摘要：Osteomalacia is a frequent complication resulting from long-term therapy with drugs such as phenytoin, carbamazepine, and phenobarbital。 We have investigated the crosstalk between pregnane X recep...

摘要：Keith Wailoo, and Stephen Pemberton, The troubled dream of genetic medicineEthnicity and innovation in Tay-Sachs, cystic fibrosis, and sickle cell disease 2006 The Johns Hopkins University Press。 ...

摘要：Dickerson and Yellow feverA deadly disease poised to kill again 2006 Prometheus Books。 Yellow fever has played a central role in the history of infectious diseases。 It was the first disease to be...

摘要：AbstractTriggered by an encounter with survivors of the studies on twins conducted in Auschwitz by Joseph Mengele, who held both MD and PhD degrees, I offer thoughts on the extraordinary powers phy...

摘要：AbstractThe deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient anima...

摘要：Since active anion secretion is not stimulated (in fact it is inhibited), a non–epithelial cell–mediated driving force must be present — most likely an increase in interstitial pressure due to a...

摘要：Current management of enterococcal endocarditis involves administration of a combination of antimicrobials。 Thus, research that has the potential to unveil new therapies or preventive measures tha...

摘要：AbstractSince the discovery of vascular-specific growth factors with angiogenic activity, there has been a significant effort to develop cancer drugs that restrict tumorigenesis by targeting the bl...

摘要：AbstractInflammation resultant from tumor growth, infection with certain pathogens, or in some cases, trauma, can result in systemic release of cytokines, especially GM-CSF, that in turn stimulate ...

摘要：The B7 family members are involved at several stages in this process。 show that the B7 family–related protein V-set and Ig domain–containing 4 (VSIG4) can act as an inhibitor of T cell activatio...

摘要：1Division of Experimental Hematology, Cincinnati Children’s Research Foundation and Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA。 show that postnatal HSCs as well as feta...

摘要：AbstractPulmonary surfactant proteins and lipids are required for lung function after birth。 To identify mechanisms controlling perinatal lung maturation, the Calcineurin b1 (Cnb1) gene was delete...

摘要：AbstractInhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment ends。 In the present study, r...

摘要：AbstractEctopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to development of lymphoid structures that resemble those observed in Hashimoto thyroiditis。 Deletion of the inhib...

摘要：AbstractTyrosine kinases play a central role in the activation of signal transduction pathways and cellular responses that mediate the pathogenesis of rheumatoid arthritis。 Imatinib mesylate (imat...

摘要：The architecture of the mammary fat pad allowed for detailed analysis of the cells’ interactions with resident murine blood vessels, which revealed specific induction of apoptosis in the endotheli...

摘要：AbstractAdrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life。 Plasma AM expression dramatically increases during pregnancy, and alterations in its levels are ass...

摘要：AbstractKennedy disease, a degenerative disorder characterized by androgen-dependent neuromuscular weakness, is caused by a CAG/glutamine tract expansion in the androgen receptor (Ar) gene。 We dev...

摘要：AbstractHigh levels of microphthalmia transcription factor (MITF) expression have been described in several cell types, including melanocytes, mast cells, and osteoclasts。 MITF plays a pivotal rol...

摘要：Abstract Acute T cell–mediated diarrhea is associated with increased mucosal expression of proinflammatory cytokines, including the TNF superfamily members TNF and LIGHT。 While we have previously...

摘要：AbstractEGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib。 A secondary mutation, T790M, has been associated with acquired resist...

摘要：AbstractWe previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting of an in-frame partial tandem duplication (PTD) of exons 5 th...

摘要：AbstractDefects in purine nucleoside phosphorylase (PNP) enzyme activity result in abnormal nucleoside homeostasis, severe T cell immunodeficiency, neurological dysfunction, and early death。 TAT i...

摘要：AbstractTight regulation of COX-2 expression is a key feature controlling eicosanoid production in atherosclerosis and other inflammatory syndromes。 Adhesive interactions between platelets and mon...

摘要：AbstractIn this study we investigated why bloodstream forms of Trypanosoma brucei gambiense cross human brain microvascular endothelial cells (BMECs), a human blood-brain barrier (BBB) model system...

摘要：AbstractMast cells are involved in many disorders where the triggering mechanism that leads to degranulation and/or cytokine secretion has not been defined。 Several chronic inflammatory diseases a...

摘要：AbstractTransgenic mice overexpressing PKC in the epidermis (K5-PKC mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic neutrophilia when PKC is activated by top...

摘要：Abstract Scavenger receptor SR-BI has been implicated in HDL-dependent atheroprotective mechanisms。 We report the generation of an SR-BI conditional knockout mouse model in which SR-BI gene target...

摘要：While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their i...

摘要：Thus, at metabolically relevant sites, including adipose tissue and muscle, there is abnormal production of proinflammatory cytokines such as TNF-。 Here we demonstrate that eNOS expression was red...

摘要：AbstractIncreasing multidrug resistance in Enterococcus faecalis, a nosocomial opportunist and common cause of bacterial endocarditis, emphasizes the need for alternative therapeutic approaches suc...

摘要：Here we show that in mice, all HSCs are cycling until 3 weeks after birth。 The defective engrafting activity of HSCs in S/G2/M was reversed when cells were allowed to progress into G1 prior to inj...

摘要：AbstractT cell activation by APCs is positively and negatively regulated by members of the B7 family。 We have identified a previously unknown function for B7 family–related protein V-set and Ig d...

摘要：The fluorescent image in Figure 3 that depicts TUNEL assay in vinblastine-treated tumors was incorrect。 The vinblastine fluorescence panel has therefore been eliminated in the corrected figure bel...

摘要：Melov), the Alzheimer‘s Association (to L。

摘要：Original Citation: J。 Clin。 Invest。 115:2297–2305 (2006)。 doi:10。1172/JCI27920。 Citation for this corrigendum: J。 Clin。 Invest。 116:2828 (2006)。 doi:10。1172/JCI27920C1。 In the original...

摘要：Original Citation: J。 Clin。 Invest。 115:2423–2433 (2006)。 doi:10。1172/JCI28941。 Citation for this corrigendum: J。 Clin。 Invest。 116:2828 (2006)。 doi:10。1172/JCI28941C1。 During the prep...