摘要：AbstractIt has become axiomatic that basic science faculty and research programs at medical schools must support themselves。 The days when excess clinical revenue was used to support basic researc...

摘要：eduIn his book Bullets and bacilli: the Spanish-American War and military medicine, Vincent Cirillo presents a highly readable account of the medical history of the Spanish-American War, a war that...

摘要：ukPlague is caused by Yersinia pestis, perhaps the most notorious of all infectious agents that nowadays can be considered a “down, but not out“ pathogen。 Globally, the WHO estimates that there ...

摘要：AbstractType 1 diabetes is the result of an autoimmune attack against the insulin-producing 。 cells of the endocrine pancreas。 Current treatment for patients with type 1 diabetes typically involv...

摘要：AbstractAdenosine is a ubiquitous biological mediator with the capacity to produce both pro- and anti-inflammatory effects in tissues。 Proinflammatory and bronchoconstrictive actions of adenosine ...

摘要：AbstractInsulin secretion is critically dependent on the proper function of a complex molecular network。3–/–) and PKC-knockout (PKC–/–) mouse models now suggest that these 2 players, the Cav2。...

摘要：In this study we examined the contribution of A1 adenosine receptor (A1AR) signaling to the pulmonary inflammation and injury seen in adenosine deaminase–deficient (ADA-deficient) mice, which exhi...

摘要：AbstractPregnane X receptor (PXR) plays an important role in detoxifying xenobiotics and drugs。 provide convincing evidence that PXR can also induce vitamin D deficiency and bone disease because o...

摘要：AbstractProgression of hepatic fibrosis requires sustained inflammation leading to activation of stellate cells into a fibrogenic and proliferative cell type, whereas regression is associated with ...

摘要：AbstractStromal cell–derived factor–1 (SDF-1) is a chemokine with unique functions, including a role in the trafficking of primitive blood precursor cells。 A better understanding at a molecular ...

摘要：report the identification of a novel oncogene in patients affected by radiation-associated thyroid papillary carcinomas。 This oncogene derives from a paracentric inversion of the long arm of chrom...

摘要：Parkinson’s Institute, Sunnyvale, California, USA。AbstractNeurotransplantation as a treatment for Parkinson disease reached the stage of human trials over 15 years ago, but the field, which is st...

摘要：AbstractFor several decades, intravenous Ig has been used as treatment for a variety of immune-related diseases, including immune thrombocytopenic purpura (ITP), autoimmune neuropathies, systemic l...

摘要：We investigated macrophage function mechanistically in a reversible model of liver injury in which the injury and recovery phases are distinct。 Carbon tetrachloride--–induced liver fibrosis revea...

摘要：1Department of Medicine (Gastroenterology),2Department of Surgery (Transplantation and Gastrointestinal), and3Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA。...

摘要：AbstractThe introduction of highly active antiretroviral therapy (HAART) has significantly decreased morbidity and mortality among patients infected with HIV-1。 However, HIV-1 can acquire resistan...

摘要：AbstractDiabetic retinopathy is the leading cause of blindness in working-age adults。 It is caused by oxygen starvation in the retina inducing aberrant formation of blood vessels that destroy reti...

摘要：In thyroid papillary carcinomas, mutations of genes coding for effectors along the MAPK pathway are central for transformation。 BRAF point mutation is most common in sporadic tumors。 We report he...

摘要：AbstractParkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic (DA) neurons。 ES cells are currently the most promising donor cell source for cell-rep...

摘要：AbstractWe used bioluminescence imaging to reveal patterns of metastasis formation by human breast cancer cells in immunodeficient mice。 Individual cells from a population established in culture f...

摘要：AbstractThe angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized。 Here we report that PDGF-CC mob...

摘要：AbstractThe persistence of HIV-1 in virally suppressed infected individuals on highly active antiretroviral therapy (HAART) remains a major therapeutic problem。 Immune activation therapy using IL-...

摘要：AbstractAltered regulation of insulin secretion by glucose is characteristic of individuals with type 2 diabetes mellitus, although the mechanisms that underlie this change remain unclear。 We have...

摘要：AbstractConcerted activation of different voltage-gated Ca2+ channel isoforms may determine the kinetics of insulin release from pancreatic islets。 A 20% reduction in glucose-evoked insulin secret...

摘要：AbstractIntravenous Ig (IVIg) mediates protection from the effects of immune thrombocytopenic purpura (ITP) as well as numerous other autoimmune states。 however, the active antibodies within IVIg ...

摘要：AbstractLipoprotein lipase (LPL) is thought to be the only enzyme responsible for the catabolism of triglycerides (TGs) associated with TG-rich lipoproteins in adipose tissue (AT)。 However, LPL de...

摘要：AbstractThe chemokine stromal cell–derived factor–1 (SDF-1) and its receptor, CXCR4, play a major role in migration, retention, and development of hematopoietic progenitors in the bone marrow。 W...

摘要：Here we show that these drugs lead to the upregulation of 25-hydroxyvitamin D3-24-hydroxylase (CYP24) gene expression through the activation of the nuclear receptor pregnane X receptor (PXR。 CYP24...

摘要：AbstractOligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker in MS, the most common demyelinating disease of the CNS。 We have attempted to identify the B ce...

摘要：Original citation: J。 Clin。 Invest。 114:1640–1649(2004)。 doi:10。1172/JCI200422325Citation for this erratum: J。 Clin。 Invest。 115:195 (2005)。 doi:10。1172/JCI200522325E1During the preparat...