

摘要：Abstract Decreased endothelial NO synthase (eNOS)-derived NO bioavailability and impaired vasomotor control are crucial factors in cardiovascular disease pathogenesis。 We report that resistance ar...

摘要：Myocardial repolarization is a fine-tuned process dependent on the delicate coordination of low strength ionic currents at the end of the action potential。 Common intronic gene variants may influe...

摘要：After an overnight fast, a bolus of highly purified rhCRP was given intravenously at a dose of 1。 After 4 weeks, a time-control study was performed using the CRP-free diluent。 After an initial fa...

摘要：Abstract Vascular calcification is prevalent in aging as well as a number of pathological conditions, and it is now recognized as a strong predictor of cardiovascular events in the general populati...

摘要：12 Interestingly, Atox1 was originally isolated as Antioxidant-1 from yeast, because it protects oxidative damage in yeast。 Superoxide Dismutase Activity Assays SOD activity was assayed by monitor...

摘要：Abstract Nearly a hundred different KCNQ1 mutations have been reported as leading to the cardiac long QT syndrome, characterized by prolonged QT interval, syncopes, and sudden death。 We have previ...

摘要：Results ROCK-Dependent Phosphorylation Depresses Cardiac Myofilament Response to Ca2+ In the first series of experiments, we determined the effect of ROCK-IIeCdependent phosphorylation on Ca2+ acti...

摘要：20 Collagen I and III were differentiated using spectral analysis polarization microscopy on Sirius redeCstained sections: collagen III appears as green fibers, whereas collagen I appears as yellow...

摘要：Cardiac Function In vivo cardiac function was assessed by noninvasive echocardiography, whereas in vitro contractility was examined using the Langendorff perfusion system。 Cardiac catheritization ...

摘要：We used intracoronary injection of a replication-deficient adenoviral construct overexpressing FGF-5 (AdvFGF-5) to improve flow and function in swine with hibernating myocardium。 Two-weeks after A...

摘要：Differentially Expressed Genes Of the total number of transcripts on the Affymetrix RAE230 microarray, 15 442 were expressed in the kidney of SBH/y or SBN/y among any of the four groups studied。 I...

摘要：Development of the human cardiac conduction system。 Development of the cardiac conduction tissue in human embryos using HNK- 1 antigen expression: possible relevance for understanding of abnormal ...

摘要：Inhibition of plaque area and SMC content in apolipoprotein E-deficient mice repopulated with LacZ+ or CXCR4eC/eC BM or lentiviral transfer of an antagonist reveals a crucial involvement of local S...

摘要：Endothelial cells were isolated separately from the aortic and ventricular surfaces of each valve leaflet using a modified Hautchen method。 Aortic-Side Endothelial Gene Expression Is Permissive to...

摘要：Abstract Short QT syndrome (SQTS) leads to an abbreviated QTc interval and predisposes patients to life-threatening arrhythmias。 To date, two forms of the disease have been identified: SQT1, cause...

摘要：Synthetic agonists for the Liver X Receptor (LXR), members of the nuclear hormone receptor superfamily, prevent the development of atherosclerosis by regulating cholesterol homeostasis and suppress...

摘要：10,11 Adenoviral Gene Transfer and Cell Culture HF myocytes were cultured for adenoviral infection in modified M199 medium for 24 to 36 hours after infection。

摘要：This review discusses recent advances establishing a critical role of H2O2 in the development of vascular disease, in particular, atherosclerosis, and mechanisms whereby vascular NAD(P)H oxidaseeCd...

摘要：), Osaka University Graduate School of Medicine, Osaka, Japan Abstract Hepatocyte growth factor (HGF) plays a role in cell protection, antiapoptosis, antifibrosis, and angiogenesis。 Hepatocyte gro...

摘要：12 Glutathione peroxidases (GPxs) are selenocysteine-containing proteins that serve an important role in the cellular defense against oxidant stress by reducing H2O2 and a wide range of organic hyd...

摘要：Materials and Methods Materials Phospho-AMPK (Thr172), pan--AMPK, phospho-p38 (Thr180/Tyr182), and p38 antibodies were from Cell Signaling Technology。 AICAR Promotes VEGF Synthesis and Angiogenesi...

摘要：Abstract NF-B, a transcription factor central to inflammatory regulation during development of atherosclerosis, is activated by soluble mediators and through biomechanical inputs such as flow-media...

摘要：Abstract Hyperphosphorylation of the cardiac Ca2+ release channel (ryanodine receptor, RyR2) by protein kinase A (PKA) at serine-2808 has been proposed to be a key mechanism responsible for cardiac...

摘要：Mechanism(s) underlying such insensitivity to transitions in cytosolic calcium ([Ca2+]i) in microvascular endothelial cells are unknown。 Depletion of stored Ca2+ activates a larger SOC entry respo...

摘要：RT/PCR Analysis of T-Type Channel Gene Expression in PA SMCs and Lung Figure 4A shows a representative gel demonstrating the expression pattern of 1 subunits in cultured human PA SMCs。 Molecular P...

摘要：Pkd2+/eC vascular smooth muscle cells (VSMCs) have an abnormal phenotype and defective intracellular Ca2+ ([Ca2+]i) regulation。 Furthermore, reducing the wild-type VSMC [Ca2+]i by Verapamil or BAP...

摘要：Abstract The CC chemokine Monocyte Chemoattractant Protein (MCP)-1/CCL2 has potent mononuclear cell chemo-attractant properties, modulates fibroblast and endothelial cell phenotype and may play an ...

摘要：Abstract Vascular smooth muscle cells (VSMCs) have a remarkable degree of plasticity and in response to vascular injury, they can change to a dedifferentiated state that can be typically seen in ce...

摘要：Abstract Hop is an unusual homeobox gene expressed in the embryonic and adult heart。 Hop acts downstream of Nkx2eC5 during development, and Nkx2eC5 mutations are associated with cardiac conduction...

摘要：Finally, overactivation of TGF-eCSmad3 pathway is implicated in various fibrotic diseases involving organs such as skin, lung, liver, and kidney。 Disruption of TGF-beta signaling in T cells accele...

摘要：Abstract The novel immunomodulator FTY720 is effective in experimental models of transplantation and autoimmunity, and is currently undergoing Phase III clinical trials for prevention of kidney gra...

摘要：Abstract Myoglobin is an important intracellular O2 binding hemoprotein in heart and skeletal muscle。 Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden de...

摘要：Caveolin-1 functions as a membrane adaptor。 Mice and Vein Graft Procedure Caveolin-1eC/eC mice were provided by M。 Results Mechanical Strain Induces Colocalization of PI3-K With Caveolin-1 and Th...

摘要：Angiotensin II also activates MR-mediated gene transcription in coronary artery VSMCs。 Angiotensin II activation of MR-mediated gene expression is inhibited by both the AT1 receptor blocker losart...

摘要：Abstract Triadin 1 (TRD) is an integral membrane protein that associates with the ryanodine receptor (RyR2), calsequestrin (CASQ2) and junctin to form a macromolecular Ca signaling complex in the c...

摘要：This increase in neuronal activity was associated with increases in NADPH oxidase activity and ROS levels within neurons, the latter evidenced by an increase in ethidium fluorescence。 The increase...

摘要：Endogenous p53 protects VSMCs and stromal cells against apoptosis, a hitherto unknown role in these cells, and also inhibits stromal cell expression of VSMC markers。 p53 Deficiency Has Differentia...