摘要:AbstractThe recent uproar over comments about women in science made by Harvard University President Dr。 Summers to make statements about the “different availability of aptitude at the high end“ ...
07-05-11摘要:Early in the last decade, great strides were made toward eliminating malaria through the use of pest control and extermination of mosquitoes, which are responsible for transmitting the infectious P...
07-05-11摘要:The average life expectancy in the US has hit a record high of 77。
07-05-11摘要:President Bush’s proposed 2006 budget for the NIH will remain virtually unchanged from the current fiscal year。 After the budget doubled in the 5 years between 1998 and 2003, the current financia...
07-05-11摘要:Elizabeth Nabel, formerly the scientific director of clinical research in the NHLBI intramural program and a board-certified cardiologist, is now at its helm。In her new role, Nabel manages nearly ...
07-05-11摘要:eduAside from the Bible, Darwin’s The origin of species is arguably the most important book ever written。“ Almost a century and a half later, emotions surrounding the book and its implications s...
07-05-11摘要:netThe interdisciplinary science of genetic toxicology emerged in the 1960s as a result of a unique cross-fertilization of genetics and radiation biology。 The talented, committed scientists who in...
07-05-11摘要:AbstractPerhaps because I am a veteran of the “good old days“ (they were really quite bad), young physicians who hope to become clinical investigators often ask me how they might establish their ...
07-05-11摘要:AbstractCutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally derived, skin-invasive T cells。 Mycosis fungoides (MF) and Sézary syndrome ...
07-05-11摘要:AbstractMelanoma is a cancer of the neural crest–derived cells that provide pigmentation to skin and other tissues。 This review focuses on recent insights into melanoma genetics and new therapeut...
07-05-11摘要:AbstractKnowledge of the pathophysiology of immunobullous diseases has been advanced by the demonstration that passive transfer of antibodies against skin autoantigens can induce blisters in experi...
07-05-11摘要:It is therefore not surprising that long-lived mammals have highly conserved, complex pathways that regulate cell death。 Studies of the apoptotic pathways in the past decade have led to the realiz...
07-05-11摘要:AbstractRare mutations in MEF2A have been proposed as a cause of coronary artery disease (CAD) and myocardial infarction (MI)。 In this issue of the JCI, Pennacchio and colleagues report sequencing...
07-05-11摘要:AbstractIn this issue of the JCI, Niedermaier and colleagues demonstrate that a chromosomal inversion in mice results in dysregulation of Sonic hedgehog (Shh), such that Shh is ectopically expresse...
07-05-11摘要:AbstractIn systemic lupus erythematosus (SLE), IL-2 production by T lymphocytes in vitro is impaired。 Deficient IL-2 production may be an outcome of a primary SLE T cell disorder that is due to im...
07-05-11摘要:AbstractBlood pressure abnormalities are thought to originate from intrinsic changes in the kidney, a concept that has been largely unchallenged for more than 4 decades。See the related article beg...
07-05-11摘要:AbstractThe hypothalamic-pituitary-adrenal axis (a major component of the stress system) and the immune system contribute to the maintenance of homeostasis at rest and during stress。 demonstrate t...
07-05-11摘要:AbstractThe inhibitor of NF-B (I-B) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-B essential modulator (NEMO), and is involved in the activation of NF-B by various stimuli。 IKK2...
07-05-11摘要:AbstractEpidermolysis bullosa acquisita (EBA) is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies specific to type VII collagen, a major constituent of...
07-05-11摘要:Homozygous mice are characterized by multiple defects strongly resembling those resulting from Sonic hedgehog (Shh) inactivation。 We mapped Dsh to chromosome 5 in a region containing Shh and were ...
07-05-11摘要:AbstractPemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1。 Using...
07-05-11摘要:AbstractAutosomal dominant polycystic kidney disease (ADPKD) is the most common human monogenic genetic disorder and is characterized by progressive bilateral renal cysts and the development of ren...
07-05-11摘要:We established the age-dependent incidence, time course, and duration of thymic enlargement in adults and demonstrated that these changes were correlated with peripheral recovery of naive CD45RA+CD...
07-05-11摘要:AbstractInsulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis。 cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiom...
07-05-11摘要:AbstractCentral control of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in peripheral en...
07-05-11摘要:AbstractThe mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive。 ...
07-05-11摘要:AbstractLipid rafts are cholesterol- and sphingolipid-enriched microdomains in cell membranes that regulate phosphorylation cascades originating from membrane-bound proteins。 In this study, we tes...
07-05-11摘要:AbstractThe binding of HDL to scavenger receptor–BI (SR-BI) mediates cholesterol movement。 Phosphatidylcholine-loaded HDL caused greater stimulation than native HDL, and blocking antibody against...
07-05-11摘要:AbstractThe mainstay in the management of invasive bladder cancer continues to be radical cystectomy。 With regard to improvement of quality of life, however, therapies that preserve the bladder ar...
07-05-11摘要:AbstractPlatelet activation is a hallmark of severe preeclampsia, and platelet PGH synthase 1–derived (PGHS1-derived) thromboxane A2 (TxA2) has been implicated in its pathogenesis。 However, genet...
07-05-11摘要:AbstractSystemic lupus erythematosus (SLE) T cells express high levels of cAMP response element modulator (CREM) that binds to the IL-2 promoter and represses the transcription of the IL-2 gene。 T...
07-05-11摘要:AbstractMutations in the gene encoding hepatocyte nuclear factor-4 (HNF-4) result in maturity-onset diabetes of the young (MODY)。 To determine the contribution of HNF-4 to the maintenance of gluco...
07-05-11摘要:AbstractMutations in MEF2A have been implicated in an autosomal dominant form of coronary artery disease (adCAD1)。 In this study we sought to determine whether severe mutations in MEF2A might also...
07-05-11摘要:AbstractIkaros transcription factors are essential regulators of lymphopoiesis and the development of the immune system。 We now show that Ikaros is expressed in hormone-producing pituitary cortico...
07-05-11摘要:AbstractEffective therapies for the treatment of obesity, a key element of metabolic syndrome, are urgently needed but currently lacking。 In the current study, we tested the efficacy of pharmacolo...
07-05-11摘要:We hypothesized that Bfl-1/A1, an antiapoptotic Bcl-2 protein, is a critical regulator of HALI and a mediator of IL-11–induced cytoprotection。 In WT mice, 100% O2 caused TUNEL+ cell death, induct...
07-05-11摘要:Control of sodium excretion by the kidney has been suggested to be the critical mechanism for blood pressure regulation by the renin-angiotensin system (RAS)。 However, since AT1 receptors are ubiq...
07-05-11摘要:Our analysis of 14 XLP patients revealed normal B cell development but a marked reduction in the number of memory B cells。 The few memory cells detected were IgM+, revealing deficient isotype swit...
07-05-11摘要:AbstractExtracellular proteolysis by the plasminogen/plasmin (Plg/plasmin) system and MMPs is required for tissue injury in autoimmune and inflammatory diseases。 We demonstrate that a Plg cascade ...
07-05-11摘要:In this study, we demonstrate, for the first time to our knowledge, that overexpression of OPN in synovial T cells is associated with local inflammatory milieu and that OPN acts as an important med...
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