摘要:Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure。 Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortal...
07-05-18摘要:Endothelin-1 ELISA RPAEC were plated in 6-well plates and allowed to grow overnight。 Cells were then treated with CDCA or GW4064 in conditioned medium for 24 hours, and ET-1 in the supernatant was...
07-05-18摘要:Protection by H11K Requires the Phosphatidylinositol 3-Kinase Pathway We showed previously that the TG mouse is characterized by an increased phosphorylation of Akt,2 which could be reproduced acut...
07-05-18摘要:Here we report that TRPM7, which is both an ion channel and a functional kinase, is translocated within cells in response to laminar flow。 After exposure of cells to physiological values of lamina...
07-05-18摘要:Materials and Methods Cell Culture Bovine aortic endothelial cells (BAECs) were passaged from primary cultures and used for experiments during passages 2 to 6。 Cells were then lysed in ice-cold bu...
07-05-18摘要:Abstract Here we identified growth-differentiation factor 15 (GDF15) (also known as MIC-1), a secreted member of the transforming growth factor (TGF)- superfamily, as a novel antihypertrophic regul...
07-05-18摘要:2,3 Transforming growth factor-s (TGF-s) constitute a superfamily of cytokines that exert prominent functions in adult tissue homeostasis and adaptation by regulating cell survival, proliferation, ...
07-05-18摘要:Abstract Statins are inhibitors of 3-hydroxy-3-methylglutaryleCcoenzyme A (HMG-CoA) reductase used in the prevention of cardiovascular disease (CVD)。 Key Words: inflammation macrophages neutrophil...
07-05-18摘要:Key Words: versican antisense elastogenesis vascular injury remodeling Introduction Versican, a chondroitin sulfate (CS) proteoglycan, is a major determinant for the structural and physiological pr...
07-05-18摘要:Abstract Lipoma preferred partner (LPP) has been identified as a protein highly expressed in smooth muscle (SM) tissues。 The aim of the present study was to determine mechanisms that regulate LPP ...
07-05-18摘要:Cortactin is a substrate of Src tyrosine kinases and a regulator of cytoskeletal dynamics。 Cortactin is an F-actin binding protein and an important substrate of Src tyrosine kinases。5 Cortactin c...
07-05-18摘要:Control, Isoproterenol, and NOS Inhibitor Treatment Hearts from male (n=9, wild type [WT]。24 Preparation of Membrane Fractions from Mouse Hearts All preparative procedures were performed in the da...
07-05-18摘要:Differences in hemodynamic environments between veins and arteries may play an important role in the development of atherosclerosis but cannot fully explain the differences in predisposition to ath...
07-05-18摘要:Rotational movement was confirmed by Di-I injection experiments with cultured embryos。 Rotation of OFT Myocardium The expression profile of the 96-16 transgene between E9。 Defects in OFT Rotation...
07-05-18摘要:Vein Graft Procedure and Treatment For vein grafts, animals of the same genotype as donors and recipients were used。22 Vein grafts were harvested by cutting the implanted segments from the native ...
07-05-18摘要:MEKs Are Involved in Basal and Protein Kinase CeCRegulated KChIP2 mRNA Expression To identify signaling mechanisms underlying the PE-induced decrease in KChIP2 mRNA expression, we used various inhi...
07-05-18摘要:Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells。 Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells。 Bon...
07-05-18摘要:We examined the effect of diabetes mellitus on oxidative stress and Rac-1 activation, a small G-protein involved in the activation of NADPH oxidase。 Our results show that oxidative stress in vesse...
07-05-18摘要:Determination of PDE2 Activity in Lysates From Unstimulated and NE-Treated Myocytes Unlike other PDEs expressed in heart cells (eg, PDE321 and PDE422), no stable activation of PDE2 activity has bee...
07-05-18摘要:Calcium, calmodulin, and calcium/calmodulin kinase II: from heartbeat to heartbeat and beyond。 Calcium/calmodulin-dependent protein kinase II associates with the ryanodine receptor complex and reg...
07-05-18摘要:Mouse Model of Angiogenesis GPx-1 KO and WT mice were subjected to unilateral hindlimb surgery under anesthesia with sodium pentobarbital (50 mg/kg intraperitoneally)。 Results Impaired Ischemia-In...
07-05-18摘要:Abstract Adrenomedullin (AM) levels are elevated in cardiovascular disease, but little is known of the role of specific receptor components。 Key Words: adrenomedullin blood pressure CGRP receptor-...
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