摘要：in this issue of the JCI shows that in humans, Tregs are present throughout life but that despite their high throughput, they are short lived (see the related article beginning on page 2423)。The e...

摘要：It has been debated whether the malformations result from low cholesterol or the buildup of sterol precursors。 provide evidence that sterol precursor accumulation plays a pivotal role in the genes...

摘要：Activated cells then secrete IFN- and TNF-, which trigger tissue release of chemokines that attract self-reactive CD8+ T cells, ultimately leading to liver damage。 In a mouse model of hepatitis, l...

摘要：Their findings raise the intriguing possibility that the promotion of endothelial regeneration may be a novel therapeutic strategy for ALI。 Pathophysiology of acute lung injuryAcute lung injury (A...

摘要：Figure 1A mighty mouse for MS research。 The mouse model was descriptively termed OSE by Krishnamoorthy et al。 Third, cytokine production in OSE mice resembled that seen in active immunization–in...

摘要：Straus, and Alex Straus and Medical marvelsThe 100 greatest advances in medicine 2006 Prometheus Books。00 Weill Medical College of Cornell University and Veterans Affairs Medical Center, New York,...

摘要：Podolsky and Pneumonia before antibioticsTherapeutic evolution and evaluation in twentieth-century America 2006 The Johns Hopkins University Press。 Weiser) Streptococcus pneumoniae (the pneumococc...

摘要：AbstractRecently, MIT professor and Nobel laureate Susumu Tonegawa has come under attack for allegedly opposing the recruitment of a female, prospective junior faculty member to MIT because her wor...

摘要：In 2002, the synthetic ligand estren was described to reproduce the bone anabolic, nongenotropic effects of sex steroids while having no effect on the uterus or seminal vesicles。 provide data show...

摘要：AbstractIn this issue of the JCI, Stasch and colleagues suggest that a novel drug, BAY 58-2667, potently activates a pool of oxidized and heme-free soluble guanylyl cyclase (sGC。 The increased vas...

摘要：AbstractRecovery of endothelial integrity after vascular injury is vital for endothelial barrier function and vascular homeostasis。 However, little is known about the molecular mechanisms of endot...

摘要：AbstractBmx/Etk non-receptor tyrosine protein kinase has been implicated in endothelial cell migration and tube formation in vitro。 However, the role of Bmx in vivo is not known。 Bmx is highly in...

摘要：5 days of development, 96% of Insig-DKO embryos had defects in midline facial development, ranging from cleft palate (52%) to complete cleft face (44%)。 The livers and heads of Insig-DKO embryos o...

摘要：AbstractMany intracellular pathogens, including Toxoplasma gondii, survive within macrophages by residing in vacuoles that avoid fusion with lysosomes。 It is important to determine whether cell-me...

摘要：AbstractWe describe a double-transgenic mouse strain (opticospinal EAE mouse) that spontaneously develops an EAE-like neurological syndrome closely resembling a human variant of multiple scle...

摘要：also known as von Recklinghausen’s disease) is a common autosomal-dominant condition primarily affecting neural crest–derived tissues。 The disease gene, NF1, encodes neurofibromin, a protein of ...

摘要：AbstractMultiple sclerosis (MS) is a clinically and pathologically heterogeneous inflammatory/demyelinating disease of the CNS。 In the MS variant Devic disease, lesions are predominantly found in ...

摘要：AbstractAng II receptor activation increases cytosolic Ca2+ levels to enhance the synthesis and secretion of aldosterone, a recently identified early pathogenic stimulus that adversely influences c...

摘要：3Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, New York, USA。 AbstractThe role of cardiocytes in physiologic removal of apoptotic cells and the subsequent effe...

摘要：AbstractIFN- is an important Th1 proinflammatory cytokine and has a paradoxical effect on EAE in which disease susceptibility is unexpectedly heightened in IFN-–deficient mice。 In this study, we ...

摘要：AbstractThe transcription factor SOX2 is expressed most notably in the developing CNS and placodes, where it plays critical roles in embryogenesis。 Heterozygous de novo mutations in SOX2 have prev...

摘要：AbstractThe liver is known to be a classical immunoprivileged site with a relatively high resistance against immune responses。 Here we demonstrate that highly activated liver-specific effector CD8...

摘要：AbstractHepatic insulin resistance affects both carbohydrate and lipid metabolism。 It has been proposed that insulin controls these 2 metabolic branches through distinct signaling pathways。 Here ...

摘要：AbstractThe forkhead transcription factor FoxO1 has been identified as a negative regulator of insulin/IGF-1 signaling。 However, the structure/function relationship of FoxO1 has not been elucidate...

摘要：AbstractNKT cells promote antibody-induced arthritis, but the mechanism by which NKT cells are activated in this model remains unclear。 It has been proposed that Fc receptor (FcR) contributes to N...

摘要：AbstractTNF-related apoptosis–inducing ligand (TRAIL) is a member of the TNF family with potent apoptosis-inducing properties in tumor cells。 In particular, TRAIL strongly synergizes with convent...

摘要：AbstractThe use of estrogens and androgens to prevent bone loss is limited by their unwanted side effects, especially in reproductive organs and breast。 Selective estrogen receptor modulators (SER...

摘要：AbstractCardiac calsequestrin (Casq2) is thought to be the key sarcoplasmic reticulum (SR) Ca2+ storage protein essential for SR Ca2+ release in mammalian heart。 Human CASQ2 mutations are associat...

摘要：AbstractOne of the greatest barriers against harnessing the potential of CD4+CD25+ Tregs as a cellular immunotherapy is their hypoproliferative phenotype。 We have previously shown that the hypopro...

摘要：AbstractSepsis results in a state of relative immunosuppression, rendering critically ill patients susceptible to secondary infections and increased mortality。 We investigated the role of the LPS/...

摘要：AbstractOne approach to enhancing the T cell response to tumors is vaccination with mimotopes, mimics of tumor epitopes。 While mimotopes can stimulate proliferation of T cells that recognize tumor...

摘要：Increased oxidative stress affects the heme-containing NO receptor sGC by both decreasing its expression levels and impairing NO-induced activation, making vasodilator therapy with NO donors less e...

摘要：Original citation: J。 Clin。 Invest。 116:2193-2200 (2006)。 doi:10。1172/JCI26605。 Citation for this corrigendum: J。 Clin。 Invest。 116:2562 (2006)。 doi:10。1172/JCI26605C1。 One of the grant...