摘要：Mancini)Introducing a popular science book to the masses that covers the depth and breadth of the green fluorescent protein (GFP) revolution is a large undertaking, but one that Marc Zimmer has tak...

摘要：eduI grew up believing that environmentalism was a common sense approach to life, grounded in epidemiology and basic science。 Over time, I have seen environmentalism, along with other areas where ...

摘要：AbstractEstrogen receptors, PPARs, and liver X receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors that regulate diverse aspects of development and h...

摘要：AbstractEstrogens influence many physiological processes in mammals, including but not limited to reproduction, cardiovascular health, bone integrity, cognition, and behavior。 Given this widesprea...

摘要：rosclérose, Institut Pasteur de Lille, INSERM U545, and Université de Lille 2, Lille, France AbstractPPAR is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as well a...

摘要：AbstractThe nuclear receptor family of PPARs was named for the ability of the original member to induce hepatic peroxisome proliferation in mice in response to xenobiotic stimuli。 However, studies...

摘要：AbstractObesity is a growing threat to global health by virtue of its association with insulin resistance, glucose intolerance, hypertension, and dyslipidemia, collectively known as the metabolic s...

摘要：The subsequent tissue response involves an intricate series of events including inflammation, oxidative stress, immune cell recruitment, and cell survival, proliferation, migration, and differentia...

摘要：AbstractThe liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism。 In addition to their function in lipid metabolism, LXRs have ...

摘要：AbstractMembers of the PPAR coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways。 ...

摘要：AbstractThe anaphylatoxins complement component 3a and 5a (C3a and C5a, respectively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce ed...

摘要：A group of highly conserved urothelial differentiation-related membrane proteins。

摘要：AbstractThe ghrelin receptor is known from in vitro studies to signal in the absence of the hormone ghrelin at almost 50% of its maximal capacity。 But, as for many other 7-transmembrane receptors,...

摘要：AbstractThe precise role of erythropoietin receptor–activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear。 In this issue of the JCI, Menon and colleagues present ne...

摘要：AbstractCD34+ bone marrow–derived progenitor cells contribute to tissue repair by differentiating into endothelial cells, vascular smooth muscle cells, hematopoietic cells, and possibly other cell...

摘要：The identification of mutations in the nuclear envelope proteins lamin A and lamin C as the cause of a diverse group of human diseases has expanded our understanding of the lamin proteins from bein...

摘要：AbstractCa2+ plays a pivotal role in both excitation-contraction coupling (ECC) and activation of Ca2+-dependent signaling pathways。 One of the remaining questions in cardiac biology is how Ca2+-d...

摘要：The gene encoding the T-box transcription factor Tbx18 was expressed in undifferentiated mesenchymal cells surrounding the distal ureter stalk。 In Tbx18–/– mice, prospective ureteral mesenchymal...

摘要：AbstractPrevious work showed that calmodulin (CaM) and Ca2+-CaM–dependent protein kinase II (CaMKII) are somehow involved in cardiac hypertrophic signaling, that inositol 1,4,5-trisphosphate recep...

摘要：AbstractAnemia due to chronic disease or chemotherapy often is ameliorated by erythropoietin (Epo)。 Present studies reveal that, unlike steady-state erythropoiesis, erythropoiesis during anemia de...

摘要：AbstractIn models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of polymorphonuclear leukocytes (PMNs) into the lung。 Since CXCR2 ligands, including CXCL1 and CXCL2/3, ...

摘要：AbstractIFN regulatory factor 4–binding (IRF-4–binding) protein (IBP) is a novel type of activator of Rho GTPases that is recruited to the immunological synapse upon TCR stimulation。 Here we dem...

摘要：AbstractAntagonists to 4 integrin show promise for several autoimmune and inflammatory diseases but may exhibit mechanism-based toxicities。 We generated and characterized mice bearing a Y991A muta...

摘要：The differences between selective and nonselective BAFF blockade are relevant to the choice of a BAFF blocking agent for the treatment of autoimmune and malignant diseases。 Some, such as BAFF-R–I...

摘要：AbstractKaposi sarcoma–associated herpesvirus (KSHV) is a human lymphotropic herpesvirus。 It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman diseas...

摘要：AbstractLamin A and lamin C, both products of Lmna, are key components of the nuclear lamina。 In the mouse, a deficiency in both lamin A and lamin C leads to slow growth, muscle weakness, and deat...

摘要：Fractionation of the bronchoalveolar lavage fluid demonstrated the presence of elastin fragments only in the fractions containing chemotactic activity。 An mAb against elastin fragments eliminated ...

摘要：1INSERM, U654, Centre Hospitalier Universitaire Henri-Mondor, Créteil, France。2Université Paris 12, Faculté de Médecine, Créteil, France。pital Armand-Trousseau, Service d’Explorations Fonct...

摘要：AbstractCD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs。 Its blockade has been shown to prevent allograft rejection, presumably b...

摘要：cell function and altered 。 cell mass。 cell mass and its adaptation to insulin resistance are unknown。 cell hyperplasia is achieved via proliferation of existing 。

摘要：Importantly, C5aR-deficient mice exhibited a similar, increased allergic phenotype。 These data suggest a dual role for C5a in allergic asthma, i。, protection from the development of maladaptive t...

摘要：AbstractThe cystic fibrosis transmembrane conductance regulator (CFTR) Cl– channel plays vital roles in fluid transport in many epithelia。 While CFTR is expressed along the entire nephron, its fu...

摘要：AbstractTransgenic sickle mice expressing 。S hemoglobin have activated vascular endothelium that exhibits enhanced expression of NF-B and adhesion molecules that promote vascular stasis in sickle,...

摘要：AbstractHepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads to hepatic insulin resistance。 We used a diet-induced rat model of nonalcoholic fatty liver dise...

摘要：AbstractDisruption of cholinergic neurotransmission contributes to the memory impairment that characterizes Alzheimer disease (AD)。 Treatment of PDAPP mice with the anti-A。 Treatment with certain...