摘要:Assessment of Estrogen Activity The biologic effect of estrogen was assessed by changes in mouse uteri,5 because plasma E2 levels do not represent the biologic effect of estrogen activity in the or...
07-05-18摘要:Abstract Endothelial nitric oxide synthase (eNOS) plays an important role in control of vascular tone and angiogenesis among other functions。 Several studies have emphasized the importance of phos...
07-05-18摘要:Abstract Proliferation of vascular smooth muscle cells (VSMC) is a primary cause of vascular disorders and is associated with major alterations in Ca2+ handling supported by loss of the sarco/endop...
07-05-18摘要:Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction。 Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane r...
07-05-18摘要:Comparative Analyses of Cardiovascular Biomarkers To place the predictive value of baseline ADMA levels into the context of that obtained from measurement of B-type natriuretic peptide, C-reactive ...
07-05-18摘要:Abstract Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regul...
07-05-18摘要:4 Oral L-4F (4F synthesized from L-amino acids) was rapidly degraded by proteolytic enzymes and was not biologically active。7 Oral D-4F (4F synthesized from all D-amino acids) was not degraded and...
07-05-18摘要:Abstract Thyroid hormones have marked cardiovascular effects in vivo。 Key Words: calcium gene expression nuclear receptors vascular smooth muscle thyroid hormone Introduction Thyroid hormone has m...
07-05-18摘要:Abstract Intracellular [Na] is 3 mmol/L higher in heart failure (HF。3), and this can profoundly affect cardiac Ca and contractile function via Na/Ca exchange and Na/H exchange。 Na/K-ATPase is the...
07-05-18摘要:Results Blunted -Adrenergic Stimulation of ICa,L With ISO in HF We first used the ruptured whole-cell patch clamp technique to assess the effect of nonselective -AR stimulation (ISO) on ICa,L in co...
07-05-18摘要:Mitochondrial ROS Formation in Response to Diazoxide, Menadione, and Valinomycin in Cx43 Deficient Cardiomyocytes Diazoxide (200 eol/L) increased ROS formation by 43±10% versus vehicle control in ...
07-05-18摘要:Transgenic supplementation of the mIgf-1 isoform prevents muscle atrophy and activation of the proteasome。 Transgenic Overexpression of mIgf-1 Prevents Activation of the UbiquitineCProteasome Path...
07-05-18摘要:Abstract Reduced arterial compliance and increased pulse pressure are common and major risk factors for cardiovascular disease。 Key Words: apoptosis vascular biology stiffness artery pulse endothe...
07-05-18摘要:Abstract Transgenic mice overexpressing the calcium binding protein, S100A4/Mts1, occasionally develop severe pulmonary vascular obstructive disease。 To understand what underlies this propensity, ...
07-05-18摘要:Abstract Vascular endothelial growth factors (VEGFs) play significant roles in endothelial growth, survival, and function, and their potential use as therapeutic agents to promote the revasculariza...
07-05-18摘要:Adenosine, SCH58261, and wortmannin were purchased from Sigma (St Louis, Mo)。 Results Activation of ERK1/2, JNK, and AKT by Adenosine in CASMC To define the potential cell-signaling pathways relev...
07-05-18摘要:Although Ca2+/calmodulin-dependent protein kinase II (CaMKII) is known to regulate differentiated smooth muscle cell (dSMC) contractility, the importance of targeting in this regulation is not clea...
07-05-18摘要:To evaluate the role of NADPH oxidase in this process, we developed a new model of mouse arteriovenous fistula (AVF) connecting the right common carotid artery (RCCA) with the jugular vein, which d...
07-05-18摘要:Differences Between Organic Nitrates Structurally different organic nitrates exhibit different therapeutic profiles with regard to unwanted reactions and the benefit provided to the patients in spe...
07-05-18摘要:NAD(P)H oxidase is a major source of superoxide in the cardiovascular system。 A membrane-bound gp91phox containing NAD(P)H oxidase in atrial myocytes was the main source of atrial superoxide produ...
07-05-18摘要:Role of MRP1 in Endothelial Thiol Export In other cells, members of the MRP family have been implicated in transport of GSSG。 The Role of MRP1 in Endothelial Cell Survival During Oxidative Stress ...
07-05-18摘要:16 In Vitro Kinase Assay Forty-eight hours after transfection of HEK 293 cells, myocardin constructs were immunoprecipitated in lysis buffer using an anti-myc antibody (clone 9E5, Santa Cruz) as de...
07-05-18摘要:Abstract Gap junctions (GJs) constituted by neighboring cardiac myocytes are essential for gating ions and small molecules to coordinate cardiac contractions。 Key Words: gap junction connexin43 my...
07-05-18摘要:the Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY the TardinieCOlivetti Stem Cell Center (E。 Abstract Cardiac stem cells and early committed cel...
07-05-18摘要:Protein kinase C (PKC) is known to regulate focal adhesion formation。7 Immunoprecipitation of Intracellular Proteins ECs were incubated overnight in serum-free DMEM with 0。 Protein A-G plus agaro...
07-05-18摘要:Abstract Liver X receptors (LXRs) are nuclear receptors that regulate macrophage cholesterol efflux by inducing ATP-binding cassette transporter A1 (ABCA1) and ABCG1/ABCG4 gene expression。 Results...
07-05-18摘要:Loss of pentameric symmetry of C-reactive protein is associated with delayed apoptosis of human neutrophils。
07-05-18摘要:Intermittent hypoxia increases insulin resistance in genetically obese mice。 Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human macrophages。
07-05-18摘要:Abstract Urotensin II (UII), which acts on the G protein-coupled urotensin (UT) receptor, elicits long-lasting vasoconstriction。 Key Words: urotensin II vascular tone urotensin receptor recycling ...
07-05-18摘要:Complement forms a bridge between innate and acquired immunity。 Complement activation has been implicated in the pathogenesis of numerous proteinuric renal diseases including glomerulonephritis, t...
07-05-18摘要:Effect of Insulin Resistance and Diabetes on Metabolic Parameters and Neointimal Response Zucker fatty rats were obese, with mild hyperglycemia and severe insulin resistance as evidenced by very hi...
07-05-18摘要:Abstract Interaction between aldosterone (Aldo) and angiotensin II (Ang II) in the cardiovascular system has been highlighted。 Here, we examined the cross-talk of growth-promoting signaling betwee...
07-05-18摘要:Abstract Endothelial protein kinase C (PKC) signaling was investigated in different regions of normal porcine aorta。 Endothelial lysates were isolated from the inner curvature of the aortic arch (...
07-05-18摘要:The Department of Biomedical Engineering (K。L。, G。M。S。, M。S。P。), Case Western Reserve University, Cleveland Departments of Cardiovascular Medicine and Cell Biology (K。L。, F。F。, M。S。P。...
07-05-18摘要:However, LV myocytes isolated from LVH dogs exhibited impaired contraction at baseline and in response to Ca2+。 There was no change in L-type Ca2+ channel current (ICa) density but the ability of ...
07-05-18摘要:Results Sudden Death in Cardiac-Restricted N-Cadherin Mutant Mice To overcome the requirement for N-cadherineCmediated adhesion during heart development, we used a N-cadherin conditional knockout m...
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