摘要：Results Resting Membrane Potential and Dye Coupling Electrophysiological data were obtained in arterioles with a diameter between 40 and 60 e, ie, second-order branching vessels in 41 animals。 Myo...

摘要：Recent studies indicate that dysregulation of mitogen-activated protein kinase (MAPK) signaling might play a major role in the pathogenesis of congenital valvular malformations, and, in this study,...

摘要：Western Blotting Regional expression of G proteins (25 e/lane) and G-protein receptor kinase (GRK) (40 e/lane) was determined on membrane preparations as previously described。 Radioligand Binding ...

摘要：Abstract Transplantation of blood-derived circulating progenitor cells (CPC) has been shown to improve myocardial regeneration after myocardial infarction。3eC10 In the TOPCARE-AMI (Transplantation...

摘要：Abstract Endothelial dysfunction in vascular disease states is associated with reduced NO bioactivity and increased superoxide (O2·eC) production。 Endothelial BH4 availability is a pivotal regula...

摘要：This study examined the role of AMPK in the activation of the p38 mitogen-activated protein kinase (MAPK)。 In isolated heart muscles, the AMPK activator 5-aminoimidazole-4-carboxy-amide-1--D-ribof...

摘要：LA Has a Protective Role in Hemodynamic and Survival Studies The preservation of hemodynamics in LA-treated rats was associated with increased mean arterial pressure (87±2。 Lipoic acid reduces is...

摘要：High GlucoseeCInduced SphK Activity Mediates EC Activation Given the effect of high glucose on SphK activity in EC, we sought to determine the functional consequences of SphK activation induced by ...

摘要：Transforming growth factor-1 (TGF-1) irreversibly converts fibroblasts into pathological myofibroblasts, which express smooth muscle -actin (SM -actin) de novo and produce extracellular matrix。 We...

摘要：Abstract TRPV4 is a broadly expressed Ca2+-permeable cation channel in the vanilloid subfamily of transient receptor potential channels。 To evaluate the role of TRPV4 and its modulation by the CYP...

摘要：), National Institute of Environmental Health Sciences, Research Triangle Park, NC Departments of Physiology and Medicine, The Cardiovascular Research Laboratories (C。 Abstract During ischemia and...

摘要：Abstract Apolipoprotein E (apoE) is synthesized in the liver and in macrophages, and it has antiatherogenic properties that are mediated, at least in part, through the regulation of plasma choleste...

摘要：Smad4 is the central intracellular mediator of TGF- signaling。 To investigate the function of Smad4 in heart development further, we generated a strain of cardiomyocyte-specific Smad4 knockout mic...

摘要：Cardiac NE spillover is the net result of NE release from nerve terminals and clearance of synaptic NE mainly caused by reuptake via the uptake carriers。18 Norepinephrine Uptake Measurements in Is...

摘要：the Department of Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Mass。 Abstract Heparin has growth inhibitory effects on pulmonary arte...

摘要：Effect of the Aldosterone Receptor Blockade by Eplerenone on Cellular and Cardiac ACE and ACE2 Activities in Mice To determine whether the effect observed with spironolactone on macrophage ACE2 rel...

摘要：The nonreceptor tyrosine kinase, proto-oncogene cAbl is a substrate of Src and is a major mediator for ROS-dependent tyrosine phosphorylation of Cav1。 We thus hypothesized that cAbl is important f...

摘要：Adenosine monophosphate-activated protein kinase (AMPK) plays a key role in the regulation of energy homeostasis and monitors cellular energy charge, acting as a “metabolic master switch“ to regu...

摘要：the Johns Hopkins Singapore and National Heart Center, Vascular Biology Program (M。 Abstract Vascular endothelial growth factor (VEGF) has been implicated in angiogenesis associated with coronary ...

摘要：Abstract Carbon monoxide (CO) is an endogenous paracrine and autocrine gaseous messenger that regulates physiological functions in a wide variety of tissues。10eC12 Carbon monoxide is a physiologic...

摘要：Abstract To test the hypothesis that apolipoprotein A-I (apoA-I) functions specifically to inhibit atherosclerosis independent of the level of high-density lipoprotein cholesterol (HDL-C) by promot...

摘要：We tested the hypothesis that NADPH oxidase-derived superoxide anion (O2·eC) in the RVLM mediates Ang IIeCinduced pressor response via activation of mitogen-activated protein kinase (MAPK) signali...