摘要：eduThe 20th century has often been associated with the advent of nuclear phenomena: the use of the atomic bomb to finally end World War II, the development of nuclear power for the generation of el...

摘要：orgAccording to Greg Critser’s new book, Generation Rx, in 1993, the average annual number of prescriptions per person in the US was seven。 Subtitled How prescription drugs are altering American ...

摘要：AbstractThe incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem。 While genetic factors contribute to susceptibility and...

摘要：show that the common polymorphism of the cardiac voltage-gated sodium channel, type V (SCN5A), designated S1103Y, found in African Americans is associated with an increased risk of sudden infant de...

摘要：AbstractUpper gastrointestinal dysfunction occurs frequently in diabetes and potentially contributes to both abdominal symptoms and impaired glycemic control。 conversely, variations in blood gluco...

摘要：AbstractPrevious studies suggest that insulin can inhibit hepatic glucose production (HGP) by both direct and indirect actions。 The indirect effects include inhibition of glucagon secretion, reduc...

摘要：Synergism between C3b and IgG and their receptors in promoting adherence to and then ingestion of an antigen has been recognized for decades。 Only more recently, however, has cross-talk between an...

摘要：AbstractMucous hypersecretion is a major cause of airway obstruction in asthma, chronic obstructive pulmonary disease, and cystic fibrosis。 show, in a mouse model of chronic mucous hypersecretion,...

摘要：Specifically, XLP patients do not generate a normal number of CD27+ memory B cells, and those few that are present are IgM+。 Recent studies have suggested that IgM+CD27+ B cells are not true memor...

摘要：2Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA。3Stroke and Neurovascular Regulation Laboratory, Massachusetts Gener...

摘要：AbstractDiabetes can result in loss of enteric neurons and subsequent gastrointestinal complications。 The mechanism of enteric neuronal loss in diabetes is not known。 We examined the effects of h...

摘要：AbstractEpithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic disease, but the basis for the altered epithelial phenotype is often uncertain。 Here we show that l...

摘要：AbstractIschemia/reperfusion (I/R) of several organs results in complement activation, but the kidney is unique in that activation after I/R occurs only via the alternative pathway。 We hypothesize...

摘要：AbstractIn response to hypoxia, hypoxia-inducible factors act as the primary proangiogenic triggers by regulating transcription levels of target genes, including VEGF。 We show that in the postnata...

摘要：AbstractProtein misfolding and aggregation are thought to underlie the pathogenesis of many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a stepwise protein misfolding process...

摘要：AbstractChoroideremia (CHM) is an X-linked degeneration of the retinal pigment epithelium (RPE), photoreceptors, and choroid, caused by loss of function of the CHM/REP1 gene。 Heterozygous-null fem...

摘要：In this study, we attempted to identify the genes associated with cataract formation in SCRs by positional cloning。 Hypomorphic mutations were identified in genes for lanosterol synthase (Lss) on ...

摘要：The data indicate that replacement of Cx43 by Cx32 is associated with decreased expression and secretion of renin, thus preventing the renin-dependent hypertension that is normally induced in the 2...

摘要：AbstractThe transcription factor T-bet (Tbx21) plays a major role in adaptive immunity and is required for optimal IFN- production by DCs。 Here we demonstrate an essential function for T-bet in DC...

摘要：AbstractVEGF-A promotes angiogenesis in many tissues。 Here we report that choroidal neovascularization (CNV) incited by injury was increased by excess VEGF-A before injury but was suppressed by VE...

摘要：While 2 cases have been associated with mutations in type V, cardiac voltage-gated sodium channels (SCN5A), the “Back to Sleep“ campaign has decreased SIDS prevalence, consistent with a role for ...

摘要：AbstractDevelopmental exposure to appropriate levels of thyroid hormones (THs) in a timely manner is critical to normal development in vertebrates。 From postnatal day 15 to adulthood, D3KO mice de...

摘要：AbstractTregs play a central role in the suppression of immune reactions and prevention of autoimmune responses harmful to the host。 During acute infection, however, Tregs might hinder effector T ...

摘要：AbstractNull mutations of the proopiomelanocortin gene (Pomc–/–) cause obesity in humans and rodents, but the contributions of central versus pituitary POMC deficiency are not fully established。...

摘要：AbstractGlyceryl trinitrate (GTN), also known as nitroglycerin, has been used to treat angina and heart failure for more than 130 years。 Recently, it was shown that mitochondrial aldehyde dehydrog...

摘要：AbstractMucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics。 Here we show that mucoid bacte...

摘要：IntroductionLeptin is a cytokine-like hormone that links nutritional status with the immune system (1, 2)。 Leptin regulates body weight through inhibition of food intake and stimulation of energy ...

摘要：AbstractInflammatory diseases of the CNS, such as MS and its animal model EAE, are characterized by infiltration of activated lymphocytes and phagocytes into the CNS。 TLRs recognize microbes and a...

摘要：AbstractCD8+ T cells play a key role in clearing primary virus infections and in protecting against subsequent challenge。 The potent antiviral effects of these cells make them important components...

摘要：Among signaling molecules downstream of RANK, 1,25(OH)2D3 inhibited the induction of c-Fos protein after RANKL stimulation, and retroviral expression of c-Fos protein abrogated the suppressive effe...

摘要：EE patients had a striking transcript signature involving 1% of the human genome that was remarkably conserved across sex, age, and allergic status and was distinct from that associated with non-EE...

摘要：AbstractInsulin inhibits glucose production through both direct and indirect effects on the liver。 however, considerable controversy exists regarding the relative importance of these effects。 The...

摘要：In contrast, up until now, no specific contribution of C5a and its receptor, C5aR, was recognized in diseases of antibody-dependent type II autoimmunity。 Here we identify C5a as a novel key mediat...

摘要：Tomohisa Nagoshi, Takashi Matsui, Takuma Aoyama, Annarosa Leri, Piero Anversa, Ling Li, Wataru Ogawa, Federica del Monte, Judith K。 Gwathmey, Luanda Grazette, Brian A。 Hemmings, David A。 Kass, H...

摘要：Original citation: J。 Clin。 Invest。 115:3428 –3439 (2005)。 doi:10。1172/JCI23587Citation for this corrigendum: J。 Clin。 Invest。 116:548 (2006)。 doi:10。1172/JCI23587C1In the original autho...

摘要：Original citation: J。 Clin。 Invest。 115:3451 –3459 (2005)。 doi:10。1172/JCI25461Citation for this corrigendum: J。 Clin。 Invest。 116:548 (2006)。 doi:10。1172/JCI25461C1Figure 6B was incorre...