摘要：The $3 billion California stem cell initiative has finally awarded its first set of grants。 The granting agency, the California Institute for Regenerative Medicine (CIRM), allocated a total of nea...

摘要：He is working hard to find temporary labs for his faculty, postdocs, and students and is also trying to persuade the LSU Health Science Center leadership to establish temporary labs in Baton Rouge ...

摘要：The obsession with medical advances and the high cost of false promisesAmerican Management Association。 New York, New York, USA。Reviewed by Simon ChapmanUniversity of Sydney, Sydney, New South Wa...

摘要：ukIn Evolution in four dimensions: genetic, epigenetic, behavioral, and symbolic variation in the history of life, Eva Jablonka and Marion J。 Waddington treated the pupae of fruit flies with heat ...

摘要：AbstractCytokines secreted by cells that mediate the innate and adaptive immune responses play a critical role in regulating the synthesis of ECM components by fibroblasts。 The contribution of CD4...

摘要：Louis, Missouri, USA。 In addition to its high caloric density, dietary fat has a hyperphagic effect, in part as a result of its high palatability。 of CD36 as a taste receptor for fatty acids prov...

摘要：See the related article beginning on page 3026Good things come in small packages, and for nearly a century the minuscule fruit fly Drosophila melanogaster has been generous to researchers, leading ...

摘要：AbstractClassically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can als...

摘要：AbstractDiscovery of mutated genes that cause various types of primary immunodeficiencies has significantly advanced our understanding of the pathogenesis of these diseases and of the functions of ...

摘要：The vasculature within tissues also responds to acute regional hypoxia by dilation of arterioles that control the flow of blood into each capillary bed, as in the case of increased O2 consumption i...

摘要：AbstractInflammatory angiogenesis is a critical process in tumor progression and other diseases。 The inflammatory cytokine IL-1。 promotes angiogenesis, tumor growth, and metastasis, but its mecha...

摘要：AbstractThe molecular and cellular pathways that support the maintenance and stability of tumor neovessels are not well defined。 The efficacy of microtubule-disrupting agents, such as combretastat...

摘要：AbstractHemin upregulates heme oxygenase-1 (HO-1), a stress-induced enzyme implicated in protection from a variety of injuries while its related isoform HO-2 is constitutively expressed。 The role ...

摘要：AbstractThe molecular anatomy of cancer cells is being explored through unbiased approaches aimed at the identification of cancer-specific transcriptional signatures。 Transcriptional signatures th...

摘要：AbstractHereditary spastic paraplegias (HSPs) are a group of neurodegenerative diseases characterized by progressive weakness and spasticity of the lower limbs。 Dominant mutations in the human SPG...

摘要：AbstractMany proinflammatory cytokines, such as leptin, play key roles in dynamic regulation of energy expenditure and food intake。 The present work tested a role for the proinflammatory cytokine ...

摘要：AbstractAng II type 1 (AT1) receptors activate both conventional heterotrimeric G protein–dependent and unconventional G protein–independent mechanisms。 We investigated how these different mecha...

摘要：AbstractThe Th1 and Th2 T cell responses that underlie inflammatory bowel diseases (IBDs) are likely to depend on NF-B transcriptional activity。 administration of decoy ODNs encapsulated in a vira...

摘要：AbstractAnalysis of mononuclear cells in the adult mouse liver revealed that B cells represent as much as half of the intrahepatic lymphocyte population。 VDJ gene rearrangements in IHB cells conta...

摘要：AbstractThe cytokines B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) enhance autoimmune disease by sustaining B cell activation。 We examined 72 tissues representing the...

摘要：AbstractNKT cells have pivotal roles in immune regulation and tumor immunosurveillance。 We report that the G-CSF and FMS-like tyrosine kinase 3 ligand (Flt-3L) chimeric cytokine, progenipoietin-1,...

摘要：AbstractThe hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i。, neurogenesis。 Most drugs of abuse examined...

摘要：AbstractPanton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by Staphylococcus aureus that has recently been associated with necrotizing pneumonia。 Furthermore, LukS-PV, 1 of the 2 c...

摘要：AbstractWe tested the hypothesis that induction of neuronal NO synthase (nNOS) impairs vascular smooth muscle contractility after hypoxia。 Ca2+-dependent NO synthase activity was increased in endo...

摘要：AbstractWe describe here a patient with a clinical and molecular diagnosis of recombinase activating gene 1–deficient (RAG1-deficient) SCID, who produced specific antibodies despite minimal B cell...

摘要：AbstractEpidemiologic evidence has established a relationship between microbial infection and atherosclerosis。 TLR2 has a large ligand repertoire that includes bacterial-derived exogenous and poss...

摘要：AbstractAutoantibodies against the epidermal desmosomal cadherins desmoglein 1 (Dsg1) and Dsg3 have been shown to cause severe to lethal skin blistering clinically defined as pemphigus foliaceus (P...

摘要：Notch signaling denotes cleavage of the Notch intracellular domain, its translocation to the nucleus, and subsequent activation of target gene transcription。 Involvement of Notch signaling in seve...

摘要：Such a behavior raises the possibility that an orosensory system is responsible for the detection of dietary lipids。 The fatty acid transporter CD36 appears to be a plausible candidate for this fu...

摘要：AbstractDecreased IL-2 production in systemic lupus erythematosus (SLE) represents a central component of the disease immunopathology。 We report that the message, protein, and enzymatic activity o...

摘要：AbstractBreach of B cell tolerance is central to the pathogenesis of systemic lupus erythematosus (SLE)。 However, how B cell tolerance is subverted in human SLE is poorly understood due to difficu...

摘要：AbstractThe G protein Gs is essential for hormone-stimulated cAMP generation and is an important metabolic regulator。 We investigated the role of liver Gs-signaling pathways by developing mice wit...

摘要：AbstractVascular SMC proliferation is a crucial event in occlusive cardiovascular diseases。 PPAR is a nuclear receptor controlling lipid metabolism and inflammation, but its role in the regulation...

摘要：AbstractThymic tissue has previously been considered a requirement for the generation of a functional and diverse population of human T cells。 We report that fibroblasts and keratinocytes from hum...

摘要：AbstractThe persistence of latently infected, resting CD4+ T cells is considered to be a major obstacle in preventing the eradication of HIV-1 even in patients who have received effective antiviral...

摘要：AbstractDC-specific ICAM3-grabbing non-integrin (DC-SIGN), which is expressed on DCs, can interact with a variety of pathogens such as HIV-1, hepatitis C, Ebola, cytomegalovirus, Dengue virus, Myco...