摘要：Are we ready for the next plague。 Zelicoff , Michael Bellomo and Microbe Are we ready for the next plague。net As indicated by the authors, Microbe is intended for a lay audience, ostensibly a sop...

摘要：How money, science, and politics drive the commerce of conceptionDebora L。 Spar and The baby business How money, science, and politics drive the commerce of conception 2006 Harvard Business School...

摘要：Abstract As representatives of 50 leading academic medical centers focusing on clinical research and many of academic medicine’s scientific leaders, the Clinical Research Forum and Association of ...

摘要：AbstractGout is an autoinflammatory disorder associated with deposition of monosodium urate (MSU) crystals in joints and periarticular tissues。Gout is considered one of the most painful acute cond...

摘要：AbstractIn this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related...

摘要：AbstractAIDS is characterized by CD4+ T lymphocyte depletion, yet the mechanisms underlying this central aspect of HIV pathogenesis are still poorly understood。 identify a mechanism by which the H...

摘要：Targeting these pathways harnesses the physiologic mechanisms of regulating autoimmunity and could prove beneficial for the therapy of autoimmune diseases。 describe a creative approach for targeti...

摘要：In this issue of the JCI, 2 studies of very different mouse models of psoriasis both report that macrophages play a key role in inducing psoriasis-like skin disease。 The debate that currently rage...

摘要：A study by Wang and colleagues in this issue of the JCI demonstrates that a critical balance between anandamide synthesis by N-acylphosphatidylethanolamine–selective phospholipase D (NAPE-PLD) and...

摘要：AbstractThe glomerular capillaries function as the filtration barrier that retains albumin and other plasma proteins in the circulation。 There is considerable evidence implicating both the glomeru...

摘要：AbstractPsoriasis is a common skin disease, the pathogenesis of which has not yet been resolved。 In mice, epidermis-specific deletion of inhibitor of NF-B (IB) kinase 2 (IKK2) results in a skin ph...

摘要：Previously we found that this chronic psoriasiform skin inflammation also depends on the presence of CD4+ T cells。 Herein we investigated the role of macrophages in this CD18hypo mouse model。 Act...

摘要：AbstractThe epidemic scourge of rickets in the 19th century was caused by vitamin D deficiency due to inadequate sun exposure and resulted in growth retardation, muscle weakness, skeletal deformiti...

摘要：AbstractHutchinson-Gilford progeria syndrome (HGPS) is caused by the production of a truncated prelamin A, called progerin, which is farnesylated at its carboxyl terminus。 To determine whether an ...

摘要：Cannabinoid/endocannabinoid signaling via cannabinoid receptor CB1 is known to influence early pregnancy。 Here we provide evidence that a critical balance between anandamide synthesis by N-acylpho...

摘要：AbstractTumor-associated macrophages (TAMs) are associated with tumor progression and metastasis。 In fact, a legumain-based DNA vaccine served as a tool to prove this point, as it induced a robust...

摘要：AbstractThe pathogenesis of glucocorticoid-induced (GC-induced) bone loss is unclear。 For example, osteoblast apoptosis is enhanced by GCs in vivo, but they stimulate bone formation in vitro。 Thi...

摘要：AbstractHIV-1 envelope glycoproteins (Env), expressed at the cell surface, induce apoptosis of uninfected CD4+ T cells, contributing to the development of AIDS。 Here we demonstrate that, independe...

摘要：AbstractThe neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers。 Selective expres...

摘要：AbstractAdenosine has been implicated in the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary disease。 In vitro studies suggest that activation of the A2B ade...

摘要：AbstractThe adipocyte fatty acid–binding protein aP2 regulates systemic glucose and lipid metabolism。 We report that aP2, in addition to being abundantly expressed by adipocytes, is also expresse...

摘要：AbstractEpidermal nevi are common congenital skin lesions with an incidence of 1 in 1,000 people。 Germline mutations of the FGF receptor 3 (FGFR3) cause autosomal dominant skeletal disorders such ...

摘要：AbstractThe carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE)。 To clarify the physiological roles of ACE2, we generated mice with targeted disruption of the Ace2 gene。 A...

摘要：AbstractCeliac disease is associated with HLA-DQ2 and, to a lesser extent, HLA-DQ8。 T cells that are reactive with gluten peptides deamidated by transglutaminase 2 and invariably restricted by DQ2...

摘要：Although vaginal application of CpG oligodeoxynucleotides (ODNs) and poly I:C has been shown to protect mice from genital herpes infection, the mechanism by which these agents provide protection re...

摘要：AbstractAnaphylactic shock is a sudden, life-threatening allergic reaction associated with severe hypotension。 Platelet-activating factor (PAF) is implicated in the cardiovascular dysfunctions occ...

摘要：AbstractCTL-associated antigen 4 (CTLA-4) engagement negatively regulates T cell activation and function and promotes immune tolerance。 However, it has been difficult to explore the biology of sel...

摘要：Here we find that the Toll/IL-1R (TIR) signal transduction adaptor myeloid differentiation primary response protein 88 (MyD88) is required for acute gouty inflammation。 The MyD88-dependent TLR1, -...

摘要：AbstractPrimary defects in either podocytes or the glomerular basement membrane (GBM) cause proteinuria, a fact that complicates defining the barrier to albumin。2 (LAMB2) is a GBM component requir...

摘要：AbstractWhile it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in xenobiotic metabolism and that exposure to xenobiotic chemi...

摘要：AbstractNeurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases。 Modified antisense oligonucleotides, continuously infused intra...

摘要：Original citation: J。 Clin。 Invest。 116:80-89 (2006)。 doi:10。1172/JCI25716 Citation for this erratum: J。 Clin。 Invest。 116:2306-2307 (2006)。 doi:10。1172/JCI25716E1 During the preparation ...

摘要：Clin。 Clin。