摘要:Exercise prevented fibrosis, myocyte disarray, and induction of “hypertrophic“ markers including NFAT activity when initiated before established HCM pathology。 Exercise in HCM mice also favorabl...
07-05-18摘要:Previously, we demonstrated that major histocompatibility class II (MHC II) transactivator (CIITA) in a complex with regulatory factor for X box 5 (RFX5) is a crucial protein mediating interferon (...
07-05-18摘要:Neurogenic Mechanisms Contribute to Hypertension in Kcc3eC/eC Mice To characterize the arterial hypertension of Kcc3eC/eC mice in vivo, we investigated the effects of vasoactive substances on mean ...
07-05-18摘要:Here we reveal the importance to this process of TRPC1, a homolog of Drosophila transient receptor potential。 Using 2 different in vivo models of vascular injury in rodents we show hyperplasic smo...
07-05-18摘要:8 Apolipoprotein A (ApoA)-I is the major protein component of HDL。 Homocysteine Treatment of HepG2 Cells At 80% confluence, the medium was replaced with DMEM-F12 supplemented with 0, 1, 5, or 10 m...
07-05-18摘要:Endothelial cells present CXC receptor 3 (CXCR3) for chemokines expressed late in wound regeneration。 To understand the physiological role CXCR3 plays in regulating endothelial function, we analyz...
07-05-18摘要:Abstract Elevated plasma levels of plasminogen activator inhibitor type I (PAI-1), a significant risk factor of ischemic heart disease, are associated with insulin resistance in which insulin and t...
07-05-18摘要:the Department of Medical Biochemistry and Microbiology (A。L。, K。R。), University of Uppsala, Sweden the Department of Biomedicine (A。B。, T。N。, R。K。R。), Division of Physiology, University...
07-05-18摘要:Prostaglandins, butaprost, AH6809, and anti-EP2 antibody were purchased from Cayman Chemical Inc。 Results OxPAPC Activates Prostaglandin E2 Receptor EP2 Three main strategies were used to screen t...
07-05-18摘要:Quantitative traits, although strongly associated with PFO (P0。
07-05-18摘要:The strength and duration of G protein signaling is attenuated by regulator of G protein signaling (RGS) proteins acting as GTPase-activating proteins for G subunits。 however, little is known abou...
07-05-18摘要:Subcellular Localization of Neuronal Na Channels in Ventricular Myocytes We determined the fraction of TTX-sensitive and TTX-resistant INa by fitting with double Hill curves。 Functional Role of Ne...
07-05-18摘要:On binding to Robo receptors, Slit2 repels developing axons and inhibits leukocyte chemotaxis。 Slit2 is cleaved into Slit2-N, a protein tightly binding to cell membranes, and Slit2-C, a diffusible...
07-05-18摘要:Adenylyl Cyclase Activity Assay Assays were performed using a 1-mL solution of 0。 Adenylyl cyclase and cAMP regulation of the endothelial barrier。 Soluble adenylyl cyclase as an evolutionarily co...
07-05-18摘要:Abstract In the vasculature, ATP-sensitive potassium channels (KATP) channels regulate vascular tone。 Mice with targeted gene disruptions of KATP subunits expressed in vascular smooth muscle devel...
07-05-18摘要:Histological Analysis of Engrafted EGFP+ Cells Hearts from engrafted mice were excised and processed for paraffin sectioning as described previously。 Fluorescence In Situ Hybridization Analysis of...
07-05-18摘要:Endothelial dysfunction is also thought to be a factor that contributes to the increased incidence of restenosis in diabetes。 Contribution of EPCs to Endothelial Recovery Is Reduced in Diabetes As...
07-05-18摘要:), Department of Internal Medicine Institute for Advanced Cardiac Therapeutics (S。), Tokyo Women’s Medical University Department of Regenerative Medicine and Advanced Cardiac Therapeutics (K。 Ti...
07-05-18摘要:Role of eNOS Activation in Ox-PAPCeCInduced IL-8 Synthesis To examine the role of eNOS activation in the induction of IL-8 expression by Ox-PAPC, we used the NOS chemical inhibitor L-NAME and its i...
07-05-18摘要:Here, we demonstrate that PDE1A, a Ca2+-calmodulineCstimulated PDE preferentially hydrolyzing cGMP, is predominantly cytoplasmic in medial “contractile“ VSMCs but is nuclear in neointimal “synth...
07-05-18摘要:Growth Factors。
07-05-18摘要:“13,14 Endothelial activation was first described in endothelial cells exposed to endotoxin or cytokines such as IL-1, tumor necrosis factor (TNF)-, or IL-6。 Cell Cultures Porcine aortic endothel...
07-05-18摘要:Results Oxidative Stress Induces Secretion of Cyclophilin A From Vascular Smooth Muscle Cells We have previously demonstrated that LY83583, an intracellular superoxide generator, induces secretion ...
07-05-18摘要:Hydrolysis of HDL Is a Distinct Lipolytic Mechanism for PPAR Activation The unique biologic role of EL among lipases establishes the importance of these observations for EL/HDL-mediated PPAR activa...
07-05-18摘要:Cell Culture Pulmonary arteries (500-e internal diameter) were microdissected from wild-type and BMPR2+/eC mice。 Pulmonary artery smooth muscle cells (PASMCs) were explant derived and grown in 20%...
07-05-18摘要:Abstract The stress-responsive serum- and glucocorticoid-inducible kinase Sgk-1 is involved in osmoregulation and cell survival and may contribute to fibrosis and hypertension。 However, the functi...
07-05-18摘要:Traditional deletion of Gata4 caused embryonic lethality associated with endoderm defects and cardiac malformations, precluding an analysis of the role of GATA4 in the adult myocardium。 To address...
07-05-18摘要:11 One of these genes, which we named embryonic growth-associated protein (EGAP), is expressed in a variety of tissues in the developing rat embryo but restricted in expression in the adult, remain...
07-05-18摘要:Results Phenotype of Cultured Fibroblasts Cardiac fibroblasts in cell culture tend to undergo a phenotype switch to myofibroblasts。 Modification of Impulse Conduction by a Coat of Myofibroblasts T...
07-05-18摘要:Abstract Prostaglandin E2 exerts an antiinflammatory action by ligation of the heptahelical receptor EP4 in human macrophages。 Prostaglandin-E2 is a potent inhibitor of human interleukin 12 produc...
07-05-18摘要:Higher levels of basal PKA inhibition abolish LCRs and spontaneous beating ceases。 Basal PKA-dependent phosphorylation is obligatory for both, the occurrence of spontaneous basal LCR and spontaneo...
07-05-18摘要:Abstract The contribution of sodium-dependent bicarbonate transport to intracellular pH (pHi) regulation in vascular smooth muscle cells is controversial, partly because the molecular identity of t...
07-05-18摘要:10 Interleukin (IL)-12, a heterodimeric cytokine released by activated macrophages and DC, is abundantly produced in plaque tissues。 T-Cell Lines and T-Cell Clones Tissue fragments were immediatel...
07-05-18摘要:Abstract Circadian rhythms are regulated by a set of clock genes that form transcriptional feedback loops and generate circadian oscillation with a 24-hour cycle。 Circadian expression of clock gen...
07-05-18