摘要：Bush and Senate majority leader Bill Frist have recently publicly advocated teaching intelligent design in science classes。In an interview with Texan reporters, Bush supported the notion of giving...

摘要：Richard Schlegel is a pioneer in human papillomavirus (HPV) research。 Schlegel, chairman of the Department of Pathology at Georgetown University Medical Center, has long studied the protein shell ...

摘要：Owing in large part to their daily exchange policies, these public databases for DNA and RNA sequences have reached 100 gigabases of information。These 100,000,000,000 bases of genetic code, collec...

摘要：Did Leonard Hayflick hit the nail of senescence on the head when he proposed that our cells can divide a limited number of times, after which they die。m thinks that the substantial effects of mani...

摘要：This is the setting of Testosterone dreams: rejuvenation, aphrodisia, doping, John Hoberman’s book about the marketing of estrogen and testosterone from their first medical use to the present, inc...

摘要：itThe possibility that genius, special talents, and skills can be explained by an analysis of brain structure has fascinated people for centuries。 This exploration is the subject of the book Postc...

摘要：AbstractSince the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood a...

摘要：AbstractAbout 5% of American women and 12% of men will develop a kidney stone at some time in their life, and prevalence has been rising in both sexes。 Approximately 80% of stones are composed of ...

摘要：AbstractThis series of Reviews on cell death explores the creation of new therapies for correcting excessive or deficient cell death in human disease。 Signal transduction pathways controlling cell...

摘要：AbstractThe Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism。 The ...

摘要：AbstractIB kinase/NF-B (IKK/NF-B) signaling pathways play critical roles in a variety of physiological and pathological processes。 One function of NF-B is promotion of cell survival through induct...

摘要：AbstractInduction of heat shock proteins (Hsps) following cellular damage can prevent apoptosis induced by both the intrinsic and the extrinsic pathways。 Hsps promote cell survival by preventing M...

摘要：AbstractCell death by apoptosis or necrosis is often important in the etiology and treatment of disease。 Since mitochondria play important roles in cell death pathways, these organelles are potent...

摘要：AbstractThe commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins。 The physiological result of a decision by these ...

摘要：AbstractDisturbances in the normal functions of the ER lead to an evolutionarily conserved cell stress response, the unfolded protein response, which is aimed initially at compensating for damage b...

摘要：AbstractCaspases, a family of cysteine proteases, play a central role in apoptosis。 We also describe the current knowledge of how interference with caspase signaling can be used to pharmacological...

摘要：use genomic sequence data to compare the proteins produced by yeasts with and without complex I in order to generate a list of proteins whose human orthologs might serve as complex I assembly prote...

摘要：AbstractThe pathobiology of pulmonary arterial hypertension (PAH) includes endothelial cell dysfunction and proliferation and migration of VSMCs。 As PDGF has been implicated in these processes, Sc...

摘要：1Department of Internal Medicine and2IBM II: Molecular Cell Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany。 AbstractAPOA5 is a newly identified apolipoprotein that plays a crucia...

摘要：The primary implication of these findings is that the elevated expression of IAPs is not coincidental but actually participates in oncogenesis by helping to allow the malignant cell to avoid apopto...

摘要：AbstractThe amygdala is believed to play a key role in assigning emotional significance to specific sensory input, and conditions such as anxiety, autism, stress, and phobias are thought to be link...

摘要：AbstractCholesterol efflux from macrophages, the first step in reverse cholesterol transport (RCT), is assumed to play a critical role in the pathogenesis of atherosclerosis。 A surprisingly effici...

摘要：AbstractThis study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulati...

摘要：AbstractTransverse myelitis (TM) is an immune-mediated spinal cord disorder associated with inflammation, demyelination, and axonal damage。 We investigated the soluble immune derangements present ...

摘要：AbstractTNF receptor–associated factor 6 (TRAF6) associates with the cytoplasmic domain of receptor activator of NF-B (RANK)。 This event is central to normal osteoclastogenesis。 We discovered th...

摘要：AbstractThrombotic thrombocytopenic purpura (TTP) is a life-threatening illness caused by deficiency of the vWF-cleaving protease ADAMTS13。 Here we show that ADAMTS13-deficient mice are viable and...

摘要：AbstractWe investigated the role of cAMP-responsive element–binding protein (CREB) in genetic predisposition to anxiety and alcohol-drinking behaviors using alcohol-preferring (P) and -nonpreferri...

摘要：AbstractDeficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline。 Here we report that, in cytokine-stressed human neural cells, DHA atte...

摘要：AbstractProgression of pulmonary hypertension is associated with increased proliferation and migration of pulmonary vascular smooth muscle cells。 PDGF is a potent mitogen and involved in this proc...

摘要：AbstractX-linked recessive hypoparathyroidism, due to parathyroid agenesis, has been mapped to a 906-kb region on Xq27 that contains 3 genes (ATP11C, U7snRNA, and SOX3), and analyses have not revea...

摘要：We show that a missense mutation of MMP13 causes the Missouri type of human spondyloepimetaphyseal dysplasia (SEMDMO), an autosomal dominant disorder characterized by defective growth and modeling ...

摘要：AbstractDietary polyunsaturated fatty acids (PUFAs) are potent inhibitors of hepatic glycolysis and lipogenesis。 Recently, carbohydrate-responsive element–binding protein (ChREBP) was implicated ...

摘要：The present studies used model systems consisting of platelet-activating factor receptor–positive and –negative (PAF-R–positive and –negative) cells and PAF-R–deficient mice to demonstrate tha...

摘要：AbstractWhile type 1 hyperlipidemia is associated with lipoprotein lipase or apoCII deficiencies, the etiology of type 5 hyperlipidemia remains largely unknown。 We explored a new candidate gene, A...

摘要：AbstractNADH:ubiquinone oxidoreductase (complex I) deficiency is a common cause of mitochondrial oxidative phosphorylation disease。 In at least half of patients, enzyme deficiency results from a f...

摘要：AbstractDrusen are extracellular deposits that lie beneath the retinal pigment epithelium (RPE) and are the earliest signs of age-related macular degeneration (AMD)。 Recent proteome analysis demon...

摘要：AbstractDisruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been ...

摘要：AbstractHepatic expression of the scavenger receptor class B type I (SR-BI) promotes selective uptake of HDL cholesterol by the liver and is believed to play a role in the process of reverse choles...

摘要：In this study, we determined whether apoptosis influenced host resistance to the fungus Histoplasma capsulatum。 capsulatum infection。 capsulatum–infected gld/gld and TNF-–deficient mice。 capsu...

摘要：AbstractBeryllium exposure can lead to the development of beryllium-specific CD4+ T cells and chronic beryllium disease (CBD), which is characterized by the presence of lung granulomas and a CD4+ T...